Results 51 to 60 of about 1,567,590 (345)
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
The Dworkin's Criticism About Legal Positivism and the Construction of the Concept of Discretion
Revista Brasileira de Filosofia do Direito, 2015 Known as "Hart-Dworkin Debate," the clash of opinions between these two authors generated intense discussion about legal positivism and theories that seek to refute its core arguments.
Pedro D'Angelo da Costa
doaj +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background Poststroke fatigue (PSF) and frailty share substantial overlap in their manifestations, yet previous research has yielded conflicting results due to the use of heterogeneous frailty assessment tools. Objective To evaluate the independent impact of frailty on PSF using a unified measurement system (Tilburg Frailty Indicator, TFI ...
Chuan‐Bang Chen +6 more
wiley +1 more source
The Influence of Positivism and Empirism in The Enforcement of Islamic Inheritance Law in Indonesia
Substantive Justice International Journal of LawPositivism and empiricism are modern paradigms become the basic guidelines for the schools of legal philosophy, namely legal positivism and legal realism.
Jamrud Qomaruz Zaman +4 more
doaj +1 more source
Journal of Law and Legal Reform, 2021 Law is a rule or means in the administration of the state, in order to achieve an orderly, safe and secure life, the rights of the community are required. According to positivism, law is an order from those who hold the highest power or hold sovereignty.
Kartika Nur Cahyani
doaj +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Mutations in myelin regulatory factor (MYRF) are linked to demyelinating disorders. We report a 38‐year‐old male who developed acute symmetric leukoencephalopathy mimicking a stroke following an influenza A virus infection. While clinical symptoms markedly improved with corticosteroids, MRI revealed persistent white matter lesions, contrasting
Jinghan Hu +5 more
wiley +1 more source
Cuadernos Electrónicos de Filosofía del Derecho, 2022 In this paper I will expose what I consider to be the appropriate meaning of Fuller's theses on the internal morality of law. After having argued that the thesis of internal morality of law does not say much about the connection between law and morality ...
Antonio Manuel Peña Freire
doaj +1 more source
Jhon Austin's Positivism Legal Policy: Convergence of Natural Law
International Journal of Multicultural and Multireligious Understanding, 2021 Legal positivism is influenced by natural law from Ancient Greece, natural law comes from God to regulate human life. Humans were created by reason by God to make rules, John Austin stated that to make a rule sourced from orders or policies in the field ...
Arief Budiono +3 more
semanticscholar +1 more source
Frailty Exacerbates Disability in Progressive Multiple Sclerosis
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background To evaluate frailty in severe progressive multiple sclerosis (PMS) and to investigate the underlying mechanisms. Methods This prospective, cross‐sectional, multicenter study enrolled a late severe PMS group requiring skilled nursing (n = 53) and an age, sex, and disease duration‐matched control PMS group (n = 53).
Taylor R. Wicks +10 more
wiley +1 more source
COMMON ISSUES OF NATIONAL AND ANGLO-AMERICAN (ANALYTICAL) LEGAL POSITIVISM
Правовое государство: теория и практикаThe article examines the issue of finding the basis for common ground and scientific dialogue between national legal positivism and analytical positivism represented in common law countries.
GORBUNOV Maxim Dmitrievich
doaj +1 more source