Results 1 to 10 of about 2,326 (123)

First molecular detection of Leishmania (Leishmania) infantum chagasi in a domestic cat (Felis catus) from an urban area in eastern Amazon [PDF]

Journal of Venomous Animals and Toxins including Tropical Diseases, 2023
Background: Domestic cats have been implicated as accidental hosts of Leishmania sp. However, in recent years, the recurrent description of new cases in endemic and nonendemic areas draw attention to the potential epidemiological role of cats as ...
Délia Cristina Figueira Aguiar, Daniela de Nazaré dos Santos Nascimento, Dinaiara Fragoso Penner, Brena do Socorro Lima de Castro, Rodrigo Rodrigues Virgolino, Alan Marcel Pamplona Neves, Andrei dos Santos Siqueira, Evonnildo Costa Gonçalves   +7 more
doaj   +2 more sources

Recombinant LPG3 Protein From Leishmania chagasi as an Antigen for the Diagnosis of Canine Visceral Leishmaniasis. [PDF]

Trop Med Int Health
ABSTRACT Visceral leishmaniasis (VL) is a human neglected tropical disease in which dogs participate as reservoirs of the etiological agent Leishmania chagasi. The identification of infected dogs is important to the control of VL, and recombinant proteins are strong antigen candidates for canine visceral leishmaniasis (CVL) serodiagnosis. In this work,
Martins TVF, de Souza ACA, Miranda BM, de Souza RF, Bastos DSS, Ferreira NJS, de Oliveira Mendes TA, da Silva Freitas de Souza C, Machado-Coelho GLL, Bahia MT, de Oliveira LL, Fietto JLR, de Almeida Marques-da-Silva E.   +12 more
europepmc   +2 more sources

Brain Involvement in Leishmaniasis. [PDF]

Cell Biochem Funct
ABSTRACT Leishmaniasis is a neglected tropical disease caused by infection with the protozoan parasite Leishmania and it is a significant global health problem. The disease has a wide clinical spectrum, from tegumentary leishmaniasis (TL) that encompasses cutaneous (CL), mucosal (ML) and cutaneous‐diffuse (CDL) forms, to the potentially fatal systemic ...
Freitas CS, Coelho EAF, Christodoulides M.   +2 more
europepmc   +2 more sources

Thymus and Leishmania at the Crossroads: Autoimmunity and Cancer. [PDF]

Immunology
Conceptual ‘Crossroads Model’ linking Leishmania, thymic infection and immune dysregulation: an integrative model is proposed in which Leishmania infection disrupts thymic architecture and stromal–thymocyte interactions. These alterations converge to promote defective tolerance, increased autoimmune risk and a microenvironment permissive to malignant ...
Barros ABB, Leite GA, de Andrade AG, Reis MDDS, Cavalcante-Silva LHA, Lins MP.   +5 more
europepmc   +2 more sources

Leishmaniasis Transmission Risk at the Forest-Peridomestic Interface in an Area of Southern Sinaloa, Mexico: Entomological, Molecular, and Climatic Evidence. [PDF]

J Parasitol Res
Leishmaniasis, caused by Leishmania spp. and transmitted by phlebotomine sand flies, affects almost 1,000,000 people annually across more than 90 countries. In Mexico, growing evidence of locally acquired transmission in northwestern states makes ecoepidemiological work increasingly urgent.
Tostado JJR, Ureta HC, Avendaño JIT, Moreno JMZ, Higareda CER, Guevara LIP, Medina AIA, Montoya EHT.   +7 more
europepmc   +2 more sources

Peptides as a Therapeutic Alternative Against Leishmaniasis: A Scoping Review. [PDF]

Chem Biol Drug Des
This scoping review of 79 studies identified 231 antimicrobial peptides with anti‐Leishmania activity, including natural‐derived and synthetic peptides (inspired by natural sources or developed through rational design). Most were evaluated in vitro against promastigote and/or amastigote forms, with synthetic peptides showing a more promising effect ...
da Veiga Oliveira ME, Dyminski Parente Ribeiro E, Guenther OHP, Tomiotto-Pellissier F.   +3 more
europepmc   +2 more sources

Assessment of Leishmania exposure in blood donors from a non-endemic urban area: A study in São Paulo. [PDF]

Vox Sang
Abstract Background and Objectives According to the World Health Organization, more than 1 billion people are at risk of leishmaniasis in over 89 countries. Environmental changes such as deforestation, urban expansion and climate change facilitate the spread of sand fly vectors and reservoirs, increasing disease transmission.
de Lima IS, Ferreira SC, Nishiya AS, Kesper N, Ferreira JE, de Castro Gomes CM, Derriga J, Dantas KC, Polato SPG, Salles NA, Lindoso JAL, Fanciani T, de Almeida-Neto C, Rocha V, Mendrone A.   +14 more
europepmc   +2 more sources

Immucillins Impair Leishmania (L.) infantum chagasi and Leishmania (L.) amazonensis Multiplication In Vitro [PDF]

PLoS ONE, 2015
Chemotherapy against visceral leishmaniasis is associated with high toxicity and drug resistance. Leishmania parasites are purine auxotrophs that obtain their purines from exogenous sources.
Peter C Tyler, Keith Clinch, Dirlei Nico
exaly   +2 more sources

Evaluation of the Cutaneous Immunological Milieu Before and After Treatment With Meglumine Antimoniate in Dogs Naturally Affected by Leishmaniosis due to Leishmania infantum. [PDF]

Vet Dermatol
Background: Canine leishmaniosis (CanL) is a zoonotic disease of variable severity. The typical immune response is driven by an exaggerated humoral immune response. Protective immunity is mediated by pro‐inflammatory cytokines that enhance macrophage leishmanicidal activity. Objective: To evaluate the cutaneous and the systemic immune responses as well
Platenik M, Di Loria A, Archer L, Saridomichelakis M, Benvenuto AS, Santoro D.   +5 more
europepmc   +2 more sources

Cortisol Regulates PD-1 and IL-12 in Canine Leishmaniasis. [PDF]

Parasite Immunol
ABSTRACT Canine visceral leishmaniasis (CanL) is a tropical zoonosis caused by Brazil's protozoan Leishmania (L.) infantum. Disorders in the hypothalamic–pituitary–adrenal (HPA) axis have been reported in human and experimental visceral leishmaniasis, but not yet in canine leishmaniasis.
Ito LTS, Umino GM, Guimarães MA, de Souza BMM, Soares SF, Pereira LEAL, de Lima VMF.   +6 more
europepmc   +2 more sources