Results 31 to 40 of about 117,949 (253)

Defining an epidemic:The body mass index in British and American obesity research 1960-2000 [PDF]

, 2014
Between the 1970s and the mid‐1990s the body mass index (BMI) became the standard means of assessing obesity both in populations and in individuals, replacing previously diverse and contested definitions of excess body weight.
Amsterdamska, Aronowitz, Aronowitz, Bacon, Baird, Baird, Berridge, Berridge, Berridge, Berridge, Bowker, Bray, Bray, Bray, British Nutrition Foundation (BNF), Busch, Campos, Craddock, Crawford, Department of Health (DoH), Department of Health and Social Security/Medical Research Council (DHSS/MRC), Desrosieres, Epstein, Fletcher, Fye, Gaesser, Gard, Garrow, Garrow, Garrow, Garrow, Government Office for Science, Hacking, Hacking, Hautvast, Hilgartner, James, James, Jasanoff, Jasanoff, Keys, Kromhout, Kuczmarski, Kuczmarski, Kuhn, Monaghan, National Institutes of Health Panel on Obesity, O'Connell, Oddy, Office of Health Economics, Oliver, Oppenheimer, Oppenheimer, Pickersgill, Pickersgill, Pringle, Rothstein, Royal College of Physicians, Scottish Intercollegiate Guidelines Network (SIGN), Sims, Smith, Timmermann, Timmermans, Timmermans, Timmermans, Tunstall-Pedoe, VanItalllie, West, WHO, WHO, World Health Organization (WHO)   +70 more
core   +1 more source

Disease and psychological status in ankylosing spondylitis. [PDF]

, 2006
Objectives. Psychological factors may be important in the assessment and management of ankylosing spondylitis (AS). Our primary objective was to describe associations between disease and psychological status in AS, using AS-specific assessment tools and ...
Goodacre, J. A., Goodacre, L., Grennan, D., Martindale, J., Smith, J., Sutton, Chris J   +5 more
core   +1 more source

Self-replicative mRNA-mediated generation of induced pluripotent stem cell line from a 1-year-old Leigh syndrome patient with mitochondrial DNA cytochrome b mutation

Stem Cell Research, 2021
Leigh syndrome is a progressive neurodegenerative disease due to defects in the mitochondrial genes, including mitochondrial DNA cytochrome b (MTCYB) mutation, that typically begins in infancy or early childhood.
Daryeon Son, Jie Zheng, In Yong Kim, Seungkwon You   +3 more
doaj   +1 more source

Epilepsy in Leigh Syndrome With Mitochondrial DNA Mutations

Frontiers in Neurology, 2019
Background: Leigh syndrome is a mitochondrial cytopathy that presents as a neurodegenerative disease with apparent manifestation in the central nervous system.
Sunho Lee, Ji-Hoon Na, Young-Mock Lee, Young-Mock Lee   +3 more
doaj   +1 more source

Head Trauma as a Precipitating Factor for Late-onset Leigh Syndrome: a Case Report

Archives of Academic Emergency Medicine, 2017
Leigh syndrome is a severe progressive neurodegenerative disorder with different clinical presentationsthat usually becomes apparent in the first year of life and rarely in late childhood and elderly years.
Farzad Ashrafi, Hossein Pakdaman, Mehran Arabahmadi, Behdad Behnam   +3 more
doaj   +1 more source

Leigh Syndrome: A Tale of Two Genomes

Frontiers in Physiology, 2021
Leigh syndrome is a rare, complex, and incurable early onset (typically infant or early childhood) mitochondrial disorder with both phenotypic and genetic heterogeneity.
Ajibola B. Bakare, Edward J. Lesnefsky, Edward J. Lesnefsky, Edward J. Lesnefsky, Shilpa Iyer   +4 more
doaj   +1 more source

Genotype–phenotype correlation in IARS2‐related diseases: A case report and review of literature

Clinical Case Reports, 2022
Isoleucyl‐tRNA synthetase 2 (IARS2) encodes mitochondrial isoleucine‐tRNA synthetase. Pathogenic variants in the IARS2 gene are associated with mitochondrial disease.
Jariya Upadia, Yuwen Li, Nicolette Walano, Stephen Deputy, Kelly Gajewski, Hans C. Andersson   +5 more
doaj   +1 more source

Neurological, Psychiatric, and Biochemical Aspects of Thiamine Deficiency in Children and Adults. [PDF]

, 2019
Thiamine (vitamin B1) is an essential nutrient that serves as a cofactor for a number of enzymes, mostly with mitochondrial localization. Some thiamine-dependent enzymes are involved in energy metabolism and biosynthesis of nucleic acids whereas others ...
Adams, Alfadhel, Alfadhel, Alfadhel, Aljabri, Anwar, Aronson, Arts, Attwell, Baio, Banka, Barennes, Benton, Bettendorff, Bettendorff, Biesecker, Brown, Butterworth, Butterworth, Butterworth, Calhau, Carney, Chandrakumar, Chen, Cheung, Chornyy, Chugani, Colbert, Croft, Day, De Meirleir, Fattal-Valevski, Fattal-Valevski, Fleming, Forouhi, Foulon, Foulon, Fraccascia, Fraccascia, Fraser, Frustaci, Fujita, Galvin, Ganapathy, Gangolf, Ganie, Ghaleiha, Gibson, Giulivi, Gold, Greenwood, Gu, Harel, Hiffler, Hilker, Inaba, Ishaque, Israels, Jankowska-Kulawy, Junior, Kamasak, Karabatsiakis, Kelley, Kerns, Khaw, Kitamura, Kornreich, Kril, Laforenza, Leichter, Lindhurst, Liu, Lonsdale, Lonsdale, Lonsdale, Lorber, Lu, Lukienko, Luxemburger, Lương, Ma, Magos, Mahajan, Mahmood, Martel, Martin, Mayr, McLure, Mergenthaler, Mezzar, Mimouni-Bloch, Molina, Mulholland, Mulle, Muoio, Murata, Nabokina, Nabokina, Nardone, Navarro, Nikseresht, Obrenovich, Oishi, Opdenakker, Ortega Garcia, Ortigoza-Escobar, Pepersack, Perez-Duenas, Plaitakis, Prabakaran, Prohaska, Rabie, Randle, Renthal, Rindi, Rindi, Robinson, Roust, Rubio-Lopez, Said, Schaller, Scrimshaw, Sequeira Lopes da Silva, Shi, Singleton, Siu, Skjeldal, Smidt, Society, Song, Sperringer, Spiegel, Stargrove, Subramanian, Subramanian, Sweet, Tabarki, Talwar, Thomson, Thornalley, van den Brink, Vasconcelos, Vernau, Vernau, Vimokesant, Watkins, Wendel, Whitfield, Whitfield, Wierzbicki, Williams, Yang, Zhang, Zhao, Zuccoli   +154 more
core   +2 more sources

Leigh syndrome: A rare mitochondrial disorder

Bangabandhu Sheikh Mujib Medical University Journal, 2016
Leigh syndrome is a rare, mitochondrial disorder of childhood . In most cases dysfunction of the respiratory chain enzymes is responsible for the disease. Raised lactate levels in blood and/or cerebrospinal fluid is noted.
Gopen Kumar Kundu, Amina Akhter, Shaheen Akhter, Md. Mizanur Rhaman   +3 more
doaj   +1 more source

Leigh syndrome global patient registry: uniting patients and researchers worldwide

Orphanet Journal of Rare Diseases, 2023
Background Leigh Syndrome (LS) is a rare genetic neurometabolic disorder, that leads to the degeneration of the central nervous system and subsequently, early death. LS can be caused by over 80 mutations in mitochondrial or nuclear DNA.
Sophia Zilber, Kasey Woleben, Simon C. Johnson, Carolina Fischinger Moura de Souza, Danielle Boyce, Kevin Freiert, Courtney Boggs, Souad Messahel, Melinda J. Burnworth, Titilola M. Afolabi, Saima Kayani   +10 more
doaj   +1 more source