Results 101 to 110 of about 1,977,355 (211)
Experimental Realism Defended: How Inference to the Most Likely Cause Might Be Sound [PDF]
, 2005 On a purely epistemic understanding of experimental realism, manipulation affords a particularly robust kind of causal warrant, which is – like any other warrant – defeasible.
Suárez, Mauricio, Mauricio Suárez
core
Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein
FEBS Letters, EarlyView.Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux +7 more
wiley +1 more source
Why the Ultimate Argument for Scientific Realism Ultimately Fails [PDF]
, 2011 In this paper, I argue that the ultimate argument for Scientific Realism, also known as the No-Miracles Argument (NMA), ultimately fails as an abductive defence of Epistemic Scientific Realism (ESR), where (ESR) is the thesis that successful theories of ...
Mizrahi, Moti
core
Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research
FEBS Letters, EarlyView.What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley +1 more source
The Nouveau Roman and Cinema: The Problem of Representation
Cultural IntertextsThis paper reexamines the potential of the film medium to depict what cannot be seen or represented by established visual and narrative conventions by analysing the relationship between the French Nouveau Roman and the emergence of innovative cinematic ...
Višnja PENTIĆ
doaj +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Structural Realism and Abductive-Transcendental Arguments [PDF]
, 2007 The paper deals with an attempt to present an “abductive-transcendental” argument in favour of a particular version of structural realism (SR), dubbed Intermediate SR.
Lyre, Holger
core
Examining the Causes of Russian Presence in the Middle East after the uprisings (with an emphasis on Syria) [PDF]
سپهر سیاست, 2017 The Wave of popular uprisings in the Arabic countries in the Middle East led to overthrow of governments in Tunisia, Egypt, Libya and Yemen from one side and providing civil war in Syria from another side.
Davood Kiani
doaj
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source