Results 41 to 50 of about 48,218 (287)

Gardiquimod Nanoemulsion Targets Cutaneous Leishmaniasis Lesions Reducing Systemic Toxicity and Parasite Burden

Advanced Healthcare Materials, EarlyView.
Nanoemulsion delivery of a TLR7 agonist enhances safety and promotes colocalization with Leishmania‐infected macrophages in skin lesions, enabling a ∼2‐log reduction in parasite burden. However, tissue‐level constraints and TLR‐driven regulatory feedback generate a mixed immune response that limits complete parasite clearance.
Carmen Palomino‐Cano, M. Carmen Mera‐Delgado, Esther Moreno, Esther Larrea, Lecnia Aguirre, Jonathan Miguel Zanatta, Sónia Barros‐Carvalho, Iola F. Duarte, Ricardo Silvestre, Juan M. Irache, Javier Carrión, Socorro Espuelas   +11 more
wiley   +1 more source

Secondary bacterial infections of buruli ulcer lesions before and after chemotherapy with streptomycin and rifampicin [PDF]

, 2013
Buruli ulcer (BU), caused by Mycobacterium ulcerans is a chronic necrotizing skin disease. It usually starts with a subcutaneous nodule or plaque containing large clusters of extracellular acid-fast bacilli.
Kwabena Quenin-Fosu, Gerd Pluschke, Newman Mercy, Ruf, Marie-Thérèse, Cynthia Kwakye-Maclean (349465), Grace S. Kpeli, Asan-Ampah, Kobina, Mercy Newman (409617), Kwabena Quenin-Fosu (335716), Marie-Thérèse Ruf (2280196), Isaac Lamptey, Kwakye-Maclean Cynthia, Mercy Newman, Albert Paintsil (409614), Kpeli Grace S., Cynthia Kwakye-Maclean, Grace S. Kpeli (409612), Isaac Lamptey (409615), Dorothy Yeboah-Manu, Benjamin Anku, Pluschke, Gerd, Yeboah-Manu, Dorothy, Evelyn Owusu-Mireku, Marie-Thérèse Ruf, Dorothy Yeboah-Manu (120059), Grace S Kpeli, Anku Benjamin, Albert Paintsil, Owusu-Mireku Evelyn, Evelyn Owusu-Mireku (409613), Quenin-Fosu Kwabena, Owusu-Mireku, Evelyn, Lamptey, Isaac, Paintsil, Albert, Quenin-Fosu, Kwabena, Benjamin Anku (409616), Ruf Marie-Thérèse, Pluschke Gerd, Kwakye-Maclean, Cynthia, Gerd Pluschke (7855), Kobina Asan-Ampah (335715), Anku, Benjamin, Asan-Ampah Kobina, Yeboah-Manu Dorothy, Paintsil Albert, Kpeli, Grace S., Newman, Mercy, Lamptey Isaac, Kobina Asan-Ampah   +48 more
core   +1 more source

Modulus‐Switchable Miniature Robots for Biomedical Applications: A Review

Advanced Robotics Research, EarlyView.
Materials, robot designs, proof‐of‐concept functions, and biomedical applications of modulus‐switchable miniature robots. Miniature soft robots have shown great potential in biomedical applications due to their excellent controllability and suitable mechanical properties in biological environments.
Chunyun Wei, Yibin Wang, Jiangfan Yu
wiley   +1 more source

Epidemiology of chronic leg ulcer

Minia Journal of Medical Research
Background: Chronic ulcer is a chronic wound that shows no tendency to heal after 3 months of appropriate treatment or is still not fully healed at 12 months.
Mohammad Abdel-Megid EL Khayyat, Mahmoud Ahmed Montaser, Momen Mostafa Elsanadiki, Hayam Ahmed Haridy   +3 more
doaj   +1 more source

Community Nurses' Judgement and Decision Making for the Management of Venous Leg Ulceration [PDF]

, 2013
Management of leg ulceration is an important part of community nurses’ workload but previous evidence suggests the quality of diagnosis and treatment of venous leg ulceration may be below that which should be expected.
Adderley, Una
core  

Microfluidic Valve‐Integrated Garment for Smooth Sequential Gradient Mechanotherapy

Advanced Intelligent Systems, EarlyView.
We present a soft wearable sleeve that delivers smooth, gap‐free compression using overlapping air‐filled actuators and tiny microfluidic valves. The system reduces bulk, lowers power needs, and uses a smartphone‐sized control box. It can provide sequential gradient compression, gradient pressure holding, and fast deflation, supporting more portable ...
Run Ze Gao, Chen Xi Huang, Drew M. Werbowski, Jacqueline Mary Kormylo, Clark R. Dickerson, Carolyn L. Ren   +5 more
wiley   +1 more source

Accounting for animal health in efficiency analysis: An application to Swedish dairy farms

American Journal of Agricultural Economics, EarlyView.
Abstract Poor animal health is a central concern in modern livestock production. Despite the necessity to incorporate animal health in efficiency analysis, the theoretical and empirical developments are limited on this subject. This article appropriately characterizes the axiomatic properties of animal health within a production framework.
Frederic Ang, Enoch Owusu‐Sekyere, Karin Alvåsen, Helena Hansson   +3 more
wiley   +1 more source

Internal consistency and reliability of the Swiss-French translation of the venous leg ulcer self efficacy tool (VeLUSET)

BMJ Open, 2019
Objective This study was conducted to assess the psychometric properties of the translated and adapted Venous Leg Ulcer Self Efficacy Tool (VeLUSET) in the new cultural context.Design Validation studySetting Three outpatient clinics in Western ...
Sebastian Probst, Mathieu Turcotte, Monika Buehrer Skinner   +2 more
doaj   +1 more source

Clinical Outcomes and Patient Experiences With Celiprolol Therapy in Vascular Ehlers–Danlos Syndrome: The First Non‐European Cohort

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Vascular Ehlers–Danlos syndrome (vEDS) is a hereditary connective tissue disorder caused by heterozygous pathogenic variants in COL3A1. European studies have shown that celiprolol may reduce the risk of life‐threatening vascular events, but outcomes in non‐European populations and the therapy's psychological impact remain unclear. We conducted
Megumi Furuhata‐Yoshimura, Tomomi Yamaguchi, Tomoki Kosho   +2 more
wiley   +1 more source

Neoplastic Leg Ulcers

Dermatopathology, 2018
Skin biopsy is an important procedure for a correct diagnosis of varying skin conditions, from inflammatory to neoplastic diseases. Nevertheless, some authors still consider this procedure a high risk in patients affected by leg ulcers (LUs) and prefer reserving it for selected cases.
Sacchelli, Lidia, Baraldi, Carlotta, Misciali, Cosimo, Dika, Emi, Ravaioli, Giulia Maria, Fanti, Pier Alessandro   +5 more
openaire   +3 more sources