Results 61 to 70 of about 208,963 (249)

Efficient and Rapid Arylation of NH₂‐Unprotected Bromobisindole Ethanamines via Suzuki‐Miyaura Coupling: Generating New Leads Against Leishmania

Chemistry – A European Journal, EarlyView.
A library of novel bisindole derivatives was synthesized through an optimized rapid Suzuki‐Miyaura coupling reaction, utilizing NH2‐unprotected bromobisindole ethanamines and boronic acids with yields up to 93%. The compounds were screened for their activity against L. infantum promastigotes.
Alessandro Buono, Aurora Diotallevi, Sara Maestrini, Michele Verboni, Paula Kiuru, Luca Galluzzi, Andrea Duranti, Diego Olivieri, Simone Lucarini   +8 more
wiley   +1 more source

Leishmaniasis visceral: senderos que confluyen, se bifurcan

, 2012
La leishmaniasis visceral urbana es una zoonosis emergente en Argentina. En America es producida por Leishmania infantum, con el perro como reservorio principal e insectos flebotomineos como vectores.
Óscar Daniel, A. Verónica, María, Soledad, Silvina, Tomas, Ángel, Concepción, Adelina, Natalia, Paola   +10 more
semanticscholar   +2 more sources

TLR4 and TLR9 polymorphism: Probable role in susceptibility among the population of Bihar for Indian visceral leishmaniasis

Innate Immunity, 2021
Genetic variations in the host TLRs genes play an important role in susceptibility and/or resistance to visceral leishmaniasis by altering the host-pathogen interaction.
Abhishek Mandal, Manish Kumar, Ashish Kumar, Abhik Sen, Pradeep Das, Sushmita Das   +5 more
doaj   +1 more source

Insights on adaptive and innate immunity in canine leishmaniosis [PDF]

, 2016
Canine leishmaniosis (CanL) is caused by the parasite Leishmania infantum and is a systemic disease, which can present with variable clinical signs, and clinicopathological abnormalities.
Abi Abdallah, Alexander, Catchpole, DAMER P. BLAKE, de Souza Carmo, Green, Kensil, LAIA SOLANO-GALLEGO, Lopez, Margarito, Ordeix, Pinelli, Pitta, Quinnell, Sadick, Sanchez, SHAZIA HOSEIN, Silva, Vouldoukis, Wakelin   +19 more
core   +3 more sources

Antiprotozoal activity of highly substituted pyrazole and pyrimidine derivates

ChemMedChem, Accepted Article.
To further extend the structure‐activity relationships of previously reported antimalarial anilino‐pyrazoles VI, trisubstituted pyrazoles 13‐15 and pyrimidines 16 and 17 were designed and synthesized. The novel derivatives were prepared thorough a divergent, chemo‐selective approach starting from N,S‐acetal intermediates.
Matteo Lusardi, Nicoletta Basilico, Erika Iervasi, Chiara Brullo, Silvia Parapini, Marco Ponassi, Camillo Rosano, Andrea Spallarossa   +7 more
wiley   +1 more source

Geographic distribution and spatial analysis of Leishmania infantum infection in domestic and wild animal reservoir hosts of zoonotic visceral leishmaniasis in Iran: A systematic review

Journal of Vector Borne Diseases, 2018
Visceral leishmaniasis (VL) is an important parasitic disease which is endemic in different parts of Iran; and domestic and wild canines are principal reservoir hosts of the disease.
M. Mohebali, E. Moradi-Asl, Y. Rassi
semanticscholar   +1 more source

Key Regulators of Parasite Biology Viewed Through a Post‐Translational Modification Repertoire

PROTEOMICS, EarlyView.
ABSTRACT Parasites are the leading causes of morbidity and mortality in both humans and animals, imposing substantial socioeconomic burdens worldwide. Controlling parasitic diseases has become one of the key issues in achieving “One Health”. Most parasites have sophisticated life cycles exhibiting progressive developmental stages, morphologies, and ...
Naiwen Zhang, Ning Jiang, Qijun Chen
wiley   +1 more source

Epidemiology of Visceral Leishmaniasis in Georgia [PDF]

PLoS Neglected Tropical Diseases, 2014
This study investigated the transmission and prevalence of Leishmania parasite infection of humans in two foci of Visceral Leishmaniasis (VL) in Georgia, the well known focus in Tbilisi in the East, and in Kutaisi, a new focus in the West of the country.
Babuadze, Giorgi, Alvar, Jorge, Argaw, Daniel, de Koning, Harry P., Iosava, Merab, Kekelidze, Merab, Tsertsvadze, Nikoloz, Tsereteli, David, Chakhunashvili, Giorgi, Mamatsashvili, Tamar, Beria, Nino, Kalandadze, Irine, Ejov, Mikhail, Imnadze, Paata   +13 more
openaire   +5 more sources

Low castes have poor access to visceral leishmaniasis treatment in Bihar, India [PDF]

, 2012
Objectives  Bihar, the poorest state in India, concentrates most of the visceral leishmaniasis (VL) cases in the country. A large proportion of the poor rural communities where VL is endemic are marginalized by their socio-economic status, intrinsically ...
Alvar, Babu, Barratt, Boelaert, Cerf, Collin, de Onis, Dedet, Desjeux, Dye, Hasker, Heymann, India., G.o, Mondal, Ostyn, Ranjan, Sinha, Thakur, Van de Poel, WHO, WHO, WHO, WHO/UNICEF   +22 more
core   +2 more sources

Histological Disorganization of Spleen Compartments and Severe Visceral Leishmaniasis

Frontiers in Cellular and Infection Microbiology, 2018
The spleen is a secondary lymphoid organ responsible for immune surveillance against blood-circulating pathogens. Absence of the spleen is associated with increased susceptibility to systemic spread and fatal infection by different pathogens.
M. D. Hermida, C. V. B. de Melo, I. Lima, G. G. Oliveira, W. dos-Santos   +4 more
semanticscholar   +1 more source