Results 61 to 70 of about 2,526,322 (292)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

A schematic of the experimental stimulus and example procedure when one point to the observer’s left hand side is cued (A), and the stimulus locations presented in the “mid-periphery” 12.7° (inner ring) and “periphery” 29.7° (outer ring) conditions.

, 2016
A schematic of the experimental stimulus and example procedure when one point to the observer’s left hand side is cued (A), and the stimulus locations presented in the “mid-periphery” 12.7° (inner ring) and “periphery” 29.7° (outer ring) conditions.
Sieu K. Khuu (413138), Michael Kalloniatis (388985), Jack Phu (2552731)   +2 more
core   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Mismatches and Mitigation at CS-PF Interface: The Curious Case of li

Languages
Taking the domain of polar questions in Bosnian/Croatian/Montenegrin/Serbian (BCMS) as the empirical background, the paper probes into the syntax–phonology (CS-PF) interface and discusses insertion and movement as PF-repair strategies mitigating against ...
Marijana Marelj
doaj   +1 more source

The Spec-head vs head-Spec asymmetry: Toward a theory of postsyntactic linearization and an account of the embeddedtopicalization paradox

Stellenbosch Papers in Linguistics, 2014
This paper is a preliminary exploration of how English specifiers and heads are linearized at the PF interface. In particular, it argues that linearization may reflect underlying grammatical relationships of agreement and selection.
de Vos, Mark
doaj   +1 more source

Haploidentical Hematopoietic Cell Transplantation for Infants With X‐Linked Severe Combined Immunodeficiency Using Post‐Transplant Cyclophosphamide

Pediatric Blood &Cancer, EarlyView.
Shuhei Takahashi, Akito Kawachi, Dan Tomomasa, Eri Watanabe, Yuji Fujita, Yuya Sato, Masahiro Sekiguchi, Kentaro Watanabe, Moe Hidaka, Akihiro Hoshino, Takahiro Kamiya, Masatoshi Takagi, Hirokazu Kanegane, Motohiro Kato   +13 more
wiley   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

Morphosyntactic Marking of Focus: Subject–Object Asymmetries in Bantu

Languages
In many African languages, there exists a type of subject–object asymmetry by which subject focus must be expressed by A-bar movement to a morphologically marked left peripheral position whereas object focalisation can be expressed by movement and ...
Paul Roger Bassong, Edmond Ossoko, Luigi Rizzi   +2 more
doaj   +1 more source

The Noun Phrase: Diversity in Dutch DP Design (DiDDD)

Nordlyd: Tromsø University Working Papers on Language & Linguistics, 2007
In this paper we discuss our project: Diversity in Dutch DP Design. This project investigates the variation found in the Dutch DP. Not only the variation concerning contemporary dialects is taken into account, also the variation between contemorary Dutch
Marjo van Koppen, Norbert Corver, Huib Kranendonk, Mirjam Rigterink   +3 more
doaj   +1 more source

Experimental testing of the left periphery

Linguistic Proceedings Series, 2020
This manuscript presents an empirical description of the left periphery based on the performance of speakers of Castilian Spanish in a corpus analysis, an acceptability judgment task, and a scripted production task. The picture drawn by the three studies look as follows: First, clitic-doubled left dislocations (CLLD) fulfil multiple discourse functions,
openaire   +1 more source