Results 71 to 80 of about 104,885 (314)

Comparative efficacy and safety of anakinra and canakinumab in patients with VEXAS syndrome – an international multicenter study

Arthritis &Rheumatology, Accepted Article.
Objectives The aim of this study was to compare differences in clinical response, drug survival, and adverse event rates between anakinra and canakinumab in VEXAS syndrome. Methods This multicenter international study includes VEXAS patients from France, Israel, and Italy treated with IL1 inhibition (IL1i).
Tali Eviatar, Dafne Capelusnik, Corrado Campochiaro, Valentin Lacombe, Vincent Jachiet, Michael Zisapel, Iftach Sagy, Oshrat E. Tayer‐Shifman, David Ozeri, Shaye Kivity, Alessandro Tomelleri, Benjamin Terrier, Hagit Peleg, Thibault Comont, Karim Sacre, Pascal Woaye‐Hune, Laurent Arnaud, Estibaliz Lazaro, Vincent Grobost, Francois Lifermann, Maxime Samson, Samuel Ardois, Alice Garnier, Alexandre Maria, Alain Cantagrel, Aurore Meyer, Jean‐David Bouaziz, Mael Heiblig, Lorenzo Dagna, Elisa Diral, Olivier Kosmider, Ori Elkayam, Jérôme Hadjadj, Sophie Georgin‐Lavialle, Olivier Fain, Arsene Mekinian   +35 more
wiley   +1 more source

Genomic analysis of 38 Legionella species identifies large and diverse effector repertoires

Nature Genetics, 2016
Infection by the human pathogen Legionella pneumophila relies on the translocation of ∼300 virulence proteins, termed effectors, which manipulate host cell processes. However, almost no information exists regarding effectors in other Legionella pathogens.
D. Burstein, F. Amaro, T. Zusman, Ziv Lifshitz, Ofir Cohen, J. Gilbert, T. Pupko, H. Shuman, G. Segal   +8 more
semanticscholar   +1 more source

Internal Ubiquitin Electrophiles for Covalent Trapping and Inhibition of Deubiquitinases

ChemBioChem, EarlyView.
GA: Genetically encoded internal electrophiles in ubiquitin (Ub) enable the profiling of multivalent interaction interfaces, addressing a key limitation of current Ub‐based activity‐based probes. In this study, these probes capture a Ub–deubiquitinase interaction with minimal structural perturbation and serve as selective diUb probes that covalently ...
Nipuni M. Pannala, Rishi S. Patel, Abhijith Saseendran Anit, Debapriya Bhattacharya, Kristos Negron Teron, Bryon Drown, Rudi Fasan, Chittaranjan Das   +7 more
wiley   +1 more source

Whole genome sequence analysis reveals the broad distribution of the RtxA type 1 secretion system and four novel putative type 1 secretion systems throughout the Legionella genus. [PDF]

, 2020
Type 1 secretion systems (T1SSs) are broadly distributed among bacteria and translocate effectors with diverse function across the bacterial cell membrane. Legionella pneumophila, the species most commonly associated with Legionellosis, encodes a T1SS at
Brown, Connor L, Coil, David A, Eisen, Jonathan A, Garner, Emily, Jospin, Guillaume, Mukhopadhyay, Biswarup, Pruden, Amy J, Schwake, David O   +7 more
core   +2 more sources

Deubiquitination of phosphoribosyl-ubiquitin conjugates by phosphodiesterase-domain–containing Legionella effectors

Proceedings of the National Academy of Sciences of the United States of America, 2019
Significance Ubiquitination is a vital posttranslational modification in eukaryotes. A variety of microbial pathogens exploit this pathway during their infection. Legionella pneumophila, the causative bacterial pathogen of Legionnaires’ disease, has been
Min Wan, A. Sulpizio, A. Akturk, W. Beck, Michael C. Lanz, V. Faça, M. Smolka, Joseph P. Vogel, Y. Mao   +8 more
semanticscholar   +1 more source

Isolation of plasmids in Legionella pneumophila and Legionella-like organisms [PDF]

Infection and Immunity, 1981
Agarose gel electrophoresis was employed to screen nine strains of Legionella-like bacteria and one strain of Legionella pneumophila for the presence of extrachromosomal deoxyribonucleic acid. Cryptic plasmids with molecular weights ranging from 46.6 x 10(6) to 59.8 x 10(6) were found in three of the isolates examined.
Perry Mikesell, John W. Ezzell, Gregory B Knudson   +2 more
openaire   +3 more sources

Development and Validation of a High‐Throughput Screening Assay for the Legionella ADP‐Ribosyl Transferase SdeA

ChemBioChem, EarlyView.
We show the optimization and application of a fluorogenic assay to monitor Legionella SdeA activity in a High‐Throughput‐Screening campaign. Ubiquitination of proteins is one of the most crucial post‐translational modifications in eukaryotic cells, typically involving conjugation of ubiquitin to a lysine residue in a substrate using a three‐enzyme ...
Halana C. Vlaming, Vito Pol, Bjorn R. van Doodewaerd, Angeliki Moutsiopoulou, Paul P. Geurink, Robbert Q. Kim, Gerbrand J. van der Heden van Noort   +6 more
wiley   +1 more source

Presence of Legionellaceae in warm water supplies and typing of strains by polymerase chain reaction [PDF]

, 2001
Outbreaks of Legionnaire's disease present a public health challenge especially because fatal outcomes still remain frequent. The aim of this study was to describe the abundance and epidemiology of Legionellaceae in the human-made environment.
Brengelmann, F., Dunkelberg, H., Wiese, Jutta, Zietz, B.   +3 more
core   +1 more source

How often is a work-up for Legionella pursued in patients with pneumonia? A retrospective study

BMC Infectious Diseases, 2011
Background It is unclear how often patients with pneumonia are assessed for Legionella in endemic areas. Additionally, the sensitivity of the IDSA/ATS criteria for recommended Legionella testing is undefined.
Mermel Leonard A, Dupont Irene, Hollenbeck Brian   +2 more
doaj   +1 more source

Presence of Legionella spp. in cooling towers: the role of microbial diversity, Pseudomonas, and continuous chlorine application

bioRxiv, 2019
Legionnaire’s Disease (LD) is a severe pneumonia caused by Legionella pneumophila. Cooling towers are the main source of L. pneumophila during large outbreaks. Colonization, survival, and proliferation of L.
Kiran Paranjape, E. Bédard, L. Whyte, J. Ronholm, M. Prévost, S. Faucher   +5 more
semanticscholar   +1 more source