Results 31 to 40 of about 295,484 (251)

Adeno‐associated virus serotype 2 capsid variants for improved liver‐directed gene therapy

Hepatology, EarlyView., 2022
Abstract Background and Aims Current liver‐directed gene therapies look for adeno‐associated virus (AAV) vectors with improved efficacy. With this background, capsid engineering is explored. Whereas shuffled capsid library screenings have resulted in potent liver targeting variants with one first vector in human clinical trials, modifying natural ...
Nadja Meumann, Marti Cabanes‐Creus, Moritz Ertelt, Renina Gale Navarro, Julie Lucifora, Qinggong Yuan, Karin Nien‐Huber, Ahmed Abdelrahman, Xuan‐Khang Vu, Liang Zhang, Ann‐Christin Franke, Christian Schmithals, Albrecht Piiper, Annabelle Vogt, Maria Gonzalez‐Carmona, Jochen T. Frueh, Evelyn Ullrich, Philip Meuleman, Steven R. Talbot, Margarete Odenthal, Michael Ott, Erhard Seifried, Clara T. Schoeder, Joachim Schwäble, Leszek Lisowski, Hildegard Büning   +25 more
wiley   +1 more source

Paradoxe Aushandlungen von Migration im Diskurs um die Leipziger Eisenbahnstraße Paradoxical negotiations of migration in discourses around the Eisenbahnstraße in the city of Leipzig

Raumforschung und Raumordnung, 2019
Verschiebungen bzw. wechselseitige Bedingtheiten von neuen gesellschaftlichen Ein- und Ausschlüssen im Prozess der Internationalisierung und Diversifizierung von Städten genauer zu betrachten, ist Ziel dieses Beitrags.
Wiest Karin, Kirndörfer Elisabeth
doaj   +1 more source

150 Years: The Leipzig Meteorological Conference, 1872, a Milestone in International Meteorological Cooperation

Meteorologische Zeitschrift, 2022
One hundred and fifty years ago, a meteorological conference was held in Leipzig as part of the anniversary meeting of the Society of German Natural Scientists and Physicians (Gesellschaft Deutscher Naturforscher und Ärzte), founded in Leipzig in 1822 ...
Michael Börngen, Thomas Foken
doaj   +1 more source

Refugees as Urban Stakeholders: Lessons From Reception of Ukrainians in German Cities

Urban Planning
This article examines how reception and participation practices shape urban futures in Berlin and Leipzig, highlighting Ukrainian refugees as agents of urban change.
Valeria Lazarenko, Annegret Haase
doaj   +1 more source

The upper mesosphere and lower thermosphere wind field over Central Europe from 1994 through 1996 obtained from a joint analysis of LF windprofiler and MF radar measurements

Meteorologische Zeitschrift, 1997
The mesopause region wind field over Central Europe has been continually recorded by daily low-frequency total reflection wind measurements using commercial radio transmitters at the Collm Observatory of the University of Leipzig, and by medium-frequency
R. Schminder, Ch. Jacobi, D. Kürschner, P. Hoffmann, D. Keuer, W. Singer   +5 more
doaj   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

COVID-19 pandemic and urban green spaces: Shifting usage behaviours and perceptions in Leipzig (Germany)?

Moravian Geographical Reports
Crises such as the COVID-19 pandemic challenge some established human-landscape interactions notably. In this article, we analyse whether the pandemic had an impact on the perception of urban green spaces (UGS) and usage behaviours in Leipzig, Germany ...
Sielaff Hendrik, Bundschuh Lukas, Moritz Lena, Taubmann Clarissa, Badack Joanne, Weinhold Klara, Hübscher Marcus   +6 more
doaj   +1 more source

Ambient‐Stable Transparent P‐Type CuI Transistors Via Room‐Temperature Pulsed Laser Deposition

Advanced Functional Materials, EarlyView.
An in situ PLD fabricated AlOx${\rm AlO}_x$/CuI/AlOx${\rm AlO}_x$ sandwich structure enables stable CuI TFTs with a field‐effect mobility of 2.3 ±$\pm$ 0.7 cm2${\rm cm}^{2}$ V−1${\rm V}^{-1}$ s−1${\rm s}^{-1}$ and excellent ambient stability. Complementary inverters based on CuI:Rb and ZnO:Al exhibit rail‐to‐rail voltage transfer characteristics and an
Yang Chen, Susanne Selle, Michael S. Bar, Michael Lorenz, Holger von Wenckstern, Marius Grundmann   +5 more
wiley   +1 more source

Dental Microwear Texture Analysis on Radular Teeth

Advanced Materials Interfaces, EarlyView.
3D microwear textures reveal how gastropod radular teeth respond to controlled abrasive contact. Distinct surface signatures distinguish regular abrasion from fracture‐dominated material removal, showing how mineralized coatings, fibrous cores, and substrate properties jointly shape wear and failure in a biological scraping interface.
Wencke Krings, Stanislav N. Gorb, Ellen Schulz‐Kornas   +2 more
wiley   +1 more source

Gate‐Induced Critical Current Modulation in W–C Nanowires: The Role of Fabrication

Advanced Materials Technologies, EarlyView.
Focused ion beam induced deposition (FIBID) enables precise control of superconducting W–C nanowire devices. Introducing a Ga+ focused ion beam (FIB) cleaning step reduces substrate damage and suppresses leakage currents, shifting gating thresholds to higher voltages.
Alba Arroyo‐Fructuoso, Gregor Hlawacek, Rosa Córdoba   +2 more
wiley   +1 more source