Results 101 to 110 of about 129,759 (292)

All-Trans Retinoic Acid Promotes an M1- to M2-Phenotype Shift and Inhibits Macrophage-Mediated Immunity to Leishmania major

open access: yesFrontiers in Immunology, 2017
As key cells, able to host and kill Leishmania parasites, inflammatory monocytes/macrophages are potential vaccine and therapeutic targets to improve immune responses in Leishmaniasis.
N. S. Vellozo   +7 more
semanticscholar   +1 more source

Developing giant plasma membrane vesicles from Leishmania cells to investigate the role of membrane proteins in photodynamic inactivation

open access: yesPhotochemistry and Photobiology, EarlyView.
In this study, we developed giant plasma membrane vesicles (GPMVs) from Leishmania amazonensis promastigote membranes to investigate the role of protein‐embedded membranes in methylene blue (MB) photooxidation. Upon MB photoactivation in model lipid membranes (giant unilamellar vesicles, GUVs), a distinct photooxidation effect was observed, marked by ...
Maressa D. F. de Souza   +3 more
wiley   +1 more source

Spatial distribution, Leishmania species and clinical traits of Cutaneous Leishmaniasis cases in the Colombian army

open access: yesPLoS Neglected Tropical Diseases, 2017
In Colombia, the cutaneous leishmaniasis (CL) is the most common manifestation across the army personnel. Hence, it is mandatory to determine the species associated with the disease as well as the association with the clinical traits.
L. H. Patino   +8 more
semanticscholar   +1 more source

Assessment of Leishmania exposure in blood donors from a non‐endemic urban area: A study in São Paulo

open access: yesVox Sanguinis, EarlyView.
Abstract Background and Objectives According to the World Health Organization, more than 1 billion people are at risk of leishmaniasis in over 89 countries. Environmental changes such as deforestation, urban expansion and climate change facilitate the spread of sand fly vectors and reservoirs, increasing disease transmission.
Ismael Severino de Lima   +14 more
wiley   +1 more source

Species structure of sand fly (Diptera: Psychodidae) fauna in the Brazilian western Amazon

open access: yesMemorias do Instituto Oswaldo Cruz, 2009
We surveyed areas of the state of Rondônia in western Amazon for phlebotomine, which are potential vectors of leishmaniasis. A total of 5,998 specimens were captured, resulting in the identification of 48 species within the Lutzomyia (99.98%) and ...
Luiz Herman Soares Gil   +10 more
doaj   +1 more source

Canine leishmaniosis caused by Leishmania major and Leishmania tropica: comparative findings and serology

open access: yesParasites & Vectors, 2017
BackgroundInfection and clinical disease associated with Leishmania major and Leishmania tropica, two common agents of human cutaneous leishmaniosis, have rarely been reported in dogs.
G. Baneth   +3 more
semanticscholar   +1 more source

Bidirectional Interaction Between Liposomal Amphotericin B Pharmacokinetics and Parasite Dynamics in Patients With Post‐Kala‐Azar Dermal Leishmaniasis: Potential Implications for Optimal Dosing

open access: yesClinical Pharmacology &Therapeutics, Volume 119, Issue 2, Page 437-446, February 2026.
Post‐kala‐azar dermal leishmaniasis (PKDL) involves a high macrophage burden in which the Leishmania parasites reside. Liposomal amphotericin B (LAmB) plays a key role in the treatment of PKDL. The mononuclear phagocyte system (MPS) is crucial in the distribution of liposomal drugs as well as the leishmaniasis pathophysiology.
Wan‐Yu Chu   +12 more
wiley   +1 more source

Investigation of Antiparasitic Effect of Juniperus communis L. Fruits Extracts

open access: yesTürkiye Parazitoloji Dergisi
Objective: Juniperus communis (J. communis) (common juniper) is a plant that has been used for medicinal purposes for centuries. This study aims to evaluate the antiparasitic effects of ethanol, methanol, chloroform, and water extracts of J.
İbrahim Çavuş   +5 more
doaj   +1 more source

Arginase activity in pathogenic and non-pathogenic species of Leishmania parasites

open access: yesPLoS Neglected Tropical Diseases, 2017
Proliferation of Leishmania (L.) parasites depends on polyamine availability, which can be generated by the L-arginine catabolism and the enzymatic activity of arginase (ARG) of the parasites and of the mammalian hosts.
A. Badirzadeh   +8 more
semanticscholar   +1 more source

Modulation of succinyl‐CoA:3‐ketoacid CoA transferase activity by a single amino acid residue in acetate:succinate CoA transferase from Trypanosoma brucei, the causative agent of African sleeping sickness

open access: yesProtein Science, Volume 35, Issue 2, February 2026.
Abstract Trypanosomatids are protozoan parasites that remain a global health challenge due to the limited efficacy, safety, and durability of current treatments. Acetate: succinate CoA transferase (ASCT), together with succinyl‐CoA synthase (SCS), forms the ASCT/SCS cycle that fuels ATP production and generates acetate, a central metabolic intermediate
Kota Mochizuki   +13 more
wiley   +1 more source

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