Results 71 to 80 of about 1,977,355 (211)
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
The New Left. 1968 and Post Scriptum
Revista Mexicana de Ciencias Políticas y Sociales, 2018 INTRODUCTORY NOTE The author, a well know theorist and activist of the civil rights movement and the movement against the Vietnam War, published the first part of this article from his own intervention and experience in 1968.
Michael Walzer
doaj +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Three Metaphors toward a Conception of Moral Change
Nordic Wittgenstein Review, 2018 Contemporary moral philosophy is split between an inherently a-historical moral philosophy/theory on the one hand and a growing interest in moral history and the historicity of morality on the other.
Nora Hämäläinen
doaj +1 more source
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Structural realism and the mind [PDF]
, 2006 This paper considers whether, and how, the mind can be incorporated into structural realism. Section 1 begins with some definitions, and briefly reviews the main problems which beset structural realism.
McCabe, Gordon
core
Contexto Internacional, 2003 Uma dificuldade crucial no estudo das relações internacionais é unir investigação teórica com investigação histórica. O objetivo deste artigo é analisar como Hobbes enfrentou este problema, bem como em que medida a solução que apresentou influenciou a ...
Soraya Nour, Claus Zittel
doaj +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Left Realism, community and state-building [PDF]
, 2010 Left Realism, as it emerged in the mid 1980s in the UK was a policy-oriented intervention focusing on the reality of crime for the working class victim and the need to elaborate a socialist alternative to conservative emphases on ‘law and order’.
John Lea, Lea, John
core +1 more source