Results 11 to 20 of about 52,437 (276)

Therapeutic advances in leiomyosarcoma

Frontiers in Oncology, 2023
Leiomyosarcoma is an aggressive mesenchymal malignancy and represents one of the most common subtypes of soft tissue sarcomas. It is characterized by significant disease heterogeneity with variable sites of origin and diverse genomic profiles.
Kristine Lacuna, Sminu Bose, Matthew Ingham, Gary Schwartz   +3 more
doaj   +2 more sources

Primary vaginal leiomyosarcoma: A case report emphasizing multidisciplinary care of a rare entity [PDF]

Radiology Case Reports
Leiomyosarcoma (LMS) is a rare malignant tumor derived from smooth muscle cells. It usually occurs in the uterine cavity, other localizations, such as vaginal leiomyosarcoma, are atypical.
Fadoua Jebrouni, Hanan Bailal, Mouhsine Omari, Kaouthar Khater, Asmae Bali, Ouissam Al Jarroudi, Sami Aziz Brahmi, Said Afqir   +7 more
doaj   +2 more sources

Great saphenous vein leiomyosarcoma: a rare case report and literature review [PDF]

Frontiers in Oncology
Great saphenous vein leiomyosarcoma is an extremely rare tumor clinically, which is often misdiagnosed as superficial venous thrombosis due to atypical clinical manifestations.
Ying Liu, Bin Dong, Chunjie Hou, Litao Sun, Genshan He, Qiaohong Hu   +5 more
doaj   +2 more sources

Prostate leiomyosarcoma treatment using three-dimensional reconstruction: a case report and literature review [PDF]

Journal of Men's Health, 2021
Background: Prostate sarcoma is a malignant tumor from the prostate stroma. However, its pathogenesis is unknown. This is a rare type of prostate tumor. Case Presentation: A rare case of prostate leiomyosarcoma has been described.
Zhu-Nan Xu, Tong Cai, Zhong-Bao Zhou, Ji-Tao Wu, Zhen-Li Gao   +4 more
doaj   +1 more source

Prognosis and Follow-Up Recommendations for Subcutaneous and Dermal Leiomyosarcoma: Local Recurrence, Metastasis, and Overall Survival in a Danish Nationwide Cohort of 661 Patients. [PDF]

J Surg Oncol
ABSTRACT Background and Objectives The prognostic differences between subcutaneous leiomyosarcoma and dermal leiomyosarcoma are not well defined due to limited cohort sizes and insufficient follow‐up in prior studies. This study aimed to investigate the clinicopathological features of subcutaneous and dermal leiomyosarcoma and estimate their 10‐year ...
Abebe K, Ørholt M, Bak EEF, Larsen A, Wagenblast AL, Schmidt G, Jensen DH, Petersen MM, Loya AC, Daugaard S, Herly M, Hornick JL, Mentzel T, Vester-Glowinski P.   +13 more
europepmc   +2 more sources

Cutaneous leiomyosarcoma: a 20-year retrospective study and review of the literature

Anais Brasileiros de Dermatologia, 2021
Background: Cutaneous leiomyosarcoma is a rare malignant neoplasm with muscular origin, representing 2%-3% of all cutaneous soft tissue sarcomas. Objectives: The aim of this study was to characterize clinicopathological features of patients diagnosed ...
Catarina Soares Queirós, Paulo Filipe, Luís Soares de Almeida   +2 more
doaj   +1 more source

Lineage-defined leiomyosarcoma subtypes emerge years before diagnosis and determine patient survival

Nature Communications, 2021
Leiomyosarcomas (LMS) are genetically heterogeneous tumors differentiating along smooth muscle lines. Currently, LMS treatment is not informed by molecular subtyping and is associated with highly variable survival. While disease site continues to dictate
Nathaniel D. Anderson, Y. Babichev, F. Fuligni, Federico Comitani, M. Layeghifard, Rosemarie E. Venier, S. Dentro, Anant Maheshwari, S. Guram, Claire Wunker, J. D. Thompson, K. Yuki, Huayun Hou, M. Zatzman, Nicholas Light, M. Bernardini, J. Wunder, I. Andrulis, P. Ferguson, A. Razak, C. Swallow, J. Dowling, R. Al-Awar, R. Marcellus, M. Rouzbahman, M. Gerstung, D. Durocher, Ludmil B. Alexandrov, B. Dickson, R. Gladdy, A. Shlien   +30 more
semanticscholar   +1 more source

Unmet Medical Needs and Future Perspectives for Leiomyosarcoma Patients—A Position Paper from the National LeioMyoSarcoma Foundation (NLMSF) and Sarcoma Patients EuroNet (SPAEN)

Cancers, 2021
Simple Summary In this position paper, we aim to summarize state-of-the-art treatments for patients with leiomyosarcomas in order to identify knowledge gaps and current unmet needs, thereby guiding the community to design innovative clinical trials and ...
B. Kasper, Annie Achee, K. Schuster, R. Wilson, G. van Oortmerssen, R. Gladdy, Matthew L. Hemming, Paul H. Huang, M. Ingham, Robin L. Jones, S. Pollack, D. Reinke, R. Sanfilippo, S. Schuetze, N. Somaiah, B. V. Van Tine, B. Wilky, S. Okuno, J. Trent   +18 more
semanticscholar   +1 more source

PLAG1‐rearrangment in a uterine leiomyosarcoma with myxoid stroma and heterologous differentiation

Genes, Chromosomes and Cancer, 2021
A variety of molecular alterations have been reported in uterine leiomyosarcomas, but most are considered nondiagnostic. There are, however, rare exceptions including PLAG1 rearrangement which has recently been identified in a subset of myxoid ...
S. Thiryayi, G. Turashvili, E. Latta, D. Swanson, Lei Zhang, C. Antonescu, B. Dickson   +6 more
semanticscholar   +1 more source

A differential diagnosis between uterine leiomyoma and leiomyosarcoma using transcriptome analysis

BMC Cancer, 2023
Background The objective of this study was to estimate the accuracy of transcriptome-based classifier in differential diagnosis of uterine leiomyoma and leiomyosarcoma.
Kidong Kim, Sarah Kim, TaeJin Ahn, Hyojin Kim, So-Jin Shin, Chel Hun Choi, Sungmin Park, Yong-Beom Kim, Jae Hong No, Dong Hoon Suh   +9 more
doaj   +1 more source