Results 131 to 140 of about 179,739 (339)

Microalbuminuria as an indicator for LVH severity in patients with primary hypertension

open access: yesJournal of Family Medicine and Primary Care
Background: Hypertension is among the most complex global public health concerns. Hypertension and kidney diseases share a strong correlation. The existence of microalbuminuria signifies early renal impairment.
Govind Tripathi   +3 more
doaj   +1 more source

Implications of increased left ventricular mass index on in-hospital outcomes in patients undergoing aortic valve surgery [PDF]

open access: bronze, 2001
Rajendra H. Mehta   +10 more
openalex   +1 more source

PCSK9 Loss‐of‐Function Disrupts Cellular Microfilament Network via LIN28A/HES5/JMY Axis in Neural Tube Defects

open access: yesAdvanced Science, EarlyView.
PCSK9 acts as a molecular chaperone promoting LIN28A lysosomal degradation. LIN28A elevates transcription factor HES5, increasing JMY expression. PCSK9 loss causes neural tube defects (NTDs) by disrupting the LIN28A/HES5/JMY axis, and high JMY disorganizes the neural progenitor cell microfilament network, leading to incomplete neural tube structure in ...
Xiaoshuai Li   +6 more
wiley   +1 more source

Hypertension and cardiac damage in pheochromocytoma and paraganglioma patients: a large-scale single-center cohort study

open access: yesBMC Cardiovascular Disorders
Background Hypertension (HT) is one of the most common manifestations in patients with catecholamine-secreting neuroendocrine tumors. Although the cardiovascular manifestations of these tumors have been described, there have been no large-scale ...
Yang Yu   +6 more
doaj   +1 more source

Preservation of ALYREF Phase Separation Mitigates Doxorubicin‐Induced Cardiomyocyte DNA Damage and Cardiotoxicity

open access: yesAdvanced Science, EarlyView.
Binding of Doxorubicin to ALYREF disrupts its phase‐separated condensate and induces DNA damage and apoptosis in cardiomyocytes Abstract The clinical utility of the anticancer agent doxorubicin (DOX) is limited by its dose‐dependent cardiotoxicity.
Xinlu Gao   +20 more
wiley   +1 more source

Acidosis Forces Fatty Acid Uptake and Metabolism in Cancer Cells Regardless of Genotype

open access: yesAdvanced Science, EarlyView.
This study demonstrates that biological acidosis, commonly observed in tumors and ischemic conditions, actively promotes the protonation of fatty acids, thereby facilitating the uptake of their neutral forms. Consequently, the preference for lipid metabolism in acid‐exposed cells does not arise from genetic reprogramming that prioritizes lipids as the ...
Sébastien Ibanez   +20 more
wiley   +1 more source

Tri-ponderal mass index and left ventricular hypertrophy in a cohort of caucasian children and adolescents with obesity

open access: yesItalian Journal of Pediatrics
Background Pediatric obesity is a global emerging burden for society; among its health-related consequences there are hypertension (HTN) and left ventricular hypertrophy (LVH).
Sara Vizzuso   +5 more
doaj   +1 more source

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