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Leishmania donovani leishmaniasis in Cyprus [PDF]
The Lancet Infectious Diseases, 2008 1recently discussed the emergence of Leishmania donovani in Cyprus. We would like to provide some additional data regarding possible vector species that might have caused the disease outbreak on this island. The presence of L donovani was reported in the eastern Mediterranean basin about 10 years ago in the vicinity of Kassab, northern Syria, when an ...
Apostolos Mazeris +5 more
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Purine metabolism in Leishmania donovani and Leishmania braziliensis
Biochimica et Biophysica Acta (BBA) - General Subjects, 1978We have studied purine metabolism in the culture forms of Leishmania donovani and Leishmania braziliensis. These organisms are incapable of synthesizing purines de novo from glycine, serine, or formate and require an exogenous purine for growth. This requirement is better satisfied by adenosine or hypoxanthine than by guanosine.
Randolph L. Berens +2 more
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Heme metabolism in promastigotes of Leishmania donovani
Molecular and Cellular Biochemistry, 1997Promastigotes of Leishmania donovani (Dd-8 strain) showed presence of important key enzymes of heme synthesizing (delta-aminolevulinic acid synthase and ferrochelatase) and degrading (heme oxygenase and biliverdin reductase) systems, classical leishmanicidal drugs viz allopurinol, amphotericin B, pentamidine and CDRI compound 93/202 inhibited the heme ...
Vikas C. Pandey +4 more
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The Ultrastructure of Leishmania donovani
The Journal of Parasitology, 1956The structure of the intracellular form of Leishmania donovani as seen by the light microscope consists of a nucleus and usually a rod-like kinetoplast (Wenyon, 1926) within a homogeneous mass of cytoplasm, while the extracellular or culture form has, in addition to these structures, an anterior flagellum.
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Solution structure of the lipophosphoglycan of Leishmania donovani
Biochemistry, 1992The three-dimensional solution structure of the repeating -PO4-6Gal beta 1-4Man alpha 1- disaccharide fragment of the lipophosphoglycan (LPG) derived from Leishmania donovani has been determined by use of a combination of homo- and heteronuclear NMR spin coupling constant measurements together with restrained molecular mechanical minimization and ...
S. W. Homans, Mehlert A, Turco Sj
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Stages in the life-cycle of Leishmania donovani
Transactions of the Royal Society of Tropical Medicine and Hygiene, 1960Abstract 1. 1) A technique for observing the phenomena associated with the first stages of infection of cells by flagellates of Leishmania donovani is described. In our experience flagellates enter only monocytes and there is a mutual attraction. They enter body first, and once inside the cell move freely, flagellum first.
R.J.V. Pulvertaft, G.F. Hoyle
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Characterization of strains of Leishmania donovani
Experimental Parasitology, 1966Abstract Even with the most standardized procedures yet available for in vivo trials, the intrastrain variations in the course of infection of Leishmania donovani in the hamster permit no easy assessment of variations among those tested by us from several parts of the world.
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Cell surface lipophosphoglycan of Leishmania donovani
Molecular and Biochemical Parasitology, 1987Based on a galactose oxidase/NaB[3H]4 technique of radiolabeling macromolecules, the major glycoconjugate (lipophosphoglycan) of Leishmania donovani promastigotes was determined to be located on the cell surface. Incorporated radioactivity was analyzed by gel filtration on Sephadex G-100, chromatography on ricin agglutinin-coupled agarose, and lability
Diane L. King +2 more
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Uptake and turnover of glucose in Leishmania donovani
Molecular and Biochemical Parasitology, 1993Glucose uptake and metabolism by Leishmania donovani promastigotes was studied using D-[14C]glucose in combination with the silicone oil centrifugation technique on organisms preadapted to different growth rates and glucose availability in the chemostat. The uptake step was differentiated from the subsequent metabolism by separation in time rather than
Frederik Opperdoes, B H Ter Kuile
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