Results 51 to 60 of about 117,949 (253)
Sexual and Reproductive Health of Young Men of Color: Analyzing and Interpreting the Data,The [PDF]
, 2006 In the late 1980's, due in part to the spread of HIV and chlamydia, data collection on adolescent sexual and reproductive health began to shift away from its focus on young females to include males.
Danielle Huff, Wilhelmina A. Leigh
core
Genetics and insurance in the United Kingdom 1995-2010: the rise and fall of scientific discrimination [PDF]
, 2012 Around the millennium there was extensive debate in the United Kingdom of the possible use of predictive genetic tests by insurance companies. Many insurance experts, geneticists and public policymakers appeared to believe that genetic test results would
Thomas, R. Guy
core +1 more source
Multimorbidity and Associations with Cognition and Alzheimer's Disease Biomarkers
Annals of Neurology, EarlyView.Objective Multimorbidity, the coexistence of 2 or more chronic conditions, has been linked to cognitive aging and Alzheimer's disease (AD) and AD‐related dementias, yet the mechanisms remain unclear. We aimed to examine the associations of multimorbidity with cognition and biomarkers across multiple mechanistic pathways.
Xiaqing Jiang +45 more
wiley +1 more source
Chinese Journal of Contemporary Neurology and NeurosurgeryObjective To retrospectively analyze the clinical, imaging, pathological and genotypic characteristics of one case of mitochondrial cytopathy with rare double mutation of mitochondrial gene.
XU Tian, SHI Zhi-hong, ZHAO Wen-juan
doaj +1 more source
Response to immunotherapy in a patient with adult onset Leigh syndrome and T9176C mtDNA mutation
Molecular Genetics and Metabolism Reports, 2016 Leigh syndrome is a mitochondrial disease caused by mutations in different genes, including ATP6A for which no known therapy is available. We report a case of adult-onset Leigh syndrome with response to immunotherapy.
Miguel Chuquilin +3 more
doaj +1 more source
Biomaterial design strategies for enhancing mitochondrial transplantation therapy
BMEMat, EarlyView.Biomaterials to facilitate mitochondrial transplantation therapy: biomaterials as barriers to protect mitochondria from pathophysiological microenvironments, like osmotic stress caused by the excessive concentration of calcium ion, reactive oxygen species, and advanced glycation end products; biomaterials integrating with biochemical cues to improve ...
Shaoyang Kang +12 more
wiley +1 more source
Epilepsia, EarlyView.Abstract Objective The thalamus is a key hub in seizure propagation, and its nuclei are emerging targets for neuromodulation. However, the contributions of individual nuclei to epileptic networks remain unclear, particularly in children, who are less studied than adults.
Xiyu Feng +11 more
wiley +1 more source
Direct conversion of human pluripotent stem cells into cranial motor neurons using a piggyBac vector [PDF]
, 2018 Human pluripotent stem cells (PSCs) are widely used for in vitro disease modeling. One of the challenges in the field is represented by the ability of converting human PSCs into specific disease-relevant cell types.
De Santis, Riccardo +5 more
core +2 more sources
Inherited metabolic epilepsies–established diseases, new approaches
Epilepsia Open, EarlyView.Abstract Inherited metabolic epilepsies (IMEs) represent the inherited metabolic disorders (IMDs) in which epilepsy is a prevailing component, often determining other neurodevelopmental outcomes associated with the disorder. The different metabolic pathways affected by individual IMEs are the basis of their rarity and heterogeneity.
Itay Tokatly Latzer, Phillip L. Pearl
wiley +1 more source
A rare mitochondrial disorder: Leigh sydrome - a case report
Italian Journal of Pediatrics, 2010 Leigh syndrome is a rare progressive neurodegenerative, mitochondrial disorder of childhood with only a few cases documented from India. The clinical presentation of Leigh syndrome is highly variable.
Shrikhande Dhananjay Y +4 more
doaj +1 more source