Results 101 to 110 of about 6,846 (239)

Integration of Machine Learning‐QSAR and Polypharmacology in Drug Discovery for Leishmaniasis Using Natural and Repurposed Compounds

ChemistrySelect, Volume 10, Issue 21, June 4, 2025.
Leishmaniasis affects over 1 billion people worldwide, with current treatments limited by toxicity and efficacy. This study used machine learning (ML), QSAR, and polypharmacology to identify potential drug candidates, analyzing 12,072 compounds with random forest and XGBoost models.
Laís Salvador do Amaral, Amiel Artur Morais, Alexandre de Fátima Cobre, Raul Edison Luna Lazo, Dile Pontarolo Stremel, Jaqueline Carneiro, Luana Mota Ferreira, Roberto Pontarolo   +7 more
wiley   +1 more source

Expression of leukosialin (CD43) defines a major intrahepatic T cell subset associated with protective responses in visceral leishmaniasis

Parasites & Vectors, 2015
Background Leishmaniasis is a neglected vector-borne tropical disease caused by Leishmania protozoa that are transmitted to mammalian hosts by infected sand flies.
Dirlei Nico, Naiara Maran, Leonardo Santos, Erivan Schnaider Ramos-Junior, Natália Rodrigues Mantuano, Joseane Lima Prado Coutinho, Andre Macedo Vale, Celio Geraldo Freire-de-Lima, Adriane Todeschini, Juliany Cola Fernandes Rodrigues, Clarisa Beatriz Palatnik-de-Sousa, Alexandre Morrot   +11 more
doaj   +1 more source

Rattus norvegicus(Rodentia: Muridae) Infected byLeishmania(Leishmania)infantum(syn.Le. chagasi) in Brazil [PDF]

BioMed Research International, 2014
In the present study we surveyed the fauna of phlebotomine sand flies and small mammals in peridomestic areas from a Brazilian municipality where the American cutaneous leishmaniasis (ACL) is endemic. A total of 608 female phlebotomine sand flies were captured during nine months in 2009 and 2010.
Fabiana de Oliveira Lara-Silva, Ricardo Andrade Barata, Érika Monteiro Michalsky, Eduardo de Castro Ferreira, Maria Olímpia Garcia Lopes, Aimara da Costa Pinheiro, Consuelo Latorre Fortes-Dias, Edelberto Santos Dias   +7 more
openaire   +2 more sources

Cross-protective effect of a combined L5 plus L3 Leishmania major ribosomal protein based vaccine combined with a Th1 adjuvant in murine cutaneous and visceral leishmaniasis

Parasites & Vectors, 2014
Background Two Leishmania major ribosomal proteins L3 (LmL3) and L5 (LmL5) have been described as protective molecules against cutaneous leishmaniasis due to infection with L.
Laura Ramirez, Laura Corvo, Mariana C Duarte, Miguel A Chávez-Fumagalli, Diogo G Valadares, Diego M Santos, Camila I de Oliveira, Marta R Escutia, Carlos Alonso, Pedro Bonay, Carlos AP Tavares, Eduardo AF Coelho, Manuel Soto   +12 more
doaj   +1 more source

Vaccination with L. infantum chagasi nucleosomal histones confers protection against new world cutaneous leishmaniasis caused by Leishmania braziliensis.

PLoS ONE, 2012
BackgroundNucleosomal histones are intracellular proteins that are highly conserved among Leishmania species. After parasite destruction or spontaneous lysis, exposure to these proteins elicits a strong host immune response.
Marcia W Carneiro, Diego M Santos, Kiyoshi F Fukutani, Jorge Clarencio, Jose Carlos Miranda, Claudia Brodskyn, Aldina Barral, Manoel Barral-Netto, Manuel Soto, Camila I de Oliveira   +9 more
doaj   +1 more source

A Century of Epidemiological Advances in Cutaneous and Visceral Leishmaniasis in Algeria

Journal of Parasitology Research, Volume 2025, Issue 1, 2025.
Leishmaniasis is a group of diseases transmitted by sandflies, affecting humans and animals, with three clinical presentations: cutaneous, mucosal, and visceral. The disease is caused by the parasite Leishmania and is a significant global health issue, with approximately two million cases annually and 350 million people at risk.
Naouel Eddaikra, Razika Benikhlef, Denis Sereno, Satabdi Datta Choudhury   +3 more
wiley   +1 more source

New record of preclinical diagnosis of American visceral leishmaniasis in Amazonian Brazil encourages optimizing disease control

Parasite Epidemiology and Control, 2020
The clinical-immunological spectrum of human Leishmania (L.) infantum chagasi-infection in Amazonian Brazil has recently been reviewed based on the combined use of the delayed-type hypersensitivity (DTH) and indirect fluorescence antibody test (IFAT-IgG ...
Luciana Lima, Thiago Vasconcelos-dos-Santos, Marliane Campos, Patrícia Karla Ramos, Claudia Gomes, Marcia Laurenti, Vania da Matta, Carlos Corbett, Fernando Silveira   +8 more
doaj   +1 more source

Risk factors for visceral leishmaniasis in a new epidemic site in Amhara Region, Ethiopia [PDF]

, 2009
We conducted a case-control study to evaluate risk factors for visceral leishmaniasis during an epidemic in a previously unaffected district of Ethiopia. We also collected blood and bone marrow specimens from dogs in the outbreak villages.
Alvar, Jorge, Aparicio, Pilar, Argaw, Daniel, Bashaye, Seife, Bern, Caryn, Cañavate, Carmen, Chicharro, Carmen, Herrero, Merce, Mulugeta, Abate, Nieto, Javier, Nombela, Nohelly, Vélez, Iván Darío   +11 more
core   +1 more source

Studies in the mouse model identify strain variability as a major determinant of disease outcome in Leishmania infantum infection [PDF]

, 2015
Visceral leishmaniasis is a severe and potentially fatal disease caused by protozoa of the genus Leishmania, transmitted by phlebotomine sandflies. In Europe and the Mediterranean region, L.
Appelberg, Rui, Cortes, Sofia, Cruz, Tânia, Fernandes, Ana, Gomes, Maria Salomé, Marques, Filipe, Marques, Joana Moreira, Neves, João Vilares, Rocha, Eduardo, Rodrigues, Pedro, Silva, Tânia, Tomás, Ana M., Vale-Costa, Sílvia   +12 more
core   +2 more sources

Performance of Extracellular Vesicles From Leishmania (Leishmania) infantum for Serological Diagnosis of Human and Canine Visceral Leishmaniasis

Journal of Parasitology Research, Volume 2025, Issue 1, 2025.
Visceral leishmaniasis (VL) is a zoonotic disease in which dogs are the main reservoirs. Until now, the serological tests do not present satisfactory sensitivity for diagnosis of these hosts. One of the functions of extracellular vesicles (EVs) is related to immunological host response.
Allecineia Bispo da Cruz, Francieli Marinho Carneiro, Noemi Nosomi Taniwaki, Gislene Mitsue Namiyama, Débora Oliveira dos Santos, Katia Gomes Castellão, Isabelle Martins Ribeiro Ferreira, Roberto Mitsuyoshi Hiramoto, Vera Lucia Pereira-Chioccola, Bernard Marchand   +9 more
wiley   +1 more source