Results 231 to 240 of about 14,623 (258)
Some of the next articles are maybe not open access.
International Journal for Parasitology, 2003
The present study describes the cloning and characterisation of a gene encoding a cysteine proteinase isoform, Llacys1, expressed in amastigote forms of Leishmania (L.) amazonensis. Recombinant clones containing the Llacys1 gene were isolated from genomic DNA by PCR amplification and screening of an amastigote cDNA library.
Fernanda, Lasakosvitsch +4 more
openaire +2 more sources
The present study describes the cloning and characterisation of a gene encoding a cysteine proteinase isoform, Llacys1, expressed in amastigote forms of Leishmania (L.) amazonensis. Recombinant clones containing the Llacys1 gene were isolated from genomic DNA by PCR amplification and screening of an amastigote cDNA library.
Fernanda, Lasakosvitsch +4 more
openaire +2 more sources
Pravastatin modulates macrophage functions of Leishmania (L.) amazonensis-infected BALB/c mice
Experimental Parasitology, 2013The control of leishmaniases poses an important challenge due to the scarcity and toxicity of the pharmacological options available. We have previously shown that pravastatin significantly improves the course of the disease in Leishmania (L.) amazonensis-infected BALB/c mice.
Carlos S, Kückelhaus +3 more
openaire +2 more sources
Parasitology Research, 2010
Leishmania parasites cause a worldwide public health disease and its treatment is still based on pentavalent antimonials which present financial and toxicologic limitations. Some nucleosidic derivatives have demonstrated anti-leishmanial properties and this study aims to evaluate the in vitro morphologic alterations and growth inhibition of Leishmania (
Carolina A, Araújo +7 more
openaire +2 more sources
Leishmania parasites cause a worldwide public health disease and its treatment is still based on pentavalent antimonials which present financial and toxicologic limitations. Some nucleosidic derivatives have demonstrated anti-leishmanial properties and this study aims to evaluate the in vitro morphologic alterations and growth inhibition of Leishmania (
Carolina A, Araújo +7 more
openaire +2 more sources
Parasitology Research, 2010
The antiproliferative effect of julocrotine, an alkaloid isolated from Croton pullei var. glabrior (Euphorbiaceae), was studied in the macrophage amastigote and promastigote stages of the protozoan Leishmania (L.) amazonensis, which causes cutaneous leishmaniasis in the New World.
Leda R C, Guimarães +7 more
openaire +2 more sources
The antiproliferative effect of julocrotine, an alkaloid isolated from Croton pullei var. glabrior (Euphorbiaceae), was studied in the macrophage amastigote and promastigote stages of the protozoan Leishmania (L.) amazonensis, which causes cutaneous leishmaniasis in the New World.
Leda R C, Guimarães +7 more
openaire +2 more sources
N-acetyl-l-cysteine reduces the parasitism of BALB/c mice infected with Leishmania amazonensis
Parasitology Research, 2007Leishmania amazonensis infection leads to progressive diseases in a majority of inbred strains of mice. Glutathione (GSH) participates in a large number of cellular phenomena and seems to be essential for several immune functions, including host defense during leishmaniasis. In this study, we evaluated the effects of N-acetyl-L: -cysteine (NAC), as GSH
Marta Chagas, Monteiro +6 more
openaire +2 more sources
Lantana camara L. induces a multi-targeted cell death process in Leishmania amazonensis
Journal of EthnopharmacologyLantana camara L. is a species known for its broad spectrum of bioactivities and is commonly used in folk therapy to address inflammatory, dermatological, gastrointestinal, intestinal worms and protozoan diseases. It boasts a diverse array of secondary metabolites such as terpenes, flavonoids, and saponins.
Ari Sérgio de Oliveira Lemos +9 more
openaire +2 more sources
Experimental Parasitology, 1989
L-leucine-methyl ester (Leu-OMe) kills Leishmania mexicana amazonensis amastigotes by a mechanism which requires proteolytic cleavage of the ester. N-Benzyloxycarbonyl-phenylalanyl-alanyl diazomethane (Z-Phe-AlaCHN2), a specific and irreversible inhibitor of cysteine proteinases, was used to characterize the enzymes involved in parasite destruction. It
S C, Alfieri +3 more
openaire +2 more sources
L-leucine-methyl ester (Leu-OMe) kills Leishmania mexicana amazonensis amastigotes by a mechanism which requires proteolytic cleavage of the ester. N-Benzyloxycarbonyl-phenylalanyl-alanyl diazomethane (Z-Phe-AlaCHN2), a specific and irreversible inhibitor of cysteine proteinases, was used to characterize the enzymes involved in parasite destruction. It
S C, Alfieri +3 more
openaire +2 more sources
2017
1 Background Leishmaniasis is a neglected disease caused by many Leishmania species, belonging to subgenera Leishmania (Leishmania) and Leishmania (Viannia). Several qPCR-based molecular diagnostic approaches have been reported for detection and quantification of Leishmania species. Many of these approaches use the kinetoplast DNA (kDNA) minicircles as
Marcello Ceccarelli +7 more
openaire +1 more source
1 Background Leishmaniasis is a neglected disease caused by many Leishmania species, belonging to subgenera Leishmania (Leishmania) and Leishmania (Viannia). Several qPCR-based molecular diagnostic approaches have been reported for detection and quantification of Leishmania species. Many of these approaches use the kinetoplast DNA (kDNA) minicircles as
Marcello Ceccarelli +7 more
openaire +1 more source
Effect of Copaifera reticulata on amastigote forms of Leishmania (L.) amazonensis
Planta Medica, 2008AO dos Santos +5 more
openaire +1 more source