Results 111 to 120 of about 1,881,139 (280)
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
On left ideals of prime rings with generalized derivations
, 2005 In this paper the author considers a prime ring R with characteristic different from two and extends some well known results concerning derivations of prime rings to the generalized derivation f : R —> R associated with a derivation d of R ...
Öznur Gölbaşı
core +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
, 2013 Locations of electrodes involved in the studied derivations (left) with 30 seconds of EEG recorded in +/−100 µV panes (right). Top: top view of the head (nose pointing downwards) with Cz-Oz, Fz-Cz and Fpz-Cz EEG derivations.
Marco Roessen (442067) +3 more
core +1 more source
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source
Generalized derivations of left faithful rings
Communications in Algebra, 1999 Let R be a left faithful ringU its right Utumi quotient ring and ρ a dense right ideal of R. An additive map g: ρ → U is called a generalized derivation if there exists a derivation δ of ρ into U such that for all x,y∈ρ. In this note, we prove that there exists an element a∈ U such that for all x ∈ ρ.
openaire +2 more sources
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Jordan and left derivations on locally $C{*}$-algebras
, 2002 We show that left derivations as well as Jordan derivations on locally $C^{*}$-algebras are always continuous. We also obtain some noncommutative extensions of the classical Singer-Wermer theorem for locally $C^{*}$-algebras: (1) Every left derivation $D$
Shahzad, N
core
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source