Results 51 to 60 of about 2,306 (123)

Antileishmanial activity and immunomodulatory effect of secosubamolide, a butanolide isolated from Nectandra oppositifolia (Lauraceae)

Journal of Venomous Animals and Toxins including Tropical Diseases
Background: Visceral leishmaniasis is a complex neglected tropical disease caused by Leishmania donovani complex. Its current treatment reveals strong limitations, especially high toxicity.
Thais A. da Costa-Silva, Geanne A. Alves Conserva, Andrés J. Galisteo Jr, Andre G. Tempone, João Henrique G. Lago   +4 more
doaj   +1 more source

Therapeutic Effect of Barberry (Berberis vulgaris) Root Extract on Experimental Cutaneous Leishmaniosis in a BALB/c Mouse Model

Veterinary Medicine and Science, Volume 11, Issue 5, September 2025.
Barberry (Berberis vulgaris) root extract shows potential in treating cutaneous leishmaniasis caused by Leishmania major. In a BALB/c mouse model, treatment significantly reduced wound size and parasite load while enhancing inflammatory markers IL‐1 and IL‐6. These results highlight barberry's therapeutic promise against leishmaniasis.
Sadegh Shirian, Morteza Norouzi Cholcheh, Saeed Habibian Dehkordi, Behnam Bakhtiari Moghadam   +3 more
wiley   +1 more source

Visceral leishmaniasis with cutaneous involvement caused by Leishmania infantum-chagasi

IDCases, 2018
We report the case of a 66 year-old woman who presented nodular skin lesions on her back and upper extremities. Biopsy revealed amastigotes that were identified as Leishmania infantum-chagasi by PCR.
Mohammed Raja, Jose Armando Gonzales Zamora   +1 more
doaj   +1 more source

Cross-protective effect of a combined L5 plus L3 Leishmania major ribosomal protein based vaccine combined with a Th1 adjuvant in murine cutaneous and visceral leishmaniasis

Parasites & Vectors, 2014
Background Two Leishmania major ribosomal proteins L3 (LmL3) and L5 (LmL5) have been described as protective molecules against cutaneous leishmaniasis due to infection with L.
Laura Ramirez, Laura Corvo, Mariana C Duarte, Miguel A Chávez-Fumagalli, Diogo G Valadares, Diego M Santos, Camila I de Oliveira, Marta R Escutia, Carlos Alonso, Pedro Bonay, Carlos AP Tavares, Eduardo AF Coelho, Manuel Soto   +12 more
doaj   +1 more source

Vaccination with L. infantum chagasi nucleosomal histones confers protection against new world cutaneous leishmaniasis caused by Leishmania braziliensis.

PLoS ONE, 2012
BackgroundNucleosomal histones are intracellular proteins that are highly conserved among Leishmania species. After parasite destruction or spontaneous lysis, exposure to these proteins elicits a strong host immune response.
Marcia W Carneiro, Diego M Santos, Kiyoshi F Fukutani, Jorge Clarencio, Jose Carlos Miranda, Claudia Brodskyn, Aldina Barral, Manoel Barral-Netto, Manuel Soto, Camila I de Oliveira   +9 more
doaj   +1 more source

Integration of Machine Learning‐QSAR and Polypharmacology in Drug Discovery for Leishmaniasis Using Natural and Repurposed Compounds

ChemistrySelect, Volume 10, Issue 21, June 4, 2025.
Leishmaniasis affects over 1 billion people worldwide, with current treatments limited by toxicity and efficacy. This study used machine learning (ML), QSAR, and polypharmacology to identify potential drug candidates, analyzing 12,072 compounds with random forest and XGBoost models.
Laís Salvador do Amaral, Amiel Artur Morais, Alexandre de Fátima Cobre, Raul Edison Luna Lazo, Dile Pontarolo Stremel, Jaqueline Carneiro, Luana Mota Ferreira, Roberto Pontarolo   +7 more
wiley   +1 more source

New record of preclinical diagnosis of American visceral leishmaniasis in Amazonian Brazil encourages optimizing disease control

Parasite Epidemiology and Control, 2020
The clinical-immunological spectrum of human Leishmania (L.) infantum chagasi-infection in Amazonian Brazil has recently been reviewed based on the combined use of the delayed-type hypersensitivity (DTH) and indirect fluorescence antibody test (IFAT-IgG ...
Luciana Lima, Thiago Vasconcelos-dos-Santos, Marliane Campos, Patrícia Karla Ramos, Claudia Gomes, Marcia Laurenti, Vania da Matta, Carlos Corbett, Fernando Silveira   +8 more
doaj   +1 more source

A Century of Epidemiological Advances in Cutaneous and Visceral Leishmaniasis in Algeria

Journal of Parasitology Research, Volume 2025, Issue 1, 2025.
Leishmaniasis is a group of diseases transmitted by sandflies, affecting humans and animals, with three clinical presentations: cutaneous, mucosal, and visceral. The disease is caused by the parasite Leishmania and is a significant global health issue, with approximately two million cases annually and 350 million people at risk.
Naouel Eddaikra, Razika Benikhlef, Denis Sereno, Satabdi Datta Choudhury   +3 more
wiley   +1 more source

Identification of Leishmania species by high-resolution DNA dissociation in cases of American cutaneous leishmaniasis, [PDF]

Anais Brasileiros de Dermatologia
Background American cutaneous leishmaniasis is an infectious dermatosis caused by protozoa of the genus Leishmania, which comprises a broad spectrum of clinical manifestations depending on the parasite species involved in the infections and the ...
John Verrinder Veasey, Ricardo Andrade Zampieri, Rute Facchini Lellis, Thaís Helena Proença de Freitas, Lucile Maria Floeter Winter   +4 more
doaj   +2 more sources

Performance of Extracellular Vesicles From Leishmania (Leishmania) infantum for Serological Diagnosis of Human and Canine Visceral Leishmaniasis

Journal of Parasitology Research, Volume 2025, Issue 1, 2025.
Visceral leishmaniasis (VL) is a zoonotic disease in which dogs are the main reservoirs. Until now, the serological tests do not present satisfactory sensitivity for diagnosis of these hosts. One of the functions of extracellular vesicles (EVs) is related to immunological host response.
Allecineia Bispo da Cruz, Francieli Marinho Carneiro, Noemi Nosomi Taniwaki, Gislene Mitsue Namiyama, Débora Oliveira dos Santos, Katia Gomes Castellão, Isabelle Martins Ribeiro Ferreira, Roberto Mitsuyoshi Hiramoto, Vera Lucia Pereira-Chioccola, Bernard Marchand   +9 more
wiley   +1 more source