Results 91 to 100 of about 6,523 (205)

Antileishmanial activity and immunomodulatory effect of secosubamolide, a butanolide isolated from Nectandra oppositifolia (Lauraceae)

Journal of Venomous Animals and Toxins including Tropical Diseases
Background: Visceral leishmaniasis is a complex neglected tropical disease caused by Leishmania donovani complex. Its current treatment reveals strong limitations, especially high toxicity.
Thais A. da Costa-Silva, Geanne A. Alves Conserva, Andrés J. Galisteo Jr, Andre G. Tempone, João Henrique G. Lago   +4 more
doaj   +1 more source

Cardiac Lesions in 30 Dogs Naturally Infected With Leishmania infantum chagasi [PDF]

Veterinary Pathology, 2013
The hearts of 30 dogs naturally infected with Leishmania infantum chagasi were evaluated histologically and immunohistochemically. Myocardial lesions were detected in all dogs, including lymphoplasmacytic myocarditis (27/30), myonecrosis (24/30), increased interstitial collagen (22/30), lepromatous-type granulomatous myocarditis (7/30), fibrinoid ...
Rosa, F. A., Leite, J. H. A. C., Braga, E. T., Moreira, P. R. R., Baltazar, F. H., Biondo, A. W., Padua, P. P. M., Vasconcelos, R. O., Camacho, A. A., Ferreira, W. L., Machado, G. F., Marcondes, M.   +11 more
openaire   +3 more sources

Resposta imune na infecção por Leishmania infantum em modelo murino [PDF]

, 2011
As leishmanioses são doenças causadas por protozoários do género Leishmania que são parasitas intracelulares obrigatórios das células fagocíticas.
Cabrita, Élia, Campino, Lenea, Maia, Carla   +2 more
core   +2 more sources

Expression of leukosialin (CD43) defines a major intrahepatic T cell subset associated with protective responses in visceral leishmaniasis

Parasites & Vectors, 2015
Background Leishmaniasis is a neglected vector-borne tropical disease caused by Leishmania protozoa that are transmitted to mammalian hosts by infected sand flies.
Dirlei Nico, Naiara Maran, Leonardo Santos, Erivan Schnaider Ramos-Junior, Natália Rodrigues Mantuano, Joseane Lima Prado Coutinho, Andre Macedo Vale, Celio Geraldo Freire-de-Lima, Adriane Todeschini, Juliany Cola Fernandes Rodrigues, Clarisa Beatriz Palatnik-de-Sousa, Alexandre Morrot   +11 more
doaj   +1 more source

Topical Resiquimod Protects against Visceral Infection with Leishmania infantum chagasi in Mice [PDF]

Clinical and Vaccine Immunology, 2014
ABSTRACTNew prevention and treatment strategies are needed for visceral leishmaniasis, particularly ones that can be deployed simply and inexpensively in areas where leishmaniasis is endemic. Synthetic molecules that activate Toll-like receptor 7 and 8 (TLR7/8) pathways have previously been demonstrated to enhance protection against cutaneous ...
Noah, Craft, Ron, Birnbaum, Natalie, Quanquin, Marie Crisel B, Erfe, Cara, Quant, Jacquelyn, Haskell, Kevin W, Bruhn   +6 more
openaire   +2 more sources

Feline leishmaniosis due to Leishmania infantum (syn. L. chagasi)

Journal of the Hellenic Veterinary Medical Society, 2018
From the beginning of the 20th century, feline infections by at least eight different Leishmania species have been sporadically reported, worldwide. In the Mediterranean countries, feline infection imposed by L. infantum, the aetiological agent of canine leishmaniosis and human visceral and cutaneous leishmaniasis, is of particular importance, because ...
M CHATZIS, MN SARIDOMICHELAKIS, AF KOUTINAS   +2 more
openaire   +2 more sources

Rattus norvegicus(Rodentia: Muridae) Infected byLeishmania(Leishmania)infantum(syn.Le. chagasi) in Brazil [PDF]

BioMed Research International, 2014
In the present study we surveyed the fauna of phlebotomine sand flies and small mammals in peridomestic areas from a Brazilian municipality where the American cutaneous leishmaniasis (ACL) is endemic. A total of 608 female phlebotomine sand flies were captured during nine months in 2009 and 2010.
Fabiana de Oliveira Lara-Silva, Ricardo Andrade Barata, Érika Monteiro Michalsky, Eduardo de Castro Ferreira, Maria Olímpia Garcia Lopes, Aimara da Costa Pinheiro, Consuelo Latorre Fortes-Dias, Edelberto Santos Dias   +7 more
openaire   +2 more sources

Sertraline Delivered in Phosphatidylserine Liposomes Is Effective in an Experimental Model of Visceral Leishmaniasis [PDF]

, 2019
Liposomes containing phosphatidylserine (PS) has been used for the delivery of drugs into the intramacrophage milieu. Leishmania (L.) infantum parasites live inside macrophages and cause a fatal and neglected viscerotropic disease, with a toxic treatment.
Allen, Alvar, Andrade-Neto, Andrews, Ansari, Botero, Buffet, Carnielli, Carvalheiro, Chakravarty, Chan, Costa-Silva, Costa-Silva, Cotterell, Croft, Croft, Cunha-Júnior, Deshmane, Dey, Dhanikula, Ellis, Evans, Faleiro, Furtado, Guerra, Huang, Kansal, Kreilgaard, Lamy, Laverman, Lima, Lindoso, Lourie, Mattock, Mikus, Mukherjee, Mukherjee, Murdoch, Murray, Onaolapo, Ong, Ostrosky-Zeichner, Palit, Park, Pinto, Reagan-Shaw, Rebello, Reimão, Richardson, Ronfeld, Santuzzi, Stewart, Tempone, Tempone, Tempone, Tsushima, Walton, Yardley   +57 more
core   +2 more sources

Performance of Extracellular Vesicles From Leishmania (Leishmania) infantum for Serological Diagnosis of Human and Canine Visceral Leishmaniasis

Journal of Parasitology Research, Volume 2025, Issue 1, 2025.
Visceral leishmaniasis (VL) is a zoonotic disease in which dogs are the main reservoirs. Until now, the serological tests do not present satisfactory sensitivity for diagnosis of these hosts. One of the functions of extracellular vesicles (EVs) is related to immunological host response.
Allecineia Bispo da Cruz, Francieli Marinho Carneiro, Noemi Nosomi Taniwaki, Gislene Mitsue Namiyama, Débora Oliveira dos Santos, Katia Gomes Castellão, Isabelle Martins Ribeiro Ferreira, Roberto Mitsuyoshi Hiramoto, Vera Lucia Pereira-Chioccola, Bernard Marchand   +9 more
wiley   +1 more source

Cross-protective effect of a combined L5 plus L3 Leishmania major ribosomal protein based vaccine combined with a Th1 adjuvant in murine cutaneous and visceral leishmaniasis

Parasites & Vectors, 2014
Background Two Leishmania major ribosomal proteins L3 (LmL3) and L5 (LmL5) have been described as protective molecules against cutaneous leishmaniasis due to infection with L.
Laura Ramirez, Laura Corvo, Mariana C Duarte, Miguel A Chávez-Fumagalli, Diogo G Valadares, Diego M Santos, Camila I de Oliveira, Marta R Escutia, Carlos Alonso, Pedro Bonay, Carlos AP Tavares, Eduardo AF Coelho, Manuel Soto   +12 more
doaj   +1 more source