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Leishmania donovani leishmaniasis in Cyprus
The Lancet Infectious Diseases, 20081recently discussed the emergence of Leishmania donovani in Cyprus. We would like to provide some additional data regarding possible vector species that might have caused the disease outbreak on this island. The presence of L donovani was reported in the eastern Mediterranean basin about 10 years ago in the vicinity of Kassab, northern Syria, when an ...
Maria, Antoniou +5 more
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Purine metabolism in Leishmania donovani and Leishmania braziliensis
Biochimica et Biophysica Acta (BBA) - General Subjects, 1978We have studied purine metabolism in the culture forms of Leishmania donovani and Leishmania braziliensis. These organisms are incapable of synthesizing purines de novo from glycine, serine, or formate and require an exogenous purine for growth. This requirement is better satisfied by adenosine or hypoxanthine than by guanosine.
J J, Marr, R L, Berens, D J, Nelson
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Adenine Phosphoribosyltransferase-Deficient Leishmania Donovani
1986Mutant promastigotes of Leishmania donovani deficient in adenine phosphoribosyltransferase (APRTase) have been isolated in medium containing 4-aminopyrazolopyrimidine. The generation of APRTase-deficient mutants occurred in two discrete steps. In the first step, clones were isolated with 50% of wildtype levels of APRTase activity.
K, Kaur, D M, Iovannisci, B, Ullman
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The Ultrastructure of Leishmania donovani
The Journal of Parasitology, 1956The structure of the intracellular form of Leishmania donovani as seen by the light microscope consists of a nucleus and usually a rod-like kinetoplast (Wenyon, 1926) within a homogeneous mass of cytoplasm, while the extracellular or culture form has, in addition to these structures, an anterior flagellum.
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Cell surface lipophosphoglycan of Leishmania donovani
Molecular and Biochemical Parasitology, 1987Based on a galactose oxidase/NaB[3H]4 technique of radiolabeling macromolecules, the major glycoconjugate (lipophosphoglycan) of Leishmania donovani promastigotes was determined to be located on the cell surface. Incorporated radioactivity was analyzed by gel filtration on Sephadex G-100, chromatography on ricin agglutinin-coupled agarose, and lability
D L, King, Y D, Chang, S J, Turco
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Lipophosphoglycan Antigen Shedding By Leishmania Donovani
Journal of Eukaryotic Microbiology, 1993ABSTRACT. The biochemical characterizations of lipophosphoglycans from various Leishmania species reported by other workers may or may not contain several types of lipophosphoglycan molecules. This is the first report in which a specific lipophosphoglycan has been defined by both its antigenie and electrophoretic properties. Furthermore, a purification
E S, Kaneshiro, M A, Wyder
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Leishmania donovani: Hemolytic Activity of Promastigotes
Experimental Parasitology, 1994A hemolytically active component was found to be present in Leishmania donovani promastigotes for the first time. It lysed human and rabbit erythrocytes to varying degrees. The optimal pH for the activity was found to be 5.8. The rate of hemolysis was dependent on both erythrocyte and parasite concentrations.
R, Chakravarty +4 more
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Glucose transport in Leishmania donovani promastigotes
Molecular and Biochemical Parasitology, 1984Mid-log phase Leishmania donovani promastigotes accumulated 2-deoxy-D-glucose (2-DOG) via a carrier mediated transport system, maintaining an apparent Km of 24.4 microM and a Vmax of 3.12 nmol mg-1 protein min-1. D-Glucose but not L-glucose competitively inhibited the 2-DOG transport with an apparent Ki of 18.7 microM.
D, Zilberstein, D M, Dwyer
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Leishmania (Leishmania) donovani subsp. would Nicolle 1908
2020Leishmania (Leishmania) donovani(Laveran et Mesnil, 1903) The record of L. donovani ZMON- 31 in Oman leads us to briefly discuss the taxonomic status and the geographical distribution of this zymodeme and closely related zymodemes. Starting in the 1980s, enzymatic taxonomy studies led to consider the linnean taxa L. donovani and L.
Rioux, Jean-Antoine +4 more
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