Results 1 to 10 of about 2,305 (117)

First molecular detection of Leishmania (Leishmania) infantum chagasi in a domestic cat (Felis catus) from an urban area in eastern Amazon [PDF]

Journal of Venomous Animals and Toxins including Tropical Diseases, 2023
Background: Domestic cats have been implicated as accidental hosts of Leishmania sp. However, in recent years, the recurrent description of new cases in endemic and nonendemic areas draw attention to the potential epidemiological role of cats as ...
Délia Cristina Figueira Aguiar, Daniela de Nazaré dos Santos Nascimento, Dinaiara Fragoso Penner, Brena do Socorro Lima de Castro, Rodrigo Rodrigues Virgolino, Alan Marcel Pamplona Neves, Andrei dos Santos Siqueira, Evonnildo Costa Gonçalves   +7 more
doaj   +2 more sources

Visceral leishmaniasis with cutaneous involvement caused by Leishmania infantum-chagasi [PDF]

IDCases, 2018
We report the case of a 66 year-old woman who presented nodular skin lesions on her back and upper extremities. Biopsy revealed amastigotes that were identified as Leishmania infantum-chagasi by PCR.
Mohammed Raja, Jose Armando Gonzales Zamora   +1 more
doaj   +2 more sources

Brain Involvement in Leishmaniasis. [PDF]

Cell Biochem Funct
ABSTRACT Leishmaniasis is a neglected tropical disease caused by infection with the protozoan parasite Leishmania and it is a significant global health problem. The disease has a wide clinical spectrum, from tegumentary leishmaniasis (TL) that encompasses cutaneous (CL), mucosal (ML) and cutaneous‐diffuse (CDL) forms, to the potentially fatal systemic ...
Freitas CS, Coelho EAF, Christodoulides M.   +2 more
europepmc   +2 more sources

Lipophosphoglycan 3 From Binds Heparin With Micromolar Affinity [PDF]

Bioinformatics and Biology Insights, 2018
Leishmania infantum chagasi is an intracellular protozoan parasite responsible for visceral leishmaniasis, a fatal disease in humans. Heparin-binding proteins (HBPs) are proteins that bind to carbohydrates present in glycoproteins or glycolipids ...
Thaís Viana Fialho Martins, Ana Eliza Zeraik, Natália Oliveira Alves, Leandro Licursi de Oliveira, Tiago Antônio de Oliveira Mendes, Ricardo DeMarco, Eduardo de Almeida Marques-da-Silva   +6 more
doaj   +2 more sources

FIRST REPORT OF CUTANEOUS LEISHMANIASIS CAUSED BY Leishmania (Leishmania) infantum chagasi IN AN URBAN AREA OF RIO DE JANEIRO, BRAZIL [PDF]

Revista do Instituto de Medicina Tropical de São Paulo, 2015
SUMMARY American tegumentary leishmaniasis (ATL) is an infectious disease caused by protozoa of the genus Leishmania, and transmitted by sandflies. In the state of Rio de Janeiro, almost all of the cases of American tegumentary leishmaniasis (ATL) are ...
Marcelo Rosandiski LYRA, Maria Inês Fernandes PIMENTEL, Maria de Fátima MADEIRA, Liliane de Fátima ANTONIO, Janine Pontes de Miranda LYRA, Aline FAGUNDES, Armando de Oliveira SCHUBACH   +6 more
doaj   +2 more sources

Assessment of Leishmania exposure in blood donors from a non-endemic urban area: A study in São Paulo. [PDF]

Vox Sang
Abstract Background and Objectives According to the World Health Organization, more than 1 billion people are at risk of leishmaniasis in over 89 countries. Environmental changes such as deforestation, urban expansion and climate change facilitate the spread of sand fly vectors and reservoirs, increasing disease transmission.
de Lima IS, Ferreira SC, Nishiya AS, Kesper N, Ferreira JE, de Castro Gomes CM, Derriga J, Dantas KC, Polato SPG, Salles NA, Lindoso JAL, Fanciani T, de Almeida-Neto C, Rocha V, Mendrone A.   +14 more
europepmc   +2 more sources

Thymus and Leishmania at the Crossroads: Autoimmunity and Cancer. [PDF]

Immunology
Conceptual ‘Crossroads Model’ linking Leishmania, thymic infection and immune dysregulation: an integrative model is proposed in which Leishmania infection disrupts thymic architecture and stromal–thymocyte interactions. These alterations converge to promote defective tolerance, increased autoimmune risk and a microenvironment permissive to malignant ...
Barros ABB, Leite GA, de Andrade AG, Reis MDDS, Cavalcante-Silva LHA, Lins MP.   +5 more
europepmc   +2 more sources

Peptides as a Therapeutic Alternative Against Leishmaniasis: A Scoping Review. [PDF]

Chem Biol Drug Des
This scoping review of 79 studies identified 231 antimicrobial peptides with anti‐Leishmania activity, including natural‐derived and synthetic peptides (inspired by natural sources or developed through rational design). Most were evaluated in vitro against promastigote and/or amastigote forms, with synthetic peptides showing a more promising effect ...
da Veiga Oliveira ME, Dyminski Parente Ribeiro E, Guenther OHP, Tomiotto-Pellissier F.   +3 more
europepmc   +2 more sources

Immucillins Impair Leishmania (L.) infantum chagasi and Leishmania (L.) amazonensis Multiplication In Vitro [PDF]

PLoS ONE, 2015
Chemotherapy against visceral leishmaniasis is associated with high toxicity and drug resistance. Leishmania parasites are purine auxotrophs that obtain their purines from exogenous sources.
Rong Guan, JOSÉ Roberto Meyer-Fernandes, Keith Clinch   +2 more
exaly   +2 more sources

Leishmaniasis Transmission Risk at the Forest-Peridomestic Interface in an Area of Southern Sinaloa, Mexico: Entomological, Molecular, and Climatic Evidence. [PDF]

J Parasitol Res
Leishmaniasis, caused by Leishmania spp. and transmitted by phlebotomine sand flies, affects almost 1,000,000 people annually across more than 90 countries. In Mexico, growing evidence of locally acquired transmission in northwestern states makes ecoepidemiological work increasingly urgent.
Tostado JJR, Ureta HC, Avendaño JIT, Moreno JMZ, Higareda CER, Guevara LIP, Medina AIA, Montoya EHT.   +7 more
europepmc   +2 more sources