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Leg ulcers usually occur secondary to venous reflux or obstruction, but 20% of people with leg ulcers have arterial disease, with or without venous disorders. Between 1.5 and 3.0 in 1000 people have active leg ulcers. Prevalence increases with age to about 20 in 1000 people aged over 80 years.We conducted a systematic overview, aiming to answer the ...
Nelson, EA, Adderley, U
openaire +9 more sources
Introduction: Leg ulcer is the most common cutaneous manifestation of sickle cell disease (SCD). Asymmetric dimethylarginine (ADMA) inhibits nitric oxide synthase, reducing nitric oxide availability, and causing endothelial dysfunction.
Chiemelie Raluchukwu Onwasigwe +4 more
doaj +1 more source
Chronic venous leg ulcer represents a major issue for both patients and health-care provider being associated with impaired quality of life. We here report a case of non-healing venous ulcer over gaiter area of right leg.
Kalidas Rit +3 more
doaj +1 more source
Objectives To investigate factors that promote and prevent the use of compression therapy in people with venous leg ulcers.Design Qualitative interview study with nurses using the Theoretical Domains Framework (TDF).Setting Three National Health Service ...
Jane Griffiths +7 more
doaj +1 more source
Martorell’s ulcer: a literature review and own clinical observation
Introduction. Martorell’s ulcer is a rather rare pathology that occurs exclusively in patients with long-term and poorly controlled arterial hypertension and continues to be one of the poorly studied areas of modern surgery.
B. V. Boldin +4 more
doaj +1 more source
Marjolin's Ulcers at a University Teaching Hospital in Northwestern Tanzania: A Retrospective Review of 56 Cases. [PDF]
Marjolin's ulcer is a rare but highly aggressive squamous cell cancer that is most often associated with chronic burn wounds. Although many individual case reports exist, no comprehensive evaluation of Marjolin's ulcer patients has been conducted in our ...
Rambau, Peter +39 more
core +1 more source
Leg ulceration: An exploration of the role of socio-economic factors in the epidemiology, access to health care and outcomes. [PDF]
Background Tackling health inequalities has been a priority policy area for the NHS since the 1990’s. To date there has been scant research addressing this area in relation to leg ulcers, despite there being some evidence of inequalities in leg ulcer ...
Petherick, Emily
core
Objective We assessed the effectiveness of PrismRA to improve clinical outcomes among patients with rheumatoid arthritis (RA) initiating treatment with a biologic or targeted synthetic disease‐modifying antirheumatic drug (b/tsDMARD). Methods PrismRA incorporated 19 gene expression features and four clinical features to assess a patient's likelihood of
Fenglong Xie +3 more
wiley +1 more source
Platelet-rich-fibrin for venous leg ulcer therapy [PDF]
Background: Venous leg ulcer (VLU) is a chronic condition in the chronic venous insufficiency clinical spectrum. It’s becoming a burden because of its chronicity, slower wound healing, accumulated high cost, and treatment is a challenging task.
Rachmani, Karin +2 more
core +2 more sources
From Adult to Adolescent: Alignment in Clinical Trials and Outcomes in Axial Spondyloarthritis
Spondyloarthritis (SpA) is a group of chronic inflammatory diseases encompassing axial and peripheral forms, with up to 20% of patients developing symptoms before age 16. Despite this substantial pediatric burden, treatment options for juvenile‐onset SpA (JSpA), particularly those with axial disease (axJSpA), remain limited.
Pamela F. Weiss +9 more
wiley +1 more source

