Results 61 to 70 of about 2,247 (156)

Therapeutic Effect of Barberry (Berberis vulgaris) Root Extract on Experimental Cutaneous Leishmaniosis in a BALB/c Mouse Model

Veterinary Medicine and Science, Volume 11, Issue 5, September 2025.
Barberry (Berberis vulgaris) root extract shows potential in treating cutaneous leishmaniasis caused by Leishmania major. In a BALB/c mouse model, treatment significantly reduced wound size and parasite load while enhancing inflammatory markers IL‐1 and IL‐6. These results highlight barberry's therapeutic promise against leishmaniasis.
Sadegh Shirian, Morteza Norouzi Cholcheh, Saeed Habibian Dehkordi, Behnam Bakhtiari Moghadam   +3 more
wiley   +1 more source

Expression of a rK39 homologue from an Iranian Leishmania infantum isolate in Leishmania tarentolae for serodiagnosis of visceral leishmaniasis

Parasites & Vectors, 2019
Background Kinesin-related gene diversity among strains and species of Leishmania may impact the sensitivity and specificity of serodiagnostic tests for visceral leishmaniasis (VL).
Zahra Rezaei, Nick Van Reet, Gholamreza Pouladfar, Vera Kühne, Amin Ramezani, Bahador Sarkari, Bahman Pourabbas, Philippe Büscher   +7 more
doaj   +1 more source

Identification of Leishmania species by high-resolution DNA dissociation in cases of American cutaneous leishmaniasis, [PDF]

Anais Brasileiros de Dermatologia
Background American cutaneous leishmaniasis is an infectious dermatosis caused by protozoa of the genus Leishmania, which comprises a broad spectrum of clinical manifestations depending on the parasite species involved in the infections and the ...
John Verrinder Veasey, Ricardo Andrade Zampieri, Rute Facchini Lellis, Thaís Helena Proença de Freitas, Lucile Maria Floeter Winter   +4 more
doaj   +2 more sources

IL‐12 and IFN‐γ in Response to Leishmania Infantum Antigens in Felines From an Endemic Area for Visceral Leishmaniasis

Parasite Immunology, Volume 47, Issue 8, August 2025.
ABSTRACT Visceral leishmaniasis is a potentially fatal zoonosis with an increasing incidence. Most infected felines present the disease in its subclinical form and demonstrate greater resistance to parasitemia than dogs. However, the role of cellular immunity in felines is still poorly understood. This study measured serum levels of interleukin (IL)‐12
João Victor Lé Lode, Lucas Takeshi Siqueira Ito, Gisele Mitsue Umino, Valéria Marçal Felix de Lima   +3 more
wiley   +1 more source

Integration of Machine Learning‐QSAR and Polypharmacology in Drug Discovery for Leishmaniasis Using Natural and Repurposed Compounds

ChemistrySelect, Volume 10, Issue 21, June 4, 2025.
Leishmaniasis affects over 1 billion people worldwide, with current treatments limited by toxicity and efficacy. This study used machine learning (ML), QSAR, and polypharmacology to identify potential drug candidates, analyzing 12,072 compounds with random forest and XGBoost models.
Laís Salvador do Amaral, Amiel Artur Morais, Alexandre de Fátima Cobre, Raul Edison Luna Lazo, Dile Pontarolo Stremel, Jaqueline Carneiro, Luana Mota Ferreira, Roberto Pontarolo   +7 more
wiley   +1 more source

Cutaneous Leishmaniasis Mimicking a Nasal Tumor: A Case Report

Case Reports in Infectious Diseases, Volume 2025, Issue 1, 2025.
Leishmaniasis is a disease caused by Leishmania protozoa that is transmitted to the patient by sand flies. Depending on the Leishmania species, the disease can present with cutaneous, mucosal, or multiorgan involvement. Cutaneous leishmaniasis can present with diverse clinical manifestations mimicking other diseases.
Maryam Hekmat, Mohammad Reza Namazi, Amir Hossein Najibi, Babak Shirazi Yeganeh, Negin Fazelzadeh Haghighi, Larry M. Bush   +5 more
wiley   +1 more source

Genetic diversity of Leishmania infantum field populations from Brazil

Memorias do Instituto Oswaldo Cruz, 2012
Leishmania infantum (syn. Leishmania chagasi) is the etiological agent of visceral leishmaniasis (VL) in Brazil. The epidemiology of VL is poorly understood.
Marcela Segatto, Lucas Secchim Ribeiro, Dorcas Lamounier Costa, Carlos Henrique Nery Costa, Márcia Rosa de Oliveira, Sílvio Fernando Guimarães Carvalho, Andréa Mara Macedo, Helder Magno Silva Valadares, Reynaldo Dietze, Cristiana Ferreira Alves de Brito, Elenice Moreira Lemos   +10 more
doaj   +1 more source

Mucocutaneous Leishmaniasis With Oral Involvement: A Case Report

Case Reports in Dentistry, Volume 2025, Issue 1, 2025.
The primary objective of the present study is the retrospective analysis of a clinical case of oral leishmaniasis treated at Parma Hospital and a review of the literature on mucosal leishmaniasis (ML) with oral cavity involvement. We report the case of a patient diagnosed in 2017 with mucocutaneous leishmaniasis who was referred to our clinic due to ...
Pierpaolo De Francesco, Paolo Vescovi, Claudio Feliciani, Roberta Iaria, Luigi Corcione, Ilaria Giovannacci, Vlaho Brailo   +6 more
wiley   +1 more source

Expression of leukosialin (CD43) defines a major intrahepatic T cell subset associated with protective responses in visceral leishmaniasis

Parasites & Vectors, 2015
Background Leishmaniasis is a neglected vector-borne tropical disease caused by Leishmania protozoa that are transmitted to mammalian hosts by infected sand flies.
Dirlei Nico, Naiara Maran, Leonardo Santos, Erivan Schnaider Ramos-Junior, Natália Rodrigues Mantuano, Joseane Lima Prado Coutinho, Andre Macedo Vale, Celio Geraldo Freire-de-Lima, Adriane Todeschini, Juliany Cola Fernandes Rodrigues, Clarisa Beatriz Palatnik-de-Sousa, Alexandre Morrot   +11 more
doaj   +1 more source

A Century of Epidemiological Advances in Cutaneous and Visceral Leishmaniasis in Algeria

Journal of Parasitology Research, Volume 2025, Issue 1, 2025.
Leishmaniasis is a group of diseases transmitted by sandflies, affecting humans and animals, with three clinical presentations: cutaneous, mucosal, and visceral. The disease is caused by the parasite Leishmania and is a significant global health issue, with approximately two million cases annually and 350 million people at risk.
Naouel Eddaikra, Razika Benikhlef, Denis Sereno, Satabdi Datta Choudhury   +3 more
wiley   +1 more source