Results 101 to 110 of about 9,389 (214)

Comparison of Leishmania typing results obtained from 16 European clinical laboratories in 2014 [PDF]

, 2016
Leishmaniasis is a vector-borne disease which is endemic in 98 countries worldwide [1]. It is caused by protozoan parasites of the genus Leishmania, which are transmitted by female sand flies of the genera Lutzomyia and Phlebotomus.
Bart, A., Chicharro, C., Cortes, S., Di Muccio, T., Dujardin, J., Felger, I., Grimm, F., Harms, G. [u.v.m.], Paglia, M. G., Van der Auwera, G.   +9 more
core   +1 more source

IL‐12 and IFN‐γ in Response to Leishmania Infantum Antigens in Felines From an Endemic Area for Visceral Leishmaniasis

Parasite Immunology, Volume 47, Issue 8, August 2025.
ABSTRACT Visceral leishmaniasis is a potentially fatal zoonosis with an increasing incidence. Most infected felines present the disease in its subclinical form and demonstrate greater resistance to parasitemia than dogs. However, the role of cellular immunity in felines is still poorly understood. This study measured serum levels of interleukin (IL)‐12
João Victor Lé Lode, Lucas Takeshi Siqueira Ito, Gisele Mitsue Umino, Valéria Marçal Felix de Lima   +3 more
wiley   +1 more source

Increasing the digital repository of DNA barcoding sequences of sand flies (Psychodidae: Phlebotominae) [PDF]

, 2019
Sand f ly identification is complex because it depends on the expertise of the taxonomist. The females show subtle morphological differences and the occurrence of the species complexes are usual in this taxon.
Almiron, Walter Ricardo, Laurito, Magdalena, Ontivero, Iliana Mayra   +2 more
core   +1 more source

Integration of Machine Learning‐QSAR and Polypharmacology in Drug Discovery for Leishmaniasis Using Natural and Repurposed Compounds

ChemistrySelect, Volume 10, Issue 21, June 4, 2025.
Leishmaniasis affects over 1 billion people worldwide, with current treatments limited by toxicity and efficacy. This study used machine learning (ML), QSAR, and polypharmacology to identify potential drug candidates, analyzing 12,072 compounds with random forest and XGBoost models.
Laís Salvador do Amaral, Amiel Artur Morais, Alexandre de Fátima Cobre, Raul Edison Luna Lazo, Dile Pontarolo Stremel, Jaqueline Carneiro, Luana Mota Ferreira, Roberto Pontarolo   +7 more
wiley   +1 more source

Virulence factor RNA transcript expression in the Leishmania Viannia subgenus: influence of species, isolate source, and Leishmania RNA virus-1

Tropical Medicine and Health, 2019
Background Leishmania RNA virus-1 (LRV1) is a double-stranded RNA virus identified in 20–25% of Viannia—species endemic to Latin America, and is believed to accelerate cutaneous to mucosal leishmaniasis over time.
Ruwandi Kariyawasam, Avinash N. Mukkala, Rachel Lau, Braulio M. Valencia, Alejandro Llanos-Cuentas, Andrea K. Boggild   +5 more
doaj   +1 more source

Evaluation of an in vitro and in vivo model for experimental infection with Leishmania (Viannia) braziliensis and L. (V.) peruviana

Parasitology, 2007
SUMMARYLeishmania (Viannia) braziliensis and L. (V.) peruviana are two parasite species characterized by a very different pathogenicity in humans despite a high genetic similarity. We hypothesized previously that L. (V.) peruviana would descend from L. (V.) braziliensis and would have acquired its ‘peruviana’ character during the southward colonization
Gamboa, D., Torres, K., De Doncker, S., Zimic, M., Arevalo, J., Dujardin, J. C.   +5 more
openaire   +5 more sources

Tilting the balance between RNA interference and replication eradicates Leishmania RNA virus 1 and mitigates the inflammatory response. [PDF]

, 2016
Many Leishmania (Viannia) parasites harbor the double-stranded RNA virus Leishmania RNA virus 1 (LRV1), which has been associated with increased disease severity in animal models and humans and with drug treatment failures in humans.
Akopyants, N.S., Beverley, S.M., Brettmann, E.A., Fasel, N., Hickerson, S.M., Kuhlmann, F.M., Lye, L.F., Oschwald, D.M., Owens, K.L., Ronet, C., Shaik, J.S., Zangger, H.   +11 more
core   +2 more sources

Leishmaniasis in Bolivia: V. Human strains of Leishmania (V.) braziliensis from the Department of Pando [PDF]

Memórias do Instituto Oswaldo Cruz, 1989
Torres Espejo, Jose Miguel, Pratlong, Francine, Le Pont, François, Mouchet, Jean, Desjeux, Philippe, Rioux, Jean-Antoine   +5 more
openaire   +4 more sources

Unraveling the genetic diversity and phylogeny of Leishmania RNA virus 1 strains of infected Leishmania isolates circulating in French Guiana.

PLoS Neglected Tropical Diseases, 2017
IntroductionLeishmania RNA virus type 1 (LRV1) is an endosymbiont of some Leishmania (Vianna) species in South America. Presence of LRV1 in parasites exacerbates disease severity in animal models and humans, related to a disproportioned innate immune ...
Sourakhata Tirera, Marine Ginouves, Damien Donato, Ignacio S Caballero, Christiane Bouchier, Anne Lavergne, Eliane Bourreau, Emilie Mosnier, Vincent Vantilcke, Pierre Couppié, Ghislaine Prevot, Vincent Lacoste   +11 more
doaj   +1 more source

Clinical and Parasite Species Risk Factors for Pentavalent Antimonial Treatment Failure in Cutaneous Leishmaniasis in Peru [PDF]

, 2017
Background. Treatment for cutaneous leishmaniasis (CL) with standard pentavalent antimonial therapy is hampered by cumbersome administration, toxicity, and potential failure.
Araujo-Castillo, Roger, Arevalo, Jorge, Boelaert, Marleen, Chappuis, Francois, De Doncker, Simonne, Dujardin, Jean-Claude, Lazo, Marcela, Llanos-Cuentas, Alejandro, Miranda-Verastegui, Cesar, Ramirez, Luis, Robays, Jo, Santamaria-Castrellon, Giovanna, Tulliano, Gianfranco   +12 more
core