Results 41 to 50 of about 2,394,289 (288)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Non-traumatic testicular dislocation mimicking incarcerated inguinal hernia in a one-year-old boy

Journal of Pediatric Surgery Case Reports, 2018
Testicular dislocation usually results from trauma to the scrotum or abdominoperineal area. We herein report a case of non-traumatic testicular dislocation in a one-year-old male patient.
Naruki Higashidate, Suguru Fukahori, Shinji Ishii, Nobuyuki Saikusa, Naoki Hashizume, Yoshinori Koga, Daisuke Masui, Shiori Tsuruhisa, Takato Aikoh, Shoutarou Taki, Yoshiaki Tanaka, Minoru Yagi   +11 more
doaj   +1 more source

Dorsal Approach in the Surgical Treatment of Complex Dorsal Dislocation of Index Metacarpophalangeal Joint; a Case Report

Archives of Academic Emergency Medicine, 2022
Complex metacarpophalangeal (MCP) joint dislocation is an uncommon entity, which occurs following a hyperextension injury. Closed reduction is not feasible due to entrapped volar plate and/or coexisting fractures.
Shahab Aldin Sattari, Ali Reza Sattari, Kamran Heydari, Seyed Matin Sadat Kiaei, Farshad Zandrahimi, Mehdi Mohammadpour   +5 more
doaj   +1 more source

The acquisition of clitic objects in Modern Greek : single clitics, clitic doubling, clitic left dislocation [PDF]

, 2013
The present study is concerned with Single Clitics, as weil as with Clitic Doubling and Clitic Left Dislocation constructions and will test the Uniformity Hypothesis (Sportiehe 1992), according to which all three constructions involve the same underlying
Marinis, Theodore
core  

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

L‐aspartate oxidase provides new insights into fumarate reduction in anaerobic darkness in Synechocystis sp. PCC6803

FEBS Letters, EarlyView.
Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil, Jeffrey A. Hawkes, Cecilia Blikstad, Pia Lindberg   +3 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

A functional profile of Left Dislocation in Biblical Hebrew

Stellenbosch Papers in Linguistics Plus, 2016
The primary aim of this paper is to provide a functional profile of verbal Left Dislocation (=LD) constructions in the Torah and Former Prophets (Genesis–2Kings). As a precursor, however, an abbreviated syntactico-semantic description of LD constructions
Westbury, Josh
doaj   +1 more source

Traumatic Lens Dislocation in an Eye with Anterior Megalophthalmos

Case Reports in Ophthalmological Medicine, 2022
Anterior megalophthalmos is a rare, bilateral, nonprogressive, hereditary, congenital disorder characterized by the enlargement of all anterior segment structures of the eye, with megalocornea, iris atrophy, and zonular abnormalities. We report a case of
Huda AlGhadeer
doaj   +1 more source