Results 141 to 150 of about 520,580 (355)

Inhibition of Phosphodiesterase 10A by MP‐10 Rescues Behavioral Deficits and Normalizes Microglial Morphology and Synaptic Pruning in A Mouse Model of FOXP1 Syndrome

Advanced Science, EarlyView.
We demonstrate that Foxp1± mice, modeling FOXP1 haploinsufficiency, exhibit behavioral deficits, striatal neuroinflammatory changes including altered microglial complexity and synaptic pruning, and markedly reduced Pde10a expression. Pde10a inhibition starting immediately after birth restores Foxp1± behavior, microglial morphology, and pruning ...
Henning Fröhlich, Jing Wang, Ferdinand Althammer, Tim Schubert, Nina Kluck, Valery Grinevich, Stefanie Schmitteckert, Christian P. Schaaf, Gudrun A. Rappold   +8 more
wiley   +1 more source

Biventricular Myocardial Noncompaction [PDF]

, 2006
The isolated noncompacted ventricular myocardium (NCVM), characterized by excessively prominent trabecular meshwork and deep intertrabecular recesses, is seen in the early period of embryogenesis.
Nizamettin Toprak, Onder Ozturk, Unal Ozturk   +2 more
core  

Echocardiographic assessment of left ventricular function in aortic valve disease. [PDF]

, 1976
Ian G. McDonald
openalex   +1 more source

Left ventricular function and hyperthyroidism. [PDF]

Heart, 1981
J. Chastre, P Passa, René Gourgon, A Wolf, J P Merillon   +4 more
openaire   +3 more sources

PFKM‐Driven Lactate Overproduction Promotes Atrial Fibrillation via Triggering Cardiac Fibroblasts Histone Lactylation

Advanced Science, EarlyView.
The upregulation of PFKM activates glycolysis, thereby enhancing lactate production in atrial tissue. Atrial lactate accumulation promotes global lactylation and H3K18 lactylation in atrial fibroblasts. P300‐mediated H3K18 lactylation up‐regulates TGF‐β1 transcription, leading to fibroblast activation and thereby contributing to atrial fibrosis.
Ning Fang, Ning Zhang, Xiaohui Jiang, Sen Yan, Zhiqi Wang, Qianhui Gao, Mingcheng Xu, Lin Mu, Xiaoming Li, Jiuling Chen, Song Zhang, Yu Duan, Fengxiang Yun, Luyifei Li, Yun Zhang, Yongtai Gong   +15 more
wiley   +1 more source

Adding ROS Scavengers to Cold K\u3csup\u3e+\u3c/sup\u3e Cardioplegia Reduces Superoxide Emission During 2 h Global Cold Cardiac Ischemia [PDF]

, 2012
We reported that the combination of reactive oxygen species (ROS) quenchers Mn(III) tetrakis (4-benzoic acid) porphyrin (MnTBAP), catalase, and glutathione (MCG) given before 2 hours cold ischemia better protected cardiac mitochondria against cold ...
Aldakkak, Mohammed, Camara, Amadou K.S., Heisner, James S., Riess, Matthias L., Stowe, David F.   +4 more
core   +1 more source

Left ventricular function following coronary bypass surgery. [PDF]

, 1978
N M Wolf, Thomas H. Kreulen, A. A. Bove, M T McDonough, K M Kessler, Michael D. Strong, Gerald M. Lemole, James F. Spann   +7 more
openalex   +1 more source

Gut Metabolite Indole‐3‐Propionic Acid Regulates Macrophage Autophagy Through PPT1 Inhibiting Aging‐Related Myocardial Fibrosis

Advanced Science, EarlyView.
IPA is an intestinal tryptophan metabolite whose effects decline with decreased heart function. Supplementing IPA can alleviate the aging‐related myocardial fibrosis through PPT1. PPT1 is a key protein localized to lysosomes, and IPA can restore macrophage autophagy function by regulating PPT1 expresssions, thereby reducing aging‐related myocardial ...
Jing Lu, Hongyan Wang, Haiyu Zhang, Jiahao Li, Hanqi Li, Qiuyu Chen, Dongyu Han, Jialiang Liu, Lin Lv, Jie Xiong, Keying Yuan, Xianpeng Wei, Siqi Sheng, Fukai Liu, Yuanqi Shi, Zengxiang Dong, Yue Li   +16 more
wiley   +1 more source

Function of circulation system in the course of arterial hypertension treatment in patients with vibration disease

Терапевтический архив, 2003
Aim. To develop medicinal approaches to correction of hemodynamic disturbances in vibration disease (VD) associated with arterial hypertension. Material and methods.
L A Shpagina, S V Tretyakov, T V Voitovich   +2 more
doaj  

Pulmonary Function in Left Ventricular Failure, Including Cardiac Asthma

, 1957
Richard S. Cosby, Ellery C. Stowell, W Hartwig, Mary Mayo   +3 more
openalex   +1 more source