Tools for molecular epidemiology of leishmaniasis [PDF]
Molecular biology provides a range of tools for epidemiological investigations. So far, there has been limited application of molecular epidemiology in leishmaniasis research.
Mauricio, I
core +4 more sources
Attenuation of Leishmania infantum chagasi Metacyclic Promastigotes by Sterol Depletion [PDF]
ABSTRACTThe infectious metacyclic promastigotes ofLeishmaniaprotozoa establish infection in a mammalian host after they are deposited into the dermis by a sand fly vector. SeveralLeishmaniavirulence factors promote infection, including the glycosylphosphatidylinositol membrane-anchored major surface protease (MSP).
Chaoqun, Yao +6 more
openaire +2 more sources
Differentiation and gene flow among European populations of Leishmania infantum MON-1. [PDF]
BACKGROUND: Leishmania infantum is the causative agent of visceral and cutaneous leishmaniasis in the Mediterranean region, South America, and China. MON-1 L.
Schaar, Matthias +44 more
core +2 more sources
A leishmaniose visceral (LV) é uma doença infecciosa crônica frequentemente fatal causada pela Leishmania infantum chagasi nas Américas. A enfermidade pode acometer vários órgãos, determinando diferentes manifestações clínicas.
R.S. Mendes +7 more
doaj +1 more source
Heterogeneity of Leishmania infantum chagasi Kinetoplast DNA in Teresina (Brazil) [PDF]
Leishmania infantum chagasi is the causative agent of visceral leishmaniasis in Brazil. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis of kinetoplast DNA (kDNA) minicircles was used to evaluate genetic profiles of 48 Leishmania infantum chagasi strains from dog and human parasite cultures, fresh collected dog ...
Diego Peres, Alonso +4 more
openaire +2 more sources
A real-time PCR assay to estimate Leishmania chagasi load in its natural sand fly vector Lutzomyia longipalpis [PDF]
Leishmania chagasi, transmitted mainly by Lutzomyia longipalpis sand flies, causes visceral leishmaniasis and atypical cutaneous leishmaniasis in Latin America.
Bates, Paul A. +14 more
core +1 more source
Inhibition of trypsin expression in Lutzomyia longipalpis using RNAi enhances the survival of Leishmania [PDF]
Background Leishmania parasites must overcome several barriers to achieve transmission by their sand fly vectors. One of the earliest threats is exposure to enzymes during blood meal digestion.
Diaz-Albiter, Hector +4 more
core +5 more sources
Biodistribution of meglumine antimoniate in healthy and Leishmania (Leishmania) infantum chagasi-infected BALB/c mice [PDF]
Pentavalent antimonials such as meglumine antimoniate (MA) are the primary treatments for leishmaniasis, a complex disease caused by protozoan parasites of the genus Leishmania . Despite over 70 years of clinical use, their mechanisms of action, toxicity and pharmacokinetics have not been fully elucidated.
Borborema, Samanta Etel Treiger +3 more
openaire +4 more sources
Heterogeneities in leishmania infantum infection : using skin parasite burdens to identify highly infectious dogs [PDF]
Background: The relationships between heterogeneities in host infection and infectiousness (transmission to arthropod vectors) can provide important insights for disease management.
Quinnell, Rupert J. +26 more
core +2 more sources
SUMMARY American tegumentary leishmaniasis (ATL) is an infectious disease caused by protozoa of the genus Leishmania, and transmitted by sandflies. In the state of Rio de Janeiro, almost all of the cases of American tegumentary leishmaniasis (ATL) are ...
Marcelo Rosandiski LYRA +6 more
doaj +1 more source

