Results 51 to 60 of about 31,494 (173)
PHLPP is neither a Phosphatase nor a Tumor Suppressor
PH domain leucine‐rich repeat protein phosphatases (PHLPP) have been described as Akt phosphatases and tumor suppressors for more than 20 years. Recent evidence, however, indicates that they are pseudophosphatases that lost catalytic activity more than 450 Mya. This article argues that new hypotheses are urgently needed to reorient the field.
Thomas A. Leonard
wiley +1 more source
Modelo de control y vigilancia en sanidad ambiental basados en sistemas de autocontrol
En el ámbito ambiental el control de los riesgos para la salud está experimentando cambios importantes en lo referente a su concepción y a la forma de gestión de los mismos desde lo servicios de salud pública. Tradicionalmente la Administración Sanitaria
Loreto Santa Marina Rodríguez +1 more
doaj +2 more sources
Legionella pneumophila is a freshwater opportunistic pathogen and the leading cause of severe pneumonia known as Legionnaires’ disease. It can be found in all water systems and survives in biofilms, free-living amoebae, and a wide variety of facilities ...
Giorgia Caruso +8 more
doaj +1 more source
Use of PCR for Diagnosis of Legionella Infection in Hematological Patients [PDF]
Objective. To assess efficacy of PCR for detection of Legionella in bronchoalveolar lavage (BAL) fluid obtained from hematological patients with pneumonia and acute respiratory failure. Materials and Methods.
Yatsyshina S.B. +5 more
doaj
Under physiological conditions, pathogenic stimuli activate TLR/IL1‐R signaling, triggering TOLLIP dissociation from IRAK1 and subsequent IRAK1 phosphorylation, TRAF6 ubiquitination, and NF‐κB activation. During SARS‐CoV‐2 infection, viral M protein binds TOLLIP and stabilizes the TOLLIP–IRAK1 complex, thereby suppressing NF‐κB signaling, impairing ...
Yabin Zhang +10 more
wiley +1 more source
On the role of cell chaining in the attenuation of a Listeria monocytogenes divIVA mutant
Listeria monocytogenes is a human pathogen invading nonphagocytic host cells, replicating within their cytosol, and spreading directly from cell to cell. These processes are mediated by specialized virulence factors but also depend on the DivIVA protein.
Sabrina Wamp +3 more
doaj +1 more source
An Indigenous‐led monitoring program was established in the South Island of New Zealand to improve local drinking water safety. Advanced sampling techniques were used to identify public health risks and provide assurance that remedial interventions were effective.
Connor Redmile +7 more
wiley +1 more source
A large German outbreak in 2011 was caused by a locus of enterocyte effacement (LEE)-negative enterohemorrhagic E. coli (EHEC) strain of the serotype O104:H4. This strain harbors markers that are characteristic of both EHEC and enteroaggregative E. coli (
Christina Lang +6 more
doaj +1 more source
The substitution of tap water with rainwater for evaporate cooling systems creates no disadvantage with regard to the microbial safety and might allow a reduction of financial and resource investments. ABSTRACT Climate change and an increasing global population are supposed to cause progressive water shortages in the future.
Nicole van Leuven +6 more
wiley +1 more source
How often is a work-up for
Background It is unclear how often patients with pneumonia are assessed for Legionella in endemic areas. Additionally, the sensitivity of the IDSA/ATS criteria for recommended Legionella testing is undefined.
Mermel Leonard A +2 more
doaj +1 more source

