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Legionella pneumophila can cause a potentially fatal form of humane pneumonia (Legionnaires' disease), which is most problematic in immunocompromised and in elderly people.
Martina Oder +5 more
doaj +1 more source
Coxiella burnetii Blocks Intracellular Interleukin-17 Signaling in Macrophages [PDF]
Coxiella burnetii is an obligate intracellular bacterium and the etiological agent of Q fever. Successful host cell infection requires the Coxiella type IVB secretion system (T4BSS), which translocates bacterial effector proteins across the vacuole ...
Clemente, Tatiana M. +5 more
core +1 more source
BackgroundThe detection rates of Legionella pneumophila in metro cooling tower water in various cities are relatively high, while studies investigating the trends of Legionella pneumophila pollution and analyzing its influencing factors are still limited.
Rong PENG +4 more
doaj +1 more source
Global analysis of gene expression reveals mRNA superinduction is required for the inducible immune response to a bacterial pathogen. [PDF]
The inducible innate immune response to infection requires a concerted process of gene expression that is regulated at multiple levels. Most global analyses of the innate immune response have focused on transcription induced by defined immunostimulatory ...
Barry, Kevin C +2 more
core +3 more sources
Type VI secretion: a beginner's guide [PDF]
Type VI secretion is a newly described mechanism for protein transport across the cell envelope of Gram-negative bacteria. Components that have been partially characterised include an IcmF homologue, the ATPase ClpV, a regulatory FHA domain protein and ...
Akeda +47 more
core +1 more source
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
Ecological distribution of Legionella pneumophila [PDF]
Bacteria were concentrated 500-fold from 20-liter water samples collected from 67 different lakes and rivers in the United States. The data suggest that Legionella pneumophila is part of the natural aquatic environment and that the bacterium is capable of surviving extreme ranges of environmental conditions.
Fliermans, C. B. +5 more
openaire +2 more sources
Phylogenetic analysis reveals an ancient gene duplication as the origin of the MdtABC efflux pump. [PDF]
The efflux pumps from the Resistance-Nodulation-Division family, RND, are main contributors to intrinsic antibiotic resistance in Gram-negative bacteria. Among this family, the MdtABC pump is unusual by having two inner membrane components.
Górecki, Kamil, McEvoy, Megan M
core +2 more sources
A semiconductor‐fabricated nanowell biosensor enables rapid, scalable, and highly reproducible detection of SARS‐CoV‐2 antigens from nasal swabs within ∼10 minutes. Clinical validation in 249 retrospective and 243 prospective patient samples demonstrates high sensitivity and specificity, minimal cross‐reactivity, and robust batch‐to‐batch ...
Yoo Min Park +11 more
wiley +1 more source
Legionella pneumophila-Derived Outer Membrane Vesicles Promote Bacterial Replication in Macrophages. [PDF]
The formation and release of outer membrane vesicles (OMVs) is a phenomenon of Gram-negative bacteria. This includes Legionella pneumophila (L. pneumophila), a causative agent of severe pneumonia. Upon its transmission into the lung, L.
Anna Lena Jung +5 more
doaj +1 more source

