Results 111 to 120 of about 152,189 (278)

Intralesional gene expression profile of JAK-STAT signaling pathway and associated cytokines in Leishmania tropica-infected patients

Frontiers in Immunology
BackgroundThe JAK-STAT signaling pathway is a central cascade of signal transduction for the myriad of cytokines in which dysregulation has been implicated in progression of inflammatory and infectious diseases.
Shima Hadifar, Nasrin Masoudzadeh, Hossein Heydari, Vahid Mashayekhi Goyonlo, Mohammadali Kerachian, Maryam Daneshpazhooh, Ali Sadeghnia, Nasim Tootoonchi, Reza Erfanian Salim, Sima Rafati, Ali M. Harandi   +10 more
doaj   +1 more source

Systematics, diagnosis and treatment of wound infections in chronic wounds: A position paper from WundDACH

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Summary Wound infections are still an interdisciplinary and interprofessional challenge, because of numerous complications, particularly in people with chronic wounds. There are many different concepts and approaches in this field today. Therefore, WundDACH, the umbrella organization of the German‐speaking wound healing societies, wrote a position ...
Joachim Dissemond, Julian‐Dario Rembe, Bernd Assenheimer, Marjam Barysch‐Bonderer, Veronika Gerber, Jan Kottner, Peter Kurz, Martin Motzkus, Eva‐Maria Panfil, Sebastian Probst, Robert Strohal, Jürg Traber, Andreas Schwarzkopf   +12 more
wiley   +1 more source

The TLR2/6 ligand PAM2CSK4 is a Th2 polarizing adjuvant in Leishmania major and Brugia malayi murine vaccine models. [PDF]

, 2016
Toll-like receptors (TLRs) play an important role in the innate and adaptive immune responses to pathogens, and are the target of new vaccine adjuvants.
Bates, PA, Guimarães, A, Halliday, A, Taylor, MJ, Turner, JD   +4 more
core   +6 more sources

Integrated analysis of lncRNA and mRNA expression profiles in cutaneous leishmaniasis lesions caused by Leishmania tropica

Frontiers in Cellular and Infection Microbiology
BackgroundCutaneous leishmaniasis (CL), caused by Leishmania (L.) species, remains a neglected tropical disease in many developing countries. We and others have shown that different Leishmania species can alter the gene expression profile of human host ...
Shima Hadifar, Nasrin Masoudzadeh, Björn Andersson, Hossein Heydari, Vahid Mashayekhi Goyonlo, Mohammadali Kerachian, Josefine Persson, Hasan Rahimi-Tamandegani, Reza Erfanian Salim, Sima Rafati, Ali M. Harandi   +10 more
doaj   +1 more source

New insights into Sti1/Hop's cochaperone function highlight the complexity of proteostatic regulation

The FEBS Journal, EarlyView.
Sti1/Hop functions extend beyond scaffolding in the Hsp70‐Hsp90 chaperone complex to sequester misfolded proteins during cell stress. Consequently, imbalances between levels of Sti1/Hop relative to the rest of the proteostasis machinery negatively affect fitness and stress resilience. Sti1/Hop is a cochaperone that regulates Hsp70 and Hsp90 chaperones.
Gregory Lloyd Blatch, Adrienne Lesley Edkins   +1 more
wiley   +1 more source

Rapid Detection of Leishmania infantum Infection in Dogs: Comparative Study Using an Immunochromatographic Dipstick Test, Enzyme-Linked Immunosorbent Assay, and PCR [PDF]

, 2002
Current zoonotic visceral leishmaniasis (ZVL) control programs in Brazil include the culling of Leishmania infantum-infected reservoir dogs, a strategy that has failed to prevent a rise of canine and human ZVL cases over the past decade.
Bruce Alex, Bruce Alex, Clive R. Davies, Clive R. Davies, J. Clin Microbiol, Richard Reithinger, Richard Reithinger, Rupert J. Quinnell, Rupert J. Quinnell   +8 more
core   +3 more sources

Leishmanicidal Activity of Aliphatic and Aromatic Lactones: Correlation Structure-Activity

Molecules, 2009
Several aliphatic and aromatic lactones and two dimers were synthesized using the sequence: allylation - esterification - metathesis. These compounds were active in vitro against intracellular amastigotes of Leishmania panamensis.
Fernando Echeverri, Wilson Cardona, Sara Robledo, Winston Quiñones, Marcela Castaño   +4 more
doaj   +1 more source

Coagulation status of immune‐mediated polyarthritis in dogs

Journal of Small Animal Practice, EarlyView.
Objective To describe the coagulation status of dogs with immune‐mediated polyarthritis. Materials and Methods Hospital records at a single referral centre were retrospectively reviewed for dogs diagnosed with immune‐mediated polyarthritis. Cases were classified as hypercoagulable, normocoagulable, hypocoagulable, or hypercoagulable and hypocoagulable ...
L. A. F. Packham, V. Black
wiley   +1 more source

Characterization of oxidative stress in Leishmaniasis-infected or LPS-stimulated macrophages using electrochemical impedance spectroscopy [PDF]

, 2010
The physiological changes caused by external stimuli can be employed as parameters to study pathogen infection in cells and the effect of drugs. Among analytical methods, impedance is potentially useful to give insight into cellular behavior by studying ...
Coste, Agnès, Fabre, Paul-Louis, Launay, Jérôme, Nepveu, Françoise, Reybier, Karine, Ribaut, Clothilde   +5 more
core   +2 more sources

Steroid‐responsive generalised sterile necrotising pyogranulomatous lymphadenitis in a cat

Journal of Small Animal Practice, EarlyView.
A 1.5‐year‐old neutered male cat was presented with fever, inappetence, lethargy and marked generalised lymphadenopathy of 4 days duration. Excisional biopsy of peripheral lymph nodes revealed necrotising pyogranulomatous lymphadenitis. Extensive investigation failed to identify an underlying infectious [bacterial (Bartonella, Mycobacteria, Mycoplasma,
L. Lecot, E. Ramery, M. Hugonnard, A. Tortereau, É. Krafft   +4 more
wiley   +1 more source