Results 121 to 130 of about 69,586 (312)

Are liquids an efficient vehicle of healthcare associated infections? A review of reported cases in Italy (2000- 2014) [PDF]

, 2016
INTRODUCTION: In the field of healthcare-associated infections (HCAIs), one of the most reported, studied and discussed sources of infections is water, partly due to its controllability, but also because healthcare facilities, especially hospitals ...
D'Alessandro, Daniela, Napoli, Christian, Nusca, Assunta   +2 more
core   +1 more source

Copanlisib in combination with rituximab and bendamustine for transplant‐ineligible relapsed/refractory diffuse large B‐cell lymphoma patients: Results from the phase II multicentre FIL Copa‐BR trial from Fondazione Italiana Linfomi (FIL)

British Journal of Haematology, Volume 207, Issue 2, Page 445-454, August 2025.
A phase II, single‐arm, multicentre trial was conducted by Fondazione Italiana Linfomi (FIL) to investigate the combination of copanlisib plus rituximab and bendamustine (copa‐BR) in transplant‐ and chimeric antigen receptor (CAR)‐T‐ineligible relapsed/refractory (R/R) diffuse large B‐cell lymphoma (DLBCL). Thirty‐seven patients were enrolled.
Mattia Novo, Pio Manlio Mirko Frascione, Alessia Castellino, Luigi Marcheselli, Samantha Deianira Dattoli, Margherita Vannucchi, Delia Rota‐Scalabrini, Alessandra Tucci, Guido Gini, Giuseppe Tarantini, Donato Mannina, Annalisa Arcari, Arcangelo Liso, Elisabetta Scarpa, Dario Marino, Michele Spina, Ausilia Gorgone, Nicola Di Renzo, Salvatrice Mancuso, Luigi Petrucci, Agostino Tafuri, Barbara Botto, Francesca Bonello, Elisa Santambrogio, Umberto Vitolo   +24 more
wiley   +1 more source

Legionella pneumophila strain associated with the first evidence of person-to-person transmission of Legionnaires’ disease: a unique mosaic genetic backbone [PDF]

, 2016
A first strong evidence of person-to-person transmission of Legionnaires' Disease (LD) was recently reported. Here, we characterize the genetic backbone of this case-related Legionella pneumophila strain ("PtVFX/2014"), which also caused a large outbreak
Borges, Vítor, Gomes, João P., Gonçalves, Paulo, Machado, Jorge, Nunes, Alexandra, Sampaio, Daniel A., Simões, Maria J., Vieira, Luís   +7 more
core   +1 more source

Spatiotemporal Regulation of a Legionella pneumophila T4SS Substrate by the Metaeffector SidJ

PLoS Pathogens, 2015
Modulation of host cell function is vital for intracellular pathogens to survive and replicate within host cells. Most commonly, these pathogens utilize specialized secretion systems to inject substrates (also called effector proteins) that function as ...
K. Jeong, J. Sexton, Joseph P. Vogel
semanticscholar   +1 more source

Late blight pathogen targets host Rab‐G3 GTPases with an atypical GTPase‐activating protein

Journal of Integrative Plant Biology, Volume 67, Issue 8, Page 2135-2150, August 2025.
The Phytophthora infestans RXLR effector Pi17063 functions as an atypical GTPase‐activating protein of host positive immune regulators, specifically the small GTPase NbRab‐G3. Pi17063 promotes the relocalization of NbRab‐G3 proteins to the cytoplasm, where they are inactive, disrupting the balance of the NbRab‐G3 switch and thus leading to enhanced ...
Song Liu, Liwen Ding, Xiong Liu, Xiaoxi Xing, Jinyang Li, Tiantian Yan, Yuli Huang, Yuan Liu, Yisa Wang, Xia Zhang, Zeming Liu, Xiyu Cao, Yuling Meng, Weixing Shan   +13 more
wiley   +1 more source

Molecular diversity and high virulence of Legionella pneumophila strains isolated from biofilms developed within a warm spring of a thermal spa. [PDF]

, 2013
International audienceABSTRACT: BACKGROUND: Several cases of legionellosis have been diagnosed in the same French thermal spa in 1986, 1994 and 1997. L.
Atlan, Danièle, Chaabna, Zineddine, Fontvieille, Dominique, Forey, Françoise, Gilbert, Christophe, Jarraud, Sophie, Reyrolle, Monique   +6 more
core   +3 more sources

Water heater temperature set point and water use patterns influence Legionella pneumophila and associated microorganisms at the tap

Microbiome, 2015
Lowering water heater temperature set points and using less drinking water are common approaches to conserving water and energy; yet, there are discrepancies in past literature regarding the effects of water heater temperature and water use patterns on ...
W. Rhoads, Pan Ji, A. Pruden, M. Edwards
semanticscholar   +1 more source

Case Report: Hematopoietic Stem Cell Transplantation to Treat Severe Acquired Aplastic Anemia in a Pediatric Kidney Transplant Recipient

Pediatric Transplantation, Volume 29, Issue 5, August 2025.
ABSTRACT Background Hematopoietic stem cell transplantation (HSCT) in solid organ transplant recipients has been reported in adults. However, data on children are scarce. We report a case of an allogeneic HSCT in a 14‐year‐old girl to treat idiopathic very severe aplastic anemia (SAA). Case Presentation The girl developed end‐stage renal disease at the
Gintarė Mierkienė, Goda Elizabeta Vaitkevičienė, Karolis Ažukaitis, Augustina Jankauskienė, Jelena Rascon   +4 more
wiley   +1 more source

Legionella colonization and 3D spatial location within a Pseudomonas biofilm

Scientific Reports
Biofilms are known to be critical for Legionella settlement in engineered water systems and are often associated with Legionnaire’s Disease events. One of the key features of biofilms is their heterogeneous three-dimensional structure which supports the ...
Ana Rosa Silva, Luis F. Melo, C. William Keevil, Ana Pereira   +3 more
doaj   +1 more source

Phagocytosis of Legionella pneumophila is mediated by human monocyte complement receptors. [PDF]

, 1987
We have examined receptors mediating phagocytosis of the intracellular bacterial pathogen, Legionella pneumophila. Three mAbs against the type 3 complement receptor (CR3), which recognizes C3bi, inhibit adherence of L.
Horwitz, MA, Payne, NR
core