Results 21 to 30 of about 68,470 (244)

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Optimized Ex Vivo Human Liver Slice Culture Maintains Extended Viability and Function for Hepatotoxicity Testing

Advanced Science, EarlyView.
An optimized ex vivo human liver slice culture system preserves tissue architecture, hepatocyte function, and immune‐stromal complexity for at least five days. By refining slice thickness, oxygenation, air‐liquid interface, and extracellular matrix support, the platform enables human‐relevant hepatotoxicity testing and mechanistic studies, offering a ...
Huiche Feng, Cinzia Esposito, Andrej Benjak, Matthias S. Matter, Miriam Cieri, Camilla De Carlo, Philipp Sedlaczek, Fabian Haak, Mattia Marinucci, Gabriel Fridolin Hess, Otto Kollmar, Mairene Coto‐Llerena, Luca Di Tommaso, Visar Vela, Lukas Bubendorf, Luigi M. Terracciano, Charlotte K. Y. Ng, Salvatore Piscuoglio   +17 more
wiley   +1 more source

COVID-19 pandemic and urban green spaces: Shifting usage behaviours and perceptions in Leipzig (Germany)?

Moravian Geographical Reports
Crises such as the COVID-19 pandemic challenge some established human-landscape interactions notably. In this article, we analyse whether the pandemic had an impact on the perception of urban green spaces (UGS) and usage behaviours in Leipzig, Germany ...
Sielaff Hendrik, Bundschuh Lukas, Moritz Lena, Taubmann Clarissa, Badack Joanne, Weinhold Klara, Hübscher Marcus   +6 more
doaj   +1 more source

Developing a Mobile Health Application to Communicate Adverse Drug Reactions – Preconditions, Assessment of Possible Functionalities and Barriers for Patients and Their General Practitioners

Journal of Multidisciplinary Healthcare, 2022
Ines Wakob,1,2 Gordian Lukas Schmid,3 Ingo Nöhring,3 Romy Elze,4 Ralf Sultzer,5 Thomas Frese,6 Susanne Schiek,1,2,* Thilo Bertsche1,2,* 1Clinical Pharmacy, Institute of Pharmacy, Medical Faculty, Leipzig University, Leipzig, Germany; 2Drug Safety
Wakob I, Schmid GL, Nöhring I, Elze R, Sultzer R, Frese T, Schiek S, Bertsche T   +7 more
doaj  

MiR‐940 Suppresses Ferroptosis by Controlling Expression of Key Regulatory Genes

Advanced Science, EarlyView.
A CRISPR‐based screening identified miR‐940 as a critical suppressor of ferroptosis in cancer. By coordinating the downregulation of pro‐ferroptotic genes with the upregulation of GPX4, miR‐940 establishes a regulatory network that protects against ferroptosis and correlates with poor clinical outcomes in distinct cancer entities.
Andrea Kolak, Juliane Tschuck, Stefanie A. I. Weiß, Daniel Kaemena, Karolin Klimm, Ana Galhoz, Larissa Ringelstetter, Myles Fennell, Juliane Merl‐Pham, Anna Artati, Stefanie Strasser, Ralph Garippa, Michael Witting, Hans Zischka, Joel A. Schick, Stefanie M. Hauck, Michael P. Menden, Michelle Vincendeau, Brent R. Stockwell, Kamyar Hadian   +19 more
wiley   +1 more source

Koenen, Erik (Hrsg.) (2016): Die Entdeckung der Kommunikationswissenschaft. 100 Jahre kommunikationswissenschaftliche Fachtradition in Leipzig: Von der Zeitungskunde zur Kommunikations- und Medienwissenschaft.

Studies in Communication Sciences, 2017
Der von Erik Koenen herausgegebene Band, der im Kontext des hundertjährigen Jubiläums des Leipziger Instituts für Kommunikations- und Medienwissenschaft (IfKMW) entstanden ist, zeichnet auf einer ersten Ebene die organisatorische Entwicklung des ...
Mike Meißner
doaj   +1 more source

Invasive Growth of Ailanthus altissima Trees is Associated with a High Rate of Sensitization in Atopic Patients

Journal of Asthma and Allergy, 2022
Freerk Prenzel1,2 *, Regina Treudler1,3 *, Tobias Lipek,1,2 Maike vom Hove,1,2 Paula Kage,1,3 Simone Kuhs,1,4 Thorsten Kaiser,1,4 Maximilian Bastl,5 Jan Bumberger,6– 8 Jon Genuneit,9,10 Thomas Hornick,8,11 Stefan Klotz,8,12 Julia Zarnowski,1,3 ...
Prenzel F, Treudler R, Lipek T, vom Hove M, Kage P, Kuhs S, Kaiser T, Bastl M, Bumberger J, Genuneit J, Hornick T, Klotz S, Zarnowski J, Boege M, Zebralla V, Simon JC, Dunker S   +16 more
doaj  

Adipocyte Myoglobin Is a Determinant of Energy Expenditure and a Potential Target to Limit Obesity

Advanced Science, EarlyView.
Myoglobin, known as a muscle oxygen‐carrying protein, is shown to play a key role in fat cells that burn energy. Loss of myoglobin reduces the body's ability to generate heat and increases obesity risk, while restoring it improves metabolism. The study identifies myoglobin as a regulator of fat burning and a potential target to enhance energy ...
Christian Strehlau, Helen Broghammer, Claudia Gebhardt, Anne Hoffmann, Tobias Hagemann, Şeyma Midilli, Rachel S. Zimmer, Kristin Schubert, Vasiliki Karagiannakou, Anastasia Georgiadi, Mario Ost, Martin Krüger, Lisa Roth, Kerstin Krause, Nora Klöting, Maria Keller, Martin Wabitsch, Rima Nuwayhid, Roland H. Stimson, Michael Stumvoll, Matthias Blüher, Juliane Weiner, John T. Heiker   +22 more
wiley   +1 more source

“Importing” the Enlightenment and “Enlightenment at the margins”. The example of Bohemia as a language and religious frontier, 1770-1800

Cornova
This contribution explores the hypothesis that 18th-century Bohemia, which was effectively a political and informational periphery directed from Vienna, also functioned – thanks to its geographical position and other factors and despite unfavourable ...
Daniela Tinková
doaj   +1 more source