Results 81 to 90 of about 9,389 (214)

Pterocarpanquinone LQB-118 induces apoptosis in Leishmania (Viannia) braziliensis and controls lesions in infected hamsters. [PDF]

PLoS ONE, 2014
Previous results demonstrate that the hybrid synthetic pterocarpanquinone LQB-118 presents antileishmanial activity against Leishmania amazonensis in a mouse model.
Luciana Costa, Roberta O Pinheiro, Patrícia M L Dutra, Rosiane F Santos, Edézio F Cunha-Júnior, Eduardo C Torres-Santos, Alcides J M da Silva, Paulo R R Costa, Silvia A G Da-Silva   +8 more
doaj   +1 more source

Emerging Role for the PERK/eIF2α/ATF4 in Human Cutaneous Leishmaniasis. [PDF]

, 2017
Leishmania parasites utilize adaptive evasion mechanisms in infected macrophages to overcome host defenses and proliferate. We report here that the PERK/eIF2α/ATF4 signaling branch of the integrated endoplasmic reticulum stress response (IERSR) is ...
Aktas, B.H., Calegari-Silva, T.C., Cavalcanti, Á., Dias-Teixeira, K.L., Fasel, N., Gomes, C.M., Lopes, U.G., Medina, J.M., Pereira, RMS, Real, F., Santana, AKM, Silva, J.S., Teteo, N., Vivarini, Á.C.   +13 more
core   +3 more sources

World Association for Veterinary Dermatology Consensus Statement for Diagnosis, and Evidence‐Based Clinical Practice Guidelines for Treatment and Prevention of Canine Leishmaniosis

Veterinary Dermatology, Volume 36, Issue 6, Page 723-787, December 2025.
Hyperkeratosis of (a) the footpads and (b) the nasal planum. ABSTRACT Background Canine leishmaniosis (CanL) due to Leishmania infantum remains common, and veterinarians do not always follow scientifically sound approaches for diagnosis, treatment and prevention. Objectives To provide consensus guidelines for diagnosis and evidence‐based guidelines for
Manolis N. Saridomichelakis, Gad Baneth, Silvia Colombo, Filipe Dantas‐Torres, Lluís Ferrer, Alessandra Fondati, Guadalupe Miró, Laura Ordeix, Domenico Otranto, Chiara Noli   +9 more
wiley   +1 more source

Comparison of serological and parasitological methods for cutaneous leishmaniasis diagnosis in the state of Paraná, Brazil

Brazilian Journal of Infectious Diseases
We evaluated the effectiveness of serological and parasitological methods for cutaneous leishmaniasis (CL) diagnosis in patients from the central region of Paraná state, southern Brazil.
Regiane Szargiki, Edilene Alcântara de Castro, Ennio Luz, Wolodymir Kowalthuk, Ângela Maria Machado, Vanete Thomaz-Soccol   +5 more
doaj   +1 more source

New insights into the genetic diversity of Leishmania RNA Virus 1 and its species-specific relationship with Leishmania parasites. [PDF]

PLoS ONE, 2018
Cutaneous leishmaniasis is a neglected parasitic disease that manifests in infected individuals under different phenotypes, with a range of factors contributing to its broad clinical spectrum. One factor, Leishmania RNA Virus 1 (LRV1), has been described
Lilian Motta Cantanhêde, Flavia Gonçalves Fernandes, Gabriel Eduardo Melim Ferreira, Renato Porrozzi, Ricardo de Godoi Mattos Ferreira, Elisa Cupolillo   +5 more
doaj   +1 more source

Going Mobile: Using Portable Genomic Technologies for PCR‐Free In Situ Species Identification and Real‐Time Molecular Systematics

Ecology and Evolution, Volume 15, Issue 11, November 2025.
Here, we document how the implementation of a portable laboratory, in combination with targeted long‐read sequencing through an approach known as nanopore adaptive sampling, can facilitate in situ genomic and systematic analyses across a wide range of animal taxa, including multiple small mammals and blood‐feeding arthropods.
Evan J. Kipp, Marissa S. Milstein, Lexi E. Frank, Roxanne J. Larsen, Tiffany M. Wolf, Christopher Faulk, Christopher A. Shaffer, Peter A. Larsen   +7 more
wiley   +1 more source

PCR-RFLP analyses of Leishmania species causing cutaneous and mucocutaneous leishmaniasis revealed distribution of genetically complex strains with hybrid and mito-nuclear discordance in Ecuador.

PLoS Neglected Tropical Diseases, 2019
PCR-Restriction Fragment Length Polymorphism (RFLP) analyses targeting multiple nuclear genes were established for the simple and practical identification of Leishmania species without using expensive equipment.
Hirotomo Kato, Eduardo A Gomez, Chisato Seki, Hayato Furumoto, Luiggi Martini-Robles, Jenny Muzzio, Manuel Calvopiña, Lenin Velez, Makoto Kubo, Ahmed Tabbabi, Daisuke S Yamamoto, Yoshihisa Hashiguchi   +11 more
doaj   +1 more source

Leishmania-specific surface antigens show sub-genus sequence variation and immune recognition. [PDF]

, 2010
A family of hydrophilic acylated surface (HASP) proteins, containing extensive and variant amino acid repeats, is expressed at the plasma membrane in infective extracellular (metacyclic) and intracellular (amastigote) stages of Old World Leishmania ...
Depledge, DP, Hodgkinson, MR, Jackson, AP, Ma, S, MacLean, LM, Smith, BA, Smith, DF, Uliana, SR   +7 more
core  

Complete Resolution of Cutaneous Leishmaniasis With a Novel Topical Combination Therapy: A Case Series

Clinical Case Reports, Volume 13, Issue 10, October 2025.
ABSTRACT Cutaneous leishmaniasis (CL) remains a therapeutic challenge in endemic regions, with 600,000–1 million new cases annually facing limited treatment options. We present a case series evaluating an innovative topical combination therapy for acute‐phase CL in Shiraz, Iran.
Hoda Haghshenas, Aref Ghanaatpisheh, Mohammad Darayesh, Elaheh Entezar Almahdi   +3 more
wiley   +1 more source

Ethnomedicinal Uses, Phytochemistry, Pharmacological Activities, and Toxicology of the Subfamily Gomphrenoideae (Amaranthaceae): A Comprehensive Review

Chemistry &Biodiversity, Volume 22, Issue 9, September 2025.
ABSTRACT The subfamily Gomphrenoideae is composed of about 480 accepted species, many of which have been historically used as medicinal plants, reason why they have been studied in terms of chemical profile, biological activity, and safety. This review consolidates the advances in research on this subfamily over the past 47 years, emphasizing its ...
Dayanna Isabel Araque Gelves, Giulia Cristina de Andreoli Souza, Alvaro Jose Hernandez Tasco, Marcos José Salvador   +3 more
wiley   +1 more source