Results 181 to 190 of about 6,508 (210)

Familial Aggregation of Leishmania chagasi Infection in Northeastern Brazil

The American Journal of Tropical Medicine and Hygiene, 1995
A sample of 1,604 individuals belonging to 243 nuclear families from an endemic area of visceral leishmaniasis (Jacobina, Bahia State, Brazil) was studied to disclose the intrafamilial pattern of infection. Significant father to offspring, mother to offspring, and sibling to sibling associations, in contrast a with nonsignificant father to mother ...
P H, Cabello, A M, Lima, E S, Azevedo, H, Krieger   +3 more
openaire   +2 more sources

Biosynthesis of the major surface protease GP63 of Leishmania chagasi

Molecular and Biochemical Parasitology, 2002
The protozoan Leishmania chagasi expresses a surface metalloprotease, GP63, whose abundance increases 14-fold as parasites grow from logarithmic to stationary phase. L. chagasi GP63 is encoded by three classes of MSP genes that are differentially expressed during parasite growth. Using metabolic labeling and immunoprecipitation, we found L.
Chaoqun, Yao, Kevin G, Leidal, Andrew, Brittingham, Deirdre E, Tarr, John E, Donelson, Mary E, Wilson   +5 more
openaire   +2 more sources

Association of Nutritional Status with the Response to Infection with Leishmania chagasi

The American Journal of Tropical Medicine and Hygiene, 2008
Outcomes of infection with Leishmania chagasi range from self-resolving infection to visceral leishmaniasis (VL). Risk factors determining development of disease are not totally understood, but probably include environmental influences and host genetics. We assessed whether nutrition influenced the outcome of Leishmania infection by comparing relatives
Bruna L Lima, Maciel, Hênio G, Lacerda, José W, Queiroz, Juliana, Galvão, Núbia N, Pontes, Roberto, Dimenstein, Stephen E, McGowan, Lúcia F C, Pedrosa, Selma M B, Jerônimo   +8 more
openaire   +2 more sources

Cleavable complex formation in Leishmania chagasi treated with anilinoacridines

Molecular and Biochemical Parasitology, 1994
Anilinoacridines have recently been found to possess antiparasitic activity toward Leishmania, Trypanosoma, and Plasmodium species. These compounds have been examined for their ability to generate cleavable complex, the protein-associated DNA lesion characteristic of topoisomerase II involvement, in intact L. chagasi promastigotes.
K A, Werbovetz, P G, Spoors, R D, Pearson, T L, Macdonald   +3 more
openaire   +2 more sources

Correlates of Leishmania-Specific Immunity in the Clinical Spectrum of Infection withLeishmania chagasi

Journal of Infectious Diseases, 1993
Patients from across the spectrum of clinical manifestations of Leishmania chagasi infection were evaluated for in vitro correlates of immunity. Peripheral blood mononuclear cells were assayed for parasite-specific lymphoproliferation, cytokine generation, and the capacity to activate autologous macrophages to kill intracellular amastigotes.
Bettie J. Holaday, Margarida Maria de Lima Pompeu, Thomas Evans, Deborah Nunes de Melo Braga, Maria Jania Texeira, Anastacio de Queiroz Sousa, Michael D. Sadick, Antonio Wilson Vasconcelos, John S. Abrams, Richard D. Pearson, Richard M. Locksley   +10 more
openaire   +2 more sources

Identification of Leishmania chagasi Antigens Recognized by Human Lymphocytes

Journal of Infectious Diseases, 1995
Preparative SDS-PAGE followed by electroelution was used to separate proteins of Leishmania chagasi promastigotes into 67 fractions. These fractions were tested for the ability to stimulate proliferation of peripheral blood mononuclear cells from healthy immune donors who were treated previously for visceral leishmaniasis and from nonimmune controls ...
S M, Jeronimo, E, Higgs, T, Vedvick, B J, Mann, J, Jernigan, W A, Petri, R D, Pearson   +6 more
openaire   +2 more sources

Diffuse Intralobular Liver Fibrosis in Dogs Naturally Infected with Leishmania (Leishmania) chagasi

The American Journal of Tropical Medicine and Hygiene, 2008
The aim of this study was to evaluate the diffuse intralobular fibrosis in dogs naturally infected with Leishmania (Leishmania) chagasi. One hundred five infected animals with positive serologic tests for Leishmania were divided into two clinical groups: 69 symptomatic animals and 36 asymptomatic.
Ferdinan, Melo, Marina, Amaral, Patricia, Oliveira, Wanderson, Lima, Marina, Andrade, Marilene, Michalick, Pedro, Raso, Washington, Tafuri, Wagner, Tafuri   +8 more
openaire   +2 more sources

The Strange Case of Leishmania chagasi

Parasitology Today, 2000
I L, Maurício, J R, Stothard, M A, Miles   +2 more
openaire   +2 more sources

American visceral leishmaniasis: on the origin of Leishmania (Leishmania) chagasi

Transactions of the Royal Society of Tropical Medicine and Hygiene, 1987
R, Lainson, J J, Shaw, F T, Silveira, R R, Braga   +3 more
openaire   +2 more sources

Possible origins ofLeishmania chagasi

Annals of Tropical Medicine & Parasitology, 1980
R, Killick-Kendrick, D H, Molyneux, J A, Rioux, G, Lanotte, A J, Leaney   +4 more
openaire   +2 more sources