Results 71 to 80 of about 2,526,322 (292)

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

open access: yesFEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise   +5 more
wiley   +1 more source

Les questions en grammaire générative

open access: yesCorela, 2019
In this chapter, we address the generative approach to interrogative structures, mostly under the Principles & Parameters framework. After a brief theoretical overview, we discuss direct open and closed questions, then embedded questions, showing how I ...
Jean-Charles KHALIFA
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

open access: yesFEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward   +2 more
wiley   +1 more source

Smaller is better: nanobodies meet NMR

open access: yesFEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

Clitics and the Left Periphery in Cayuga

open access: yesStudies in Generative Grammar, 2014
We propose that pronominal markers in Cayuga are clitics that obey an updated version of the Tobler-Mussafia Law. Specifically, pronominal markers cannot appear at the left edge of an Intonational Phrase and undergo prosodic inversion at PF if they appear in that position at Spell-Out. This analysis has two important implications.
null Barrie Michael Jonathan Mathew   +2 more
openaire   +1 more source

Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis

open access: yesFEBS Letters, EarlyView.
This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng   +8 more
wiley   +1 more source

On a-Marking Topics in the Italian Left Periphery

open access: yes, 2018
In Italian Clitic Left Dislocated/ClLD structures in which the left dislocated topic is the direct object of the following clause, such object noun phrase may sometimes be introduced by preposition a.
Adriana Belletti
core   +1 more source

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

open access: yesFEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

Demystifying “Stylistic Fronting” in Medieval French

open access: yesIsogloss
This study re-examines the phenomenon traditionally termed Stylistic Fronting (SF) in Medieval French. Drawing on data from verse texts dating from the thirteenth to the fourteenth centuries, it investigates the syntactic distributions and pragmatic ...
Dong Hyun Kang
doaj   +1 more source

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