Results 111 to 120 of about 169,942 (293)

Cure of murine leishmaniasis with anti-interleukin 4 monoclonal antibody. Evidence for a T cell-dependent, interferon gamma-independent mechanism. [PDF]

, 1990
BALB/c mice infected with Leishmania major develop fatal, progressive disease, despite an immune response characterized by expansion of CD4+ T cells in the draining lymph nodes.
Dawkins, RS, Heinzel, FP, Holaday, BJ, Locksley, RM, Pu, RT, Sadick, MD   +5 more
core   +1 more source

Posttranslational modifications of heterologous proteins expressed in Nicotiana benthamiana

Plant Biotechnology Journal, EarlyView.
Summary The success of Nicotiana benthamiana as a workhorse for heterologous protein production is closely linked to its accessibility and tolerance to genetic manipulation, allowing efficient engineering of posttranslational protein modifications (PTMs) that are critical for the function and stability of heterologous proteins.
Kathrin Göritzer, Somanath Kallolimath, Richard Strasser   +2 more
wiley   +1 more source

Targeting Aurora Kinases as Essential Cell‐Cycle Regulators to Deliver Multi‐Stage Antimalarials Against Plasmodium Falciparum

Angewandte Chemie, Volume 137, Issue 51, December 15, 2025.
In this study, we repurposed human Aurora kinase‐specific inhibitors to identify potential antimalarial agents. Two inhibitors, hesperadin and TAE684, exhibited sub‐micromolar activity across multiple parasite stages, with hesperadin demonstrating significant potency and selectivity by specifically targeting PfArk1.
Henrico Langeveld, Keletso Maepa, Marché Maree, Jessica L. Thibaud, Nicolaas Salomane, Rosie Bridgwater, Mufuliat T. Famodimu, Luiz C. Godoy, Charisse Flerida A. Pasaje, Nonlawat Boonyalai, Mariana Laureano de Souza, Justin Fong, Tayla Rabie, Mariëtte van der Watt, Rensu P. Theart, Sonja Ghidelli‐Disse, Jacquin C. Niles, Marcus C. S. Lee, Elizabeth A. Winzeler, Michael J. Delves, Kelly Chibale, Kathryn J. Wicht, Lauren B. Coulson, Lyn‐Marié Birkholtz   +23 more
wiley   +2 more sources

Investigation of Antiparasitic Effect of Juniperus communis L. Fruits Extracts

Türkiye Parazitoloji Dergisi
Objective: Juniperus communis (J. communis) (common juniper) is a plant that has been used for medicinal purposes for centuries. This study aims to evaluate the antiparasitic effects of ethanol, methanol, chloroform, and water extracts of J.
İbrahim Çavuş, Yener Özel, Varol Tunalı, Hüsniye Kayalar, Kor Yereli, Ahmet Özbilgin   +5 more
doaj   +1 more source

Developing giant plasma membrane vesicles from Leishmania cells to investigate the role of membrane proteins in photodynamic inactivation

Photochemistry and Photobiology, EarlyView.
In this study, we developed giant plasma membrane vesicles (GPMVs) from Leishmania amazonensis promastigote membranes to investigate the role of protein‐embedded membranes in methylene blue (MB) photooxidation. Upon MB photoactivation in model lipid membranes (giant unilamellar vesicles, GUVs), a distinct photooxidation effect was observed, marked by ...
Maressa D. F. de Souza, Pietro Ciancaglini, Rosangela Itri, Martha S. Ribeiro   +3 more
wiley   +1 more source

Management of Canine Leishmaniasis and the Treatment Trends of Veterinarians in Aegean Region of Türkiye: A Questionnaire-based Survey

Türkiye Parazitoloji Dergisi
Objective: Canine leishmaniasis (CanL) is an important veterinary and public health problem in Mediterranean countries. Although CanL and vector sandflies are widespread in the study area, there are no standardized diagnostic and treatment methods ...
Metin Pekağırbaş, Mehmet Karakuş, Elif Dönmez, Hüseyin Gökhan Özdemir, Yusuf Özbel, Seray Töz   +5 more
doaj   +1 more source

Manifestaciones tóxicas cardiovasculares con el uso de antimoniales en una paciente con leishmaniasis cutánea

Medicina U.P.B., 2019
La toxicidad por antimoniales tiene múltiples manifestaciones sistémicas, entre ellas, las alteraciones cardiovasculares son de las de mayor gravedad, que pueden, incluso, llevar a la muerte.
Adrián Valverde Legarda
doaj   +1 more source

Comparative genomic analysis of Leishmania (Viannia) peruviana and Leishmania (Viannia) braziliensis [PDF]

, 2015
Hugo O. Valdivia, João Luís Reis-Cunha, Gabriela F Rodrigues-Luiz, Rodrigo P. Baptista, G. Christian Baldeviano, Vincent R. Gerbasi, Deborah E. Dobson, Francine Pratlong, Patrick Bastien, Andrés G. Lescano, Stephen M. Beverley, Daniella Castanheira Bartholomeu   +11 more
openalex   +1 more source

Artificial Intelligence in Veterinary Clinical Pathology—An Introduction and Review

Veterinary Clinical Pathology, EarlyView.
ABSTRACT Artificial intelligence (AI), particularly through machine learning and deep learning, presents opportunities for the enhancement of the workflow of the veterinary clinical pathologist. This review introduces basic concepts in AI in a nontechnical manner and explores the qualification and integration of AI in veterinary clinical pathology. The
Samuel V. Neal, Daniel G. Rudmann, Kara N. Corps   +2 more
wiley   +1 more source

Sialic Acid and Colchicine Functionalized Silica Nanoparticles: A Novel Approach to Leishmanicidal Selective Treatments

Biomedicines
Background/Objectives: Leishmaniasis remains a neglected tropical disease, with nearly one million new cases annually and limited investment in research.
Adan Jesus Galue-Parra, Sandra Jimenez-Falcao, Esther Arribas-Yuste, Clotilde Marin, Jose Manuel Mendez-Arriaga   +4 more
doaj   +1 more source