The Antileishmanial Potential of C-3 Functionalized Isobenzofuranones against Leishmania (Leishmania) Infantum Chagasi [PDF]
Molecules, 2015 Leishmaniases are diseases caused by protozoan parasites of the genus Leishmania. Clinically, leishmaniases range from cutaneous to visceral forms, with estimated global incidences of 1.2 and 0.4 million cases per year, respectively. The treatment of these diseases relies on multiple parenteral injections with pentavalent antimonials or amphotericin B.
Juliana Lopes Rangel Fietto +2 more
exaly +6 more sources
A novel A2 allele found in Leishmania (Leishmania) infantum chagasi Novo alelo do gene A2 descrito em Leishmania (Leishmania) infantum chagasi [PDF]
Revista Brasileira de Parasitologia Veterinária, 2011 Visceral leishmaniasis (VL) is a widely spread zoonotic disease. In Brazil the disease is caused by Leishmania (Leishmania) infantum chagasi. Peridomestic sandflies acquire the etiological agent by feeding on blood of infected reservoir animals, such as ...
Trícia Maria Ferreira de Sousa Oliveira +7 more
doaj +8 more sources
The transmission of
Parasites & Vectors, 2012 Background Sandflies are vectors of Leishmania, the causative agent of leishmaniasis in mammalian hosts, including humans. The protozoan parasite is transmitted by the sandfly bite during salivation that occurs at the moment of blood feeding.
Secundino Nagila FC +5 more
doaj +3 more sources
Leishmania (infantum) chagasi in canine urinary sediment [PDF]
Revista Brasileira de Parasitologia Veterinária, 2015 Canine visceral leishmaniasis (CVL) is difficult to diagnosis, mainly due to the presence of asymptomatic animals, the diversity of clinical symptoms and the difficulty in obtaining diagnostic evidence of high sensitivity and specificity.
Ivete Lopes de Mendonça +2 more
doaj +3 more sources
Use of a Recombinant Cysteine Proteinase from Leishmania (Leishmania) infantum chagasi for the Immunotherapy of Canine Visceral Leishmaniasis [PDF]
PLoS Neglected Tropical Diseases, 2014 A recombinant cysteine proteinase from Leishmania (Leishmania) infantum chagasi (rLdccys1) was previously shown to induce protective immune responses against murine and canine visceral leishmaniasis. These findings encouraged us to use rLdccys1 in the immunotherapy of naturally infected dogs from Teresina, Piauí, a region of high incidence of visceral ...
Lucilene S Silva +2 more
exaly +6 more sources
Thymus and Leishmania at the Crossroads: Autoimmunity and Cancer. [PDF]
ImmunologyConceptual ‘Crossroads Model’ linking Leishmania, thymic infection and immune dysregulation: an integrative model is proposed in which Leishmania infection disrupts thymic architecture and stromal–thymocyte interactions. These alterations converge to promote defective tolerance, increased autoimmune risk and a microenvironment permissive to malignant ...
Barros ABB +5 more
europepmc +2 more sources
Leishmaniasis Transmission Risk at the Forest-Peridomestic Interface in an Area of Southern Sinaloa, Mexico: Entomological, Molecular, and Climatic Evidence. [PDF]
J Parasitol ResLeishmaniasis, caused by Leishmania spp. and transmitted by phlebotomine sand flies, affects almost 1,000,000 people annually across more than 90 countries. In Mexico, growing evidence of locally acquired transmission in northwestern states makes ecoepidemiological work increasingly urgent.
Tostado JJR +7 more
europepmc +2 more sources
Revista da Sociedade Brasileira de Medicina Tropical, 2010 INTRODUÇÃO: Leishmaniose visceral é uma zoonose que acomete diversos mamíferos tendo os canídeos domésticos como principais reservatórios em ambiente urbano.
Nely Pinheiro Souza +6 more
doaj +2 more sources
Experimental infection parameters in Galea spixii (Rodentia: Caviidae) with Leishmania infantum chagasi [PDF]
Memorias do Instituto Oswaldo Cruz, 2008 In order to better understand the epidemiological transmission network of leishmaniasis, an endemic disease in Northeast Brazil, we investigated the susceptibility of Spix yellow-toothed cavies (Galea spixii) to the Leishmania infantum chagasi parasite ...
Patrícia Batista Barra Medeiros Barbosa +3 more
doaj +4 more sources
Whole-Genome Sequencing of Leishmania infantum chagasi Isolates from Honduras and Brazil. [PDF]
Microbiol Resour Announc, 2021 This work reports on the whole-genome sequencing of Leishmania infantum chagasi from Honduras (Central America) and Brazil (South America).
Silveira FT +19 more
europepmc +3 more sources