Results 91 to 100 of about 11,204 (214)

Leishmania naiffi and Leishmania guyanensis reference genomes highlight genome structure and gene evolution in the Viannia subgenus [PDF]

Royal Society Open Science, 2018
The unicellular protozoan parasite Leishmania causes the neglected tropical disease leishmaniasis, affecting 12 million people in 98 countries. In South America, where the Viannia subgenus predominates, so far only L. (Viannia) braziliensis and L.
Simone Coughlan, Ali Shirley Taylor, Eoghan Feane, Mandy Sanders, Gabriele Schonian, James A. Cotton, Tim Downing   +6 more
doaj   +1 more source

Geographic Distribution of Leishmania Species in Ecuador Based on the Cytochrome B Gene Sequence Analysis. [PDF]

PLoS Neglected Tropical Diseases, 2016
A countrywide epidemiological study was performed to elucidate the current geographic distribution of causative species of cutaneous leishmaniasis (CL) in Ecuador by using FTA card-spotted samples and smear slides as DNA sources.
Hirotomo Kato, Eduardo A Gomez, Luiggi Martini-Robles, Jenny Muzzio, Lenin Velez, Manuel Calvopiña, Daniel Romero-Alvarez, Tatsuyuki Mimori, Hiroshi Uezato, Yoshihisa Hashiguchi   +9 more
doaj   +1 more source

Leishmania-specific surface antigens show sub-genus sequence variation and immune recognition. [PDF]

, 2010
A family of hydrophilic acylated surface (HASP) proteins, containing extensive and variant amino acid repeats, is expressed at the plasma membrane in infective extracellular (metacyclic) and intracellular (amastigote) stages of Old World Leishmania ...
Depledge, DP, Hodgkinson, MR, Jackson, AP, Ma, S, MacLean, LM, Smith, BA, Smith, DF, Uliana, SR   +7 more
core  

Testing of four Leishmania vaccine candidates in a mouse model of infection with Leishmania (Viannia) braziliensis, the main causative agent of cutaneous leishmaniasis in the new world [PDF]

, 2007
We evaluated whether four recombinant antigens previously used for vaccination against experimental infection with Leishmania (Leishmania) major could also induce protective immunity against a challenge with Leishmania (Viannia) braziliensis, the species
Ba Brazil, C. Brodskyn, C. I. Oliveira, C. L. Barbiéri, G. Salay, M. L. Dorta, M. M. Rodrigues, N. M. Santos, R. A. Mortara   +8 more
core   +3 more sources

In Situ Evaluation of Macrophage Populations and Inflammasome Components in Cutaneous and Mucocutaneous Leishmaniasis

Parasite Immunology, Volume 47, Issue 9, September 2025.
ABSTRACT American tegumentary leishmaniasis (ATL) affects the skin and mucous membranes, with a spectrum shaped by Th1/Th2 responses. This study investigated inflammasome activation in correlation with macrophage subpopulations, tissue parasitism, and histological changes in cutaneous and mucocutaneous leishmaniasis. We assessed inflammasome activation,
Caroline de Heleno Chagas de Carvalho, Gabriela Venicia Araujo Flores, Carmen Maria Sandoval Pacheco, Vania Lucia da Ribeiro da Matta, Carolina de Esteves de Morais, Ricardo Romiti, Walter Belda Júnior, Márcia Dalastra Laurenti   +7 more
wiley   +1 more source

Influence of Leishmania (Viannia) Species on the Response to Antimonial Treatment in Patients with American Tegumentary Leishmaniasis [PDF]

, 2017
Background. Pentavalent antimonials (SbV) are the first-line chemotherapy for American tegumentary leishmaniasis (ATL). There are, however, reports of the occurrence of treatment failure with these drugs.
Adaui, Vanessa, Arevalo, Jorge, Chappuis, Francois, De Doncker, Simonne, Dujardin, Jean-Claude, Lazo, Marcela, Llanos-Cuentas, Alejandro, Loayza-Muro, Raúl, Maurer, Anne, Miranda-Verástegui, César, Ramirez, Luis, Tulliano, Gianfranco, Zimic, Mirko   +12 more
core  

Influência da idade sobre o prognóstico da leishmaniose cutânea tratada com antimonial pentavalente em área de transmissão de Leishmania (Viannia) braziliensis [PDF]

, 2016
Dissertação (mestrado)—Universidade de Brasília, Faculdade de Medicina, Pós-graduação em Medicina Tropical, 2016.Os antimoniais pentavalentes continuam como primeira opção para o tratamento da leishmaniose cutânea (LC) em crianças e adultos no Brasil ...
Morato Filho, Getúlio Bernardo
core   +1 more source

Antileishmanial Activities of Methanol Extract and Solvent Fraction of Clematis simensis Fresen Roots

Advances in Pharmacological and Pharmaceutical Sciences, Volume 2025, Issue 1, 2025.
Background Leishmaniasis is a neglected tropical disease affecting 12 million people and risks the lives of 350 million people globally. However, it has limited therapeutic options. Clematis simensis Fresen roots are used for the treatment of leishmaniasis in Ethiopian traditional medicine. Objective The aim of this study was to evaluate C.
Amare Megersa, Aschalew Nardos, Tasisa Ketema, Serawit Deyno, Srinivas Mutalik   +4 more
wiley   +1 more source

Putative markers of infective life stages in Leishmania (Viannia) braziliensis

Parasitology, 2007
SUMMARYGene expression is known to vary significantly during the Leishmania life-cycle. Its monitoring might allow identification of molecular changes associated with the infective stages (metacyclics and amastigotes) and contribute to the understanding of the complex host-parasite relationships.
Gamboa, D., Van Eys, G., Victoir, K., Torres, K., Adaui, V., Arevalo, J., Dujardin, J. C.   +6 more
openaire   +4 more sources

Leishmaniose cutânea acidental Accidental cutaneous leishmaniasis

Revista do Instituto de Medicina Tropical de São Paulo, 1993
Os autores relatam o 3º caso de Leishmaniose acidental em laboratório, ocorrido em aluna do curso de Biologia, que contaminou-se por ocasião da passagem de formas amastigotas de Leishmania (Viannia) braziliensis de hamster infectado para hamster são ...
Neuza Lima Dillon, Hamilton Ometto Stolf, Elizaide L. Alvarenga Yoshida, Mariangela E. Alencar Marques   +3 more
doaj   +1 more source