Results 21 to 30 of about 552,685 (276)

The upper mesosphere and lower thermosphere wind field over Central Europe from 1994 through 1996 obtained from a joint analysis of LF windprofiler and MF radar measurements

Meteorologische Zeitschrift, 1997
The mesopause region wind field over Central Europe has been continually recorded by daily low-frequency total reflection wind measurements using commercial radio transmitters at the Collm Observatory of the University of Leipzig, and by medium-frequency
R. Schminder, Ch. Jacobi, D. Kürschner, P. Hoffmann, D. Keuer, W. Singer   +5 more
doaj   +1 more source

Quasistationary collapse to the extreme Kerr black hole

, 2004
It is shown that the extreme Kerr black hole is the only candidate for a black hole limit of rotating fluid bodies in equilibrium.Comment: 6 pages, submitted to Annalen der Physik ...
Meinel, Reinhard
core   +1 more source

Adeno‐associated virus serotype 2 capsid variants for improved liver‐directed gene therapy

Hepatology, EarlyView., 2022
Abstract Background and Aims Current liver‐directed gene therapies look for adeno‐associated virus (AAV) vectors with improved efficacy. With this background, capsid engineering is explored. Whereas shuffled capsid library screenings have resulted in potent liver targeting variants with one first vector in human clinical trials, modifying natural ...
Nadja Meumann, Marti Cabanes‐Creus, Moritz Ertelt, Renina Gale Navarro, Julie Lucifora, Qinggong Yuan, Karin Nien‐Huber, Ahmed Abdelrahman, Xuan‐Khang Vu, Liang Zhang, Ann‐Christin Franke, Christian Schmithals, Albrecht Piiper, Annabelle Vogt, Maria Gonzalez‐Carmona, Jochen T. Frueh, Evelyn Ullrich, Philip Meuleman, Steven R. Talbot, Margarete Odenthal, Michael Ott, Erhard Seifried, Clara T. Schoeder, Joachim Schwäble, Leszek Lisowski, Hildegard Büning   +25 more
wiley   +1 more source

Die Baumkronenspinnen (Araneae) des Leipziger Auwaldes [PDF]

, 2012
The canopy spiders of the floodplain forest in Leipzig have become a focus of ecological studies in recent years. In 2006 we sampled 30 tree canopies in the ‘Burgaue’ nature reserve with pyrethrum knock-down fogging, recording 502 adult spiders belonging
Floren, Andreas, Otto, Stefan
core  

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Full Counting Statistics and Field Theory

, 2007
We review the relations between the full counting statistics and the field theory of electric circuits. We demonstrate that for large conductances the counting statistics is determined by non-trivial saddle-point of the field.
Ambegaokar, Averin, Bagrets, Belzig, Bylander, Cron, Devoret, Egger, Feigelman, Fujisawa, Galaktionov, Gogolin, Golubev, Grabert, Gustavsson, Ingold, Kane, Kindermann, Kindermann, Kosterlitz, Levitov, Levitov, Levy Yeyati, Matveev, Melsen, Muzykantskii, Nazarov, Nazarov, Nazarov, Nazarov, Nazarov, Nazarov, Nazarov, Nazarov, Reulet, Schön, Zinn-Justin   +36 more
core   +2 more sources

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Developing a Mobile Health Application to Communicate Adverse Drug Reactions – Preconditions, Assessment of Possible Functionalities and Barriers for Patients and Their General Practitioners

Journal of Multidisciplinary Healthcare, 2022
Ines Wakob,1,2 Gordian Lukas Schmid,3 Ingo Nöhring,3 Romy Elze,4 Ralf Sultzer,5 Thomas Frese,6 Susanne Schiek,1,2,* Thilo Bertsche1,2,* 1Clinical Pharmacy, Institute of Pharmacy, Medical Faculty, Leipzig University, Leipzig, Germany; 2Drug Safety
Wakob I, Schmid GL, Nöhring I, Elze R, Sultzer R, Frese T, Schiek S, Bertsche T   +7 more
doaj  

Toward a Nonlocal Theory of Gravitation [PDF]

, 2006
The nonlocal theory of accelerated systems is extended to linear gravitational waves as measured by accelerated observers in Minkowski spacetime. The implications of this approach are discussed.
Bohr, Chicone, Einstein, Hehl, Mashhoon, Mashhoon, Mashhoon, Ramos, Tricomi, Volterra   +9 more
core   +2 more sources

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source