Results 271 to 280 of about 5,616,372 (322)
ATR, a DNA damage kinase, modulates DNA replication timing in Leishmania major
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CABI Compendium, 2022
This datasheet on Leishmania major covers Identity, Distribution, Hosts/Species Affected, Vectors & Intermediate Hosts.
semanticscholar +1 more source
This datasheet on Leishmania major covers Identity, Distribution, Hosts/Species Affected, Vectors & Intermediate Hosts.
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The regulation of immunity to Leishmania major.
Annual Review of Immunology, 1995Experimental infection with the intracellular protozoan Leishmania major constitutes a particularly versatile model for assessing the role of CD4+ subset development in the host response to infectious disease. The association of Th1 development with control of infection, and of Th2 cell development with progressive disease, has been well established ...
S. Reiner, R. Locksley
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Folylpolyglutamates in Leishmania major
Biochemical and Biophysical Research Communications, 1987The intracellular folates of the protozoan parasite Leishmania major have been examined. About 95% of the exogenous [3H]folate accumulated by the protozoan is metabolized to polyglutamate conjugates within 65 hr, and the intracellular folates are about forty-fold concentrated over the folate in the medium.
D V, Santi, P, Nolan, B, Shane
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Brazilian Leishmania Stocks Phenotypically Similar to Leishmania Major
The American Journal of Tropical Medicine and Hygiene, 1985Screening by enzyme electrophoresis of isolates of New World Leishmania from different geographic areas revealed a number of stocks with enzyme profiles different from those produced by reference strains of described subspecies of L. mexicana, L. braziliensis, and L. donovani.
H, Momen +5 more
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Trypanothione biosynthesis in Leishmania major
Molecular and Biochemical Parasitology, 2005Trypanothione plays a crucial role in regulation of intracellular thiol redox balance and in defence against chemical and oxidant stress. Crithidia fasciculata requires two enzymes for the formation of trypanothione, namely glutathionylspermidine synthetase (GspS; EC 6.3.1.8) and a glutathionylspermidine-dependent trypanothione synthetase (TryS; EC 6.3.
Oza, Sandra L. +3 more
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Leishmania major infection: the overture
Parasitology Today, 1995Local infection of mice with Leishmania major results in either healing or death depending on the preferential action of Th1 or Th2 T helper cells, respectively. Although the parasite-induced T-cell responses and their consequences for the disease are well understood, relatively little is known about the initial events that kindle the adaptive immune ...
W, Solbach, T, Laskay
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Ubiquinone biosynthesis in Leishmania major promastigotes
International Journal for Parasitology, 1995Promastigotes of Leishmania major contain a ubiquinone which has a side chain made up of nine isoprene subunits (UQ9). Incorporation of radioactivity from [14C] acetate and [14C] mevalonate into ubiquinone as well as the identification of hydroxymethylglutaryl coenzyme A reductase (HMG CoA reductase), and mevalonate kinase indicate that the isoprenoid ...
G, Ranganathan, A J, Mukkada
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Extracellular phosphorylation in the parasite, Leishmania major
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1990Leishmania major promastigotes were analyzed for the presence of protein phosphatase activity in intact cells and membrane-enriched fractions. Parasite phosphoproteins, phosphorylated in live cells with [gamma-32P]adenosine 5'-triphosphate (ATP) and an endogenous leishmanial ectokinase, were dephosphorylated by endogenous protein phosphatase-like ...
D S, Lester, T, Hermoso, C L, Jaffe
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