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Leishmania donovani Tryparedoxin Peroxidase
2004Leishmanien sind intrazelluläre Parasiten, die für die Krankheit Leishmaniasis verantwortlich sind. Die Suche nach Therapieansätzen ergab, dass der Trypanothione-vermittelte Hydroperoxide-Metabolismus die "Achilles-Sehne" dieser Trypanosomatiden ist, da sie dem Angriff von ROS (Reactive Oxyzen Species) ausgesetzt sind, die dem aeroben Stoffwechsel des ...
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Leishmania donovani: Hemolytic Activity of Promastigotes
Experimental Parasitology, 1994A hemolytically active component was found to be present in Leishmania donovani promastigotes for the first time. It lysed human and rabbit erythrocytes to varying degrees. The optimal pH for the activity was found to be 5.8. The rate of hemolysis was dependent on both erythrocyte and parasite concentrations.
A. K. Gupta +4 more
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Karyotype Analysis of Leishmania Donovani
1989Kinetoplastid protozoa of the genus Leishmania are the causative agents of leishmaniasis which has recently been estimated to affect 20 million people, mainly in developing countries (Barker, 1987). A number of biochemical techniques have been applied to differentiate the organisms causing the various clinical forms of the disease, the most successful ...
Michael A. Miles, Richard P. Bishop
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Glucose transport in Leishmania donovani promastigotes
Molecular and Biochemical Parasitology, 1984Mid-log phase Leishmania donovani promastigotes accumulated 2-deoxy-D-glucose (2-DOG) via a carrier mediated transport system, maintaining an apparent Km of 24.4 microM and a Vmax of 3.12 nmol mg-1 protein min-1. D-Glucose but not L-glucose competitively inhibited the 2-DOG transport with an apparent Ki of 18.7 microM.
Dennis M. Dwyer, Dan Zilberstein
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Chromosome size polymorphisms of Leishmania donovani
Molecular and Biochemical Parasitology, 1987A minimum of 22 chromosomes were found in all Leishmania donovani stocks examined by orthogonal field alternation gel electrophoresis (OFAGE). Chromosome sizes ranged from approximately 270 to 4000 kb. Certain chromosomes were polymorphic in size between stocks and chromosomes present in some stocks had no apparent equivalent in others.
Michael A. Miles, Richard P. Bishop
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Prevention of Leishmania donovani infection
BMJ, 2010Vector control is key to the success of the global elimination strategy Visceral leishmaniasis, the most severe form of leishmaniasis, is usually fatal in the absence of treatment. Together India, Nepal, and Bangladesh represent the biggest focus of visceral leishmaniasis in the world. Human to human transmission occurs through the bite of an infected
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In Vitro Tryptophan Catabolism by Leishmania donovani donovani Promastigotes
The Journal of Protozoology, 1992ABSTRACT. Metabolism of tryptophan by promastigotes of Leishmania donovani donovani was investigated in cells suspended in a simple buffer solution supplemented with glucose. Metabolites from supernatant and lysed cell pellets were analyzed by capillary gas liquid chromatography and 13C nuclear magnetic resonance spectroscopy, with structural ...
Saovanee Leelayoova +4 more
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Adenine Phosphoribosyltransferase-Deficient Leishmania Donovani
1986Mutant promastigotes of Leishmania donovani deficient in adenine phosphoribosyltransferase (APRTase) have been isolated in medium containing 4-aminopyrazolopyrimidine. The generation of APRTase-deficient mutants occurred in two discrete steps. In the first step, clones were isolated with 50% of wildtype levels of APRTase activity.
Kiran J Kaur +2 more
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Macromolecular Synthesis in Leishmania donovani Amastigotes
The Journal of Parasitology, 1985Amastigotes (non-flagellated tissue forms) of Leishmania sp. reside and multiply within the phagolysosomes in tissue macrophages of vertebrate hosts. They are true obligate, intracellular parasites and do not persist as viable entities outside of host cells.
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A new experimental host of Leishmania donovani
Experimental Parasitology, 1963Abstract The bush baby ( Galago senegalensis senegalensis ) has been shown to be more susceptible than the hamster to infection upon intraperitoneal injection with culture leptomonads of L. donovani . Death as early as 15 weeks after inoculation, with intense parasitism of spleen, bone marrow, liver, heart muscle, and peripheral blood is reported ...
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