Results 171 to 180 of about 69,891 (211)

Lipophosphoglycan Antigen Shedding By Leishmania Donovani

Journal of Eukaryotic Microbiology, 1993
ABSTRACT. The biochemical characterizations of lipophosphoglycans from various Leishmania species reported by other workers may or may not contain several types of lipophosphoglycan molecules. This is the first report in which a specific lipophosphoglycan has been defined by both its antigenie and electrophoretic properties. Furthermore, a purification
E S, Kaneshiro, M A, Wyder
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Uptake and turnover of glucose in Leishmania donovani

Molecular and Biochemical Parasitology, 1993
Glucose uptake and metabolism by Leishmania donovani promastigotes was studied using D-[14C]glucose in combination with the silicone oil centrifugation technique on organisms preadapted to different growth rates and glucose availability in the chemostat. The uptake step was differentiated from the subsequent metabolism by separation in time rather than
B H, Ter Kuile, F R, Opperdoes
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The activity of hydroxynaphthoquinones against Leishmania donovani

Journal of Antimicrobial Chemotherapy, 1992
The hydroxynaphthoquinones, buparvaquone, 250C80 and 56W82, showed high activity in vitro against Leishmania donovani amastigotes in mouse peritoneal macrophages, with ED50 values of 0.05, 2.95 and 13.82 microM, respectively. Fourteen other hydroxynaphthoquinones were tested, of which only 566C80 and 608C86 showed significant activity against ...
S L, Croft, J, Hogg, W E, Gutteridge, A T, Hudson, A W, Randall   +4 more
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Cloning and Characterization of Leishmania donovani Telomeres

Experimental Parasitology, 2000
We describe here the cloning and sequence characterization of the absolute termini of several telomeres from the human parasite Leishmania donovani using a vector-adapter protocol. The 3' protruding strand of L. donovani telomeres terminates with the sequence 5'-GGTTAGGGT-OH 3'.
M A, Chiurillo, A E, Beck, T, Devos, P J, Myler, K, Stuart, J L, Ramirez   +5 more
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Heme metabolism in promastigotes of Leishmania donovani

Molecular and Cellular Biochemistry, 1997
Promastigotes of Leishmania donovani (Dd-8 strain) showed presence of important key enzymes of heme synthesizing (delta-aminolevulinic acid synthase and ferrochelatase) and degrading (heme oxygenase and biliverdin reductase) systems, classical leishmanicidal drugs viz allopurinol, amphotericin B, pentamidine and CDRI compound 93/202 inhibited the heme ...
P, Srivastava, G D, Sharma, K K, Kamboj, A K, Rastogi, V C, Pandey   +4 more
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Chromosome size polymorphisms of Leishmania donovani

Molecular and Biochemical Parasitology, 1987
A minimum of 22 chromosomes were found in all Leishmania donovani stocks examined by orthogonal field alternation gel electrophoresis (OFAGE). Chromosome sizes ranged from approximately 270 to 4000 kb. Certain chromosomes were polymorphic in size between stocks and chromosomes present in some stocks had no apparent equivalent in others.
R P, Bishop, M A, Miles
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Macromolecular Synthesis in Leishmania donovani Amastigotes

The Journal of Parasitology, 1985
Amastigotes (non-flagellated tissue forms) of Leishmania sp. reside and multiply within the phagolysosomes in tissue macrophages of vertebrate hosts. They are true obligate, intracellular parasites and do not persist as viable entities outside of host cells.
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Secretion of Sucrase by Leishmania donovani

Journal of Eukaryotic Microbiology, 1994
ABSTRACT. Leishmania donovani promastigotes were collected, washed, resuspended in buffer, and assayed for sucrase activity. No activity was observed in the intact washed cells, but activity was measurable when the cells were permeabilized with Triton X‐100.
J J, Blum, F R, Opperdoes
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Leishmania donovani: Hemolytic Activity of Promastigotes

Experimental Parasitology, 1994
A hemolytically active component was found to be present in Leishmania donovani promastigotes for the first time. It lysed human and rabbit erythrocytes to varying degrees. The optimal pH for the activity was found to be 5.8. The rate of hemolysis was dependent on both erythrocyte and parasite concentrations.
R, Chakravarty, M C, Sharma, A K, Gupta, N, Prakash, R, Saran   +4 more
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In Vitro Tryptophan Catabolism by Leishmania donovani donovani Promastigotes

The Journal of Protozoology, 1992
ABSTRACT. Metabolism of tryptophan by promastigotes of Leishmania donovani donovani was investigated in cells suspended in a simple buffer solution supplemented with glucose. Metabolites from supernatant and lysed cell pellets were analyzed by capillary gas liquid chromatography and 13C nuclear magnetic resonance spectroscopy, with structural ...
S, Leelayoova, D, Marbury, P M, Rainey, N E, Mackenzie, J E, Hall   +4 more
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