Results 1 to 10 of about 61,294 (317)

Therapeutic advances in leiomyosarcoma

Frontiers in Oncology, 2023
Leiomyosarcoma is an aggressive mesenchymal malignancy and represents one of the most common subtypes of soft tissue sarcomas. It is characterized by significant disease heterogeneity with variable sites of origin and diverse genomic profiles.
Kristine Lacuna, Sminu Bose, Matthew Ingham, Gary Schwartz   +3 more
doaj   +2 more sources

Primary Splenic Leiomyosarcoma With Metastasis in a Rhesus Monkey (Macaca mulatta). [PDF]

Vet Med Sci
Primary mesenchymal tumours of the spleen in non‐human primates are exceedingly rare. We report on a 13‐year‐old female rhesus monkey who had an enlarged liver, spleen and multiple lung masses. Macroscopic, microscopic and immunohistochemical examinations revealed a splenic leiomyosarcoma with widespread metastasis.
Starost MF.
europepmc   +2 more sources

PI3K/AKT/mTOR inhibition in combination with doxorubicin is an effective therapy for leiomyosarcoma. [PDF]

Journal of Translational Medicine, 2016
BackgroundLeiomyosarcoma (LMS) is a common type of soft tissue sarcoma that responds poorly to standard chemotherapy. Thus the goal of this study was to identify novel selective therapies that may be effective in leiomyosarcoma by screening cell lines ...
Al-Awar, Rima, Babichev, Yael, Boutros, Paul C, Datti, Alessandro, Dickson, Brendan C, Gladdy, Rebecca A, Isaac, Methvin, Kabaroff, Leah, Prakesch, Michael, Sun, Ren X, Uehling, David, Venier, Rosemarie   +11 more
core   +3 more sources

Gastric Metastasis from a Primary Renal Leiomyosarcoma [PDF]

Case Reports in Gastroenterology, 2012
Primary leiomyosarcoma of the kidney is rare. Here we report a case of metastasis of this tumor to the stomach. A 73-year-old man visited our hospital suffering from general weakness and intermittent tarry stools.
Satoshi Yodonawa, Isao Ogawa, Susumu Yoshida, Hiromichi Ito, Akinori Kato, Ryoko Kubokawa, Emika Tokoshima, Hiroaki Shimoyamada   +7 more
doaj   +4 more sources

A case of leiomyosarcoma originating from the azygos vein [PDF]

Thoracic Cancer
Leiomyosarcoma is a soft‐tissue sarcoma that accounts for less than 1% of all malignant tumors. Furthermore, leiomyosarcoma accounts for 6% of all soft tissue sarcomas, and leiomyosarcoma of azygos vein origin is extremely rare.
Masatoshi Shimura, Nobutaka Kobayashi, Masahisa Miyazawa   +2 more
doaj   +2 more sources

Prostate leiomyosarcoma treatment using three-dimensional reconstruction: a case report and literature review [PDF]

Journal of Men's Health, 2021
Background: Prostate sarcoma is a malignant tumor from the prostate stroma. However, its pathogenesis is unknown. This is a rare type of prostate tumor. Case Presentation: A rare case of prostate leiomyosarcoma has been described.
Zhu-Nan Xu, Tong Cai, Zhong-Bao Zhou, Ji-Tao Wu, Zhen-Li Gao   +4 more
doaj   +1 more source

The diagnosis, classification, and treatment of sarcoma in this era of artificial intelligence and immunotherapy

Cancer Communications, Volume 42, Issue 12, Page 1288-1313, December 2022., 2022
Abstract Soft‐tissue sarcomas (STS) represent a group of rare and heterogeneous tumors associated with several challenges, including incorrect or late diagnosis, the lack of clinical expertise, and limited therapeutic options. Digital pathology and radiomics represent transformative technologies that appear promising for improving the accuracy of ...
Amandine Crombé, Mathtieu Roulleau‐Dugage, Antoine Italiano   +2 more
wiley   +1 more source

Molecular testing of soft tissue tumors

Diagnostic Cytopathology, Volume 51, Issue 1, Page 12-25, January 2023., 2023
Abstract Background The diagnosis of soft tissue tumors is challenging, especially when the evaluable material procured is limited. As a result, diagnostic ancillary testing is frequently needed. Moreover, there is a trend in soft tissue pathology toward increasing use of molecular results for tumor classification and prognostication. Hence, diagnosing
Douglas Rottmann, Eman Abdulfatah, Liron Pantanowitz   +2 more
wiley   +1 more source

PLAG1‐rearrangment in a uterine leiomyosarcoma with myxoid stroma and heterologous differentiation

Genes, Chromosomes and Cancer, 2021
A variety of molecular alterations have been reported in uterine leiomyosarcomas, but most are considered nondiagnostic. There are, however, rare exceptions including PLAG1 rearrangement which has recently been identified in a subset of myxoid ...
S. Thiryayi, G. Turashvili, E. Latta, D. Swanson, Lei Zhang, C. Antonescu, B. Dickson   +6 more
semanticscholar   +1 more source

Unmet Medical Needs and Future Perspectives for Leiomyosarcoma Patients—A Position Paper from the National LeioMyoSarcoma Foundation (NLMSF) and Sarcoma Patients EuroNet (SPAEN)

Cancers, 2021
Simple Summary In this position paper, we aim to summarize state-of-the-art treatments for patients with leiomyosarcomas in order to identify knowledge gaps and current unmet needs, thereby guiding the community to design innovative clinical trials and ...
B. Kasper, Annie Achee, K. Schuster, R. Wilson, G. van Oortmerssen, R. Gladdy, Matthew L. Hemming, Paul H. Huang, M. Ingham, Robin L. Jones, S. Pollack, D. Reinke, R. Sanfilippo, S. Schuetze, N. Somaiah, B. V. Van Tine, B. Wilky, S. Okuno, J. Trent   +18 more
semanticscholar   +1 more source