Results 21 to 30 of about 66,420 (242)

Adeno‐associated virus serotype 2 capsid variants for improved liver‐directed gene therapy

Hepatology, EarlyView., 2022
Abstract Background and Aims Current liver‐directed gene therapies look for adeno‐associated virus (AAV) vectors with improved efficacy. With this background, capsid engineering is explored. Whereas shuffled capsid library screenings have resulted in potent liver targeting variants with one first vector in human clinical trials, modifying natural ...
Nadja Meumann, Marti Cabanes‐Creus, Moritz Ertelt, Renina Gale Navarro, Julie Lucifora, Qinggong Yuan, Karin Nien‐Huber, Ahmed Abdelrahman, Xuan‐Khang Vu, Liang Zhang, Ann‐Christin Franke, Christian Schmithals, Albrecht Piiper, Annabelle Vogt, Maria Gonzalez‐Carmona, Jochen T. Frueh, Evelyn Ullrich, Philip Meuleman, Steven R. Talbot, Margarete Odenthal, Michael Ott, Erhard Seifried, Clara T. Schoeder, Joachim Schwäble, Leszek Lisowski, Hildegard Büning   +25 more
wiley   +1 more source

Developing a Mobile Health Application to Communicate Adverse Drug Reactions – Preconditions, Assessment of Possible Functionalities and Barriers for Patients and Their General Practitioners

Journal of Multidisciplinary Healthcare, 2022
Ines Wakob,1,2 Gordian Lukas Schmid,3 Ingo Nöhring,3 Romy Elze,4 Ralf Sultzer,5 Thomas Frese,6 Susanne Schiek,1,2,* Thilo Bertsche1,2,* 1Clinical Pharmacy, Institute of Pharmacy, Medical Faculty, Leipzig University, Leipzig, Germany; 2Drug Safety
Wakob I, Schmid GL, Nöhring I, Elze R, Sultzer R, Frese T, Schiek S, Bertsche T   +7 more
doaj  

Enhancing Optoelectronic Properties in Phthalocyanine‐Based SURMOFs: Synthesis of ABAB Linkers by Avoiding Statistical Condensation with Tailored Building Blocks

Advanced Functional Materials, EarlyView.
A novel phthalocyanine (PC)‐based metal–organic framework (MOFs) is synthesized using ditopic PC linkers obtained through regioselective statistical condensation. The resulting MOF exhibits significant improvements in electronic absorption, thereby enhancing the material's performance in light harvesting and energy conversion.
Lukas S. Langer, Mareen Stahlberger, Xiaojing Liu, Yi Luo, Niklas E. Häußermann, Puja Singhvi, Yidong Liu, Olaf Fuhr, Martin Nieger, Lars Heinke, Thomas Heine, Christof Wöll, Stefan Bräse   +12 more
wiley   +1 more source

COVID-19 pandemic and urban green spaces: Shifting usage behaviours and perceptions in Leipzig (Germany)?

Moravian Geographical Reports
Crises such as the COVID-19 pandemic challenge some established human-landscape interactions notably. In this article, we analyse whether the pandemic had an impact on the perception of urban green spaces (UGS) and usage behaviours in Leipzig, Germany ...
Sielaff Hendrik, Bundschuh Lukas, Moritz Lena, Taubmann Clarissa, Badack Joanne, Weinhold Klara, Hübscher Marcus   +6 more
doaj   +1 more source

Invasive Growth of Ailanthus altissima Trees is Associated with a High Rate of Sensitization in Atopic Patients

Journal of Asthma and Allergy, 2022
Freerk Prenzel1,2 *, Regina Treudler1,3 *, Tobias Lipek,1,2 Maike vom Hove,1,2 Paula Kage,1,3 Simone Kuhs,1,4 Thorsten Kaiser,1,4 Maximilian Bastl,5 Jan Bumberger,6– 8 Jon Genuneit,9,10 Thomas Hornick,8,11 Stefan Klotz,8,12 Julia Zarnowski,1,3 ...
Prenzel F, Treudler R, Lipek T, vom Hove M, Kage P, Kuhs S, Kaiser T, Bastl M, Bumberger J, Genuneit J, Hornick T, Klotz S, Zarnowski J, Boege M, Zebralla V, Simon JC, Dunker S   +16 more
doaj  

Rational Fine‐Tuning of MOF Pore Metrics: Enhanced SO2 Capture and Sensing with Optimal Multi‐Site Interactions

Advanced Functional Materials, EarlyView.
A pore tuning strategy to amplify the multi‐site MOF‐SO2 interactions is proposed to achieve an enhanced trace SO2 capture and chemiresistive sensing in highly stable isostructural DMOFs by annelating benzene rings. This work provides a facile strategy to achieve tailor‐made stable MOF materials for specific multifunctional applications.
Shanghua Xing, Abdulrahman Mohabbat, István Boldog, Jens Möllmer, Marcus Lange, Yulyan Haiduk, Tobias Heinen, Vladimir Pankov, Oliver Weingart, Christoph Janiak   +9 more
wiley   +1 more source

Koenen, Erik (Hrsg.) (2016): Die Entdeckung der Kommunikationswissenschaft. 100 Jahre kommunikationswissenschaftliche Fachtradition in Leipzig: Von der Zeitungskunde zur Kommunikations- und Medienwissenschaft.

Studies in Communication Sciences, 2017
Der von Erik Koenen herausgegebene Band, der im Kontext des hundertjährigen Jubiläums des Leipziger Instituts für Kommunikations- und Medienwissenschaft (IfKMW) entstanden ist, zeichnet auf einer ersten Ebene die organisatorische Entwicklung des ...
Mike Meißner
doaj   +1 more source

Treatment of Supraophthalmic Internal Carotid Artery Fenestration with an Associated Aneurysm via Flow Diversion: A Case Report

International Medical Case Reports Journal, 2021
Johannes Kasper,1 Ulf Nestler,1 Jürgen Meixensberger,1 Ulf Quäschling2 1Department of Neurosurgery, University Hospital Leipzig, Leipzig, 04103, Germany; 2Institute of Neuroradiology, Department of Diagnostic Medicine, University Hospital Leipzig ...
Kasper J, Nestler U, Meixensberger J, Quäschling U   +3 more
doaj  

siRNA Delivery via Cross‐Linked Gelatin Microparticles Enables Targeted Modulation of Osteogenic‐Vascular Cross‐Talk: An Advanced Human 3D in Vitro Test System for Therapeutic siRNA

Advanced Healthcare Materials, EarlyView.
Osteogenic‐angiogenic cross‐talk is a vital prerequisite for vascularized bone regeneration. In this study, we investigated the effects of siRNA‐mediated silencing of two inhibitory proteins, Chordin and WWP‐1, via CaP‐NP‐loaded gelatin microparticles in osteogenically differentiated microtissues.
Franziska Mitrach, Jonas Kubat, Stefan Simm, Alexandra H. Springwald, Burak Demir, Anton Liebezeit, Michael C. Hacker, Michaela Schulz‐Siegmund   +7 more
wiley   +1 more source

“Importing” the Enlightenment and “Enlightenment at the margins”. The example of Bohemia as a language and religious frontier, 1770-1800

Cornova
This contribution explores the hypothesis that 18th-century Bohemia, which was effectively a political and informational periphery directed from Vienna, also functioned – thanks to its geographical position and other factors and despite unfavourable ...
Daniela Tinková
doaj   +1 more source