Results 31 to 40 of about 31,494 (173)

Adverse Reactions Identified after Approval of Novel Medicines: Analysis of 339 New Molecular Entities and Therapeutic Biologics

Clinical Pharmacology &Therapeutics, EarlyView.
Postmarketing safety surveillance data identify safety issues not identified in preapproval clinical trials. We describe the frequency of new safety issues overall and by labeling section and the relationship of the most commonly added safety issues with the cumulative number of prescriptions dispensed via retail pharmacies.
Ellen Pinnow, Brendan Day, Esther H. Zhou, Corinne Woods, Nana Dwumfour, Jenni Y. Lee, Ilynn Bulatao, Sanae Cherkaoui, Manish Kalaria, Sonja Brajovic, Nabila Sadiq, Farideh Sistani, Maggie Lee, Grace Chai, Gerald Dal Pan   +14 more
wiley   +1 more source

Uncovering Gaps in Knowledge: A Survey of Belgian General Practitioners’ Awareness of Legionnaires’ Disease Diagnostic Testing

Infectious Disease Reports
Background: The incidence of Legionnaires’ disease (LD) is increasing steadily in Europe. Its early diagnosis by general practitioners (GPs) is crucial for better patient outcomes. Study objectives: This study assessed Belgian GPs’ knowledge about LD and
Marco Moretti, Julien Van Nedervelde, Robin Vanstokstraeten, Lucie Seyler, Fedoua Echahidi, Benoit Prevost, Delphine Martiny, Ingrid Wybo, Charlotte Michel   +8 more
doaj   +1 more source

Toward understanding the catalytic mechanism for two classes of bacterial phospholipid N‐methyltransferases

The FEBS Journal, EarlyView.
Phospholipid N‐methyltransferases (Pmts) synthesize phosphatidylcholine in many bacteria. In this study, we compared the catalytic mechanisms of two bacterial Pmt classes: the Rhodobacter (R‐) and the Sinorhizobium (S‐) type. Representative enzymes for each class were derived from Rubellimicrobium thermophilum and Agrobacterium tumefaciens ...
Irina Shevyreva, Lena Sophie Fritsch, Leander Mika Koch, Anton Effing, Meriyem Aktas, Franz Narberhaus   +5 more
wiley   +1 more source

Legionella pneumophila pneumonia in South Eastern Sydney: diagnosis, prognosis and public health outcomes

Internal Medicine Journal, EarlyView.
Abstract Background Legionellosis causes more severe disease than other aetiologies of community‐acquired pneumonia (CAP). Early recognition and treatment of Legionella pneumonia reduce mortality. Urinary antigen testing (UAT) has facilitated rapid and reliable diagnosis of Legionella pneumonia. Aims The aims of this study were as follows: (i) identify
Sue Qian, Nickson Ning, Kelli Snyders, Misha Klingstrom, Pam Konecny, Vicky Sheppeard, Rachael Roberts, Georgia Shimmin, Robert Stevens, Richard Sullivan   +9 more
wiley   +1 more source

Genomic surveillance of STEC/EHEC infections in Germany 2020 to 2022 permits insight into virulence gene profiles and novel O-antigen gene clusters

International Journal of Medical Microbiology
Shiga toxin-producing E. coli (STEC), including the subgroup of enterohemorrhagic E. coli (EHEC), are important bacterial pathogens which cause diarrhea and the severe clinical manifestation hemolytic uremic syndrome (HUS).
Angelika Fruth, Christina Lang, Tobias Größl, Thomas Garn, Antje Flieger   +4 more
doaj   +1 more source

Identifying the function of genes involved in excreted vesicle formation in Acanthamoeba castellanii containing Legionella pneumophila

Parasites & Vectors, 2023
Background Legionella spp. can survive and replicate inside host cells such as protozoa and macrophages. After enough growth, Legionella is released from the host cells as free legionellae or Legionella-filled vesicles. The vesicles support Legionella to
Min-Jeong Kim, Eun-Kyung Moon, Hye-Jeong Jo, Fu-Shi Quan, Hyun-Hee Kong   +4 more
doaj   +1 more source

Premise plumbing bacterial communities in four European cities and their association with Legionella

Frontiers in Microbiomes, 2023
IntroductionLegionella species are Gram negative, facultative, intracellular bacteria found in natural and engineered water systems. Understanding the bacterial interactions underlying the success of Legionella in aquatic environments could be ...
Maria Scaturro, Maria Scaturro, Federica Del Chierico, Yair Motro, Angeliki Chaldoupi, Anastasia Flountzi, Anastasia Flountzi, Jacob Moran-Gilad, Jacob Moran-Gilad, Antonietta Girolamo, Thomai Koutsiomani, Bozena Krogulska, Diane Lindsay, Diane Lindsay, Renata Matuszewska, Georgios Papageorgiou, Katarzyna Pancer, Nikolaos Panoussis, Maria Cristina Rota, Søren Anker Uldum, Søren Anker Uldum, Emmanuel Velonakis, Dominique L. Chaput, Maria Luisa Ricci, Maria Luisa Ricci   +24 more
doaj   +1 more source

A Nutrient‐Responsive LuxR Regulator Orchestrates Effector Gene Expression Across the Legionella Genus

Molecular Microbiology, EarlyView.
LexR1 is a LuxR‐type regulator that links nutrient sensing to effector gene expression in Legionella. Activated by a casamino acid‐derived ligand, LexR1 directly controls multiple effector genes using a conserved regulatory element present in numerous putative effectors across different Legionella species.
Chen Adler, Gil Segal
wiley   +1 more source

Sodium levels and grazing pressure shape natural communities of the intracellular pathogen Legionella

Microbiome, 2023
Background Legionella are parasites of freshwater protozoa, responsible for Legionellosis. Legionella can be found in a variety of aquatic environments, including rivers, lakes, and springs, as well as in engineered water systems where they can ...
Oded Bergman, Yaron Be’eri-Shlevin, Shira Ninio   +2 more
doaj   +1 more source

Stagnation arising through intermittent usage is associated with increased viable but non culturable Legionella and amoeba hosts in a hospital water system

Frontiers in Cellular and Infection Microbiology, 2023
Hospital water systems are a significant source of Legionella, resulting in the potentially fatal Legionnaires’ disease. One of the biggest challenges for Legionella management within these systems is that under unfavorable conditions Legionella ...
Muhammad Atif Nisar, Kirstin E. Ros, Melissa H. Brown, Melissa H. Brown, Richard Bentham, Giles Best, Giles Best, James Xi, Jason Hinds, Harriet Whiley, Harriet Whiley   +10 more
doaj   +1 more source