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Oxidation of Leucine by Leishmania donovani
The Journal of Protozoology, 1991ABSTRACT. The metabolism of leucine by Leishmania donovani was investigated. Washed promastigotes were incubated with (1‐14C]‐or [U‐14C]leucine or [1 ‐14C]α‐ketoisocaproate (KIC) and 14C02 release was measured. The amount of KIC‐derived acetyl‐CoA oxidized in the citric acid cycle was computed. Promastigotes from mid‐stationary phase cultures oxidized
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Leishmania donovani Tryparedoxin Peroxidase
2004Leishmanien sind intrazelluläre Parasiten, die für die Krankheit Leishmaniasis verantwortlich sind. Die Suche nach Therapieansätzen ergab, dass der Trypanothione-vermittelte Hydroperoxide-Metabolismus die "Achilles-Sehne" dieser Trypanosomatiden ist, da sie dem Angriff von ROS (Reactive Oxyzen Species) ausgesetzt sind, die dem aeroben Stoffwechsel des ...
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Macromolecular Synthesis in Leishmania donovani Amastigotes
The Journal of Parasitology, 1985Amastigotes (non-flagellated tissue forms) of Leishmania sp. reside and multiply within the phagolysosomes in tissue macrophages of vertebrate hosts. They are true obligate, intracellular parasites and do not persist as viable entities outside of host cells.
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Cellular Immunity to Leishmania Donovani
The Journal of Immunology, 1974Abstract C57BL/6J mice were subjected to various combinations of immunosuppressive treatments and infected i.v. with amastigotes of Leishmania donovani. In normal mice the parasite population reached its peak about 24 days post-infection, after which parasite numbers gradually declined but they were still detectable on day 60. The course
Clare B Skov, Donald W Twohy
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Leishmania donovani parasitaemia in Kenyan visceral leishmaniasis
Transactions of the Royal Society of Tropical Medicine and Hygiene, 1985Twenty Kenyan patients with visceral leishmaniasis were evaluated for the presence of Leishmania donovani in their peripheral blood. Smears, cultures and hamster inoculations detected parasitaemia in 11, 10 and six patients, respectively, and at least one method detected parasitaemia in 15 patients (75%).
Chulay, JD, Adoyo, MA, Githure, JI
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Karyotype Analysis of Leishmania Donovani
1989Kinetoplastid protozoa of the genus Leishmania are the causative agents of leishmaniasis which has recently been estimated to affect 20 million people, mainly in developing countries (Barker, 1987). A number of biochemical techniques have been applied to differentiate the organisms causing the various clinical forms of the disease, the most successful ...
Richard P. Bishop, Michael A. Miles
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Prevention of Leishmania donovani infection
BMJ, 2010Vector control is key to the success of the global elimination strategy Visceral leishmaniasis, the most severe form of leishmaniasis, is usually fatal in the absence of treatment. Together India, Nepal, and Bangladesh represent the biggest focus of visceral leishmaniasis in the world. Human to human transmission occurs through the bite of an infected
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Integrative oncology: Addressing the global challenges of cancer prevention and treatment
Ca-A Cancer Journal for Clinicians, 2022Jun J Mao,, Msce +2 more
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