Results 61 to 70 of about 47,632 (221)

Bidirectional Interaction Between Liposomal Amphotericin B Pharmacokinetics and Parasite Dynamics in Patients With Post‐Kala‐Azar Dermal Leishmaniasis: Potential Implications for Optimal Dosing

Clinical Pharmacology &Therapeutics, Volume 119, Issue 2, Page 437-446, February 2026.
Post‐kala‐azar dermal leishmaniasis (PKDL) involves a high macrophage burden in which the Leishmania parasites reside. Liposomal amphotericin B (LAmB) plays a key role in the treatment of PKDL. The mononuclear phagocyte system (MPS) is crucial in the distribution of liposomal drugs as well as the leishmaniasis pathophysiology.
Wan‐Yu Chu, Om Prakash Singh, Shyam Sundar, Dinesh Mondal, Krishna Pandey, Pradeep Das, Ignace C. Roseboom, Sheeraz Raja, Ana Torres, Eugenia Carrillo, Alwin D.R. Huitema, Fabiana Alves, Thomas P.C. Dorlo   +12 more
wiley   +1 more source

Cortisol Regulates PD‐1 and IL‐12 in Canine Leishmaniasis

Parasite Immunology, Volume 48, Issue 2, February 2026.
ABSTRACT Canine visceral leishmaniasis (CanL) is a tropical zoonosis caused by Brazil's protozoan Leishmania (L.) infantum. Disorders in the hypothalamic–pituitary–adrenal (HPA) axis have been reported in human and experimental visceral leishmaniasis, but not yet in canine leishmaniasis.
Lucas Takeshi Siqueira Ito, Gisele Mitsue Umino, Mayla Abbas Guimarães, Bianca Maciel Marques de Souza, Sofia Furrier Soares, Luiz Eduardo Amador Loiola Pereira, Valéria Marçal Felix de Lima   +6 more
wiley   +1 more source

Urine as a promising sample for Leishmania DNA extraction in the diagnosis of visceral leishmaniasis – a review

Brazilian Journal of Infectious Diseases, 2019
Visceral leishmaniasis is a serious and debilitating infection with high fatality rate in tropical and subtropical countries. As clinical symptoms of visceral leishmaniasis are not so specific, confirmatory diagnostic methods with high sensitivity and ...
Gilberto Silva Nunes Bezerra, Walter Lins Barbosa, Júnior, Elis Dionísio da Silva, Nilma Cintra Leal, Zulma Maria de Medeiros   +4 more
doaj   +1 more source

A case report on para-kala-azar dermal leishmaniasis: an unresolved mystery

BMC Infectious Diseases, 2023
Background Post-kala-azar dermal leishmaniasis (PKDL) is a dermatosis that occurs 2–3 years after an apparently successful treatment of visceral leishmaniasis (VL).
Md. Mehedi Hasan, Sanghita Banik Proma, Md. Saddam Hossain, Md. Arifuzzaman, Naylla Islam, Md. Abu Bakar Siddique, Amiruzzaman   +6 more
doaj   +1 more source

Biomaterial Strategies for Targeted Intracellular Delivery to Phagocytes

Advanced Functional Materials, Volume 36, Issue 1, 2 January 2026.
Phagocytes are essential to a functional immune system, and their behavior defines disease outcomes. Engineered particles offer a strategic opportunity to target phagocytes, harnessing inflammatory modulation in disease. By tuning features like size, shape, and surface, these systems can modulate immune responses and improve targeted treatment for a ...
Kaitlyn E. Woodworth, Neal I. Callaghan, Locke Davenport Huyer   +2 more
wiley   +1 more source

Leishmaniasis–HIV coinfection: current challenges

HIV/AIDS: Research and Palliative Care, 2016
José Angelo Lauletta Lindoso,1,2 Mirella Alves Cunha,3 Igor Thiago Queiroz,4 Carlos Henrique Valente Moreira2 1Laboratory of Soroepidemiology (LIM HC-FMUSP), São Paulo University, São Paulo, 2Instituto de Infectologia Emilio ...
Lindoso JAL, Cunha MA, Queiroz IT, Moreira CHV   +3 more
doaj  

Advances in leishmaniasis.

, 2005
Governed by parasite and host factors and immunoinflammatory responses, the clinical spectrum of leishmaniasis encompasses subclinical (inapparent), localised (skin lesions), and disseminated infection (cutaneous, mucosal, or visceral).
Berman, Jonathan D, Davies, Clive R, Murray, Henry W, Saravia, Nancy G   +3 more
core   +1 more source

Unveiling the Leishmanicidal Mechanism of 4‐Nerolidylcatechol Isolated From Piper peltatum Against Leishmania infantum

Chemistry &Biodiversity, Volume 23, Issue 1, January 2026.
ABSTRACT The present study assessed the leishmanicidal activity of 4‐nerolidylcatechol (4‐NC) (1) isolated from Piper peltatum leaves against promastigotes and amastigotes of Leishmania amazonensis, L. braziliensis, and L. infantum. The plant was fractionated, leading to the isolation and chemical identification of 4‐NC (1). Biochemical techniques were
Fabiana Brusco Lorenzetti, Rodolfo Bento Balbinot, Danielle Lazarin‐Bidóia, Viviane dos Santos Faiões, Eduardo Caio Torres‐Santos, Celso Vataru Nakamura, Tânia Ueda‐Nakamura, Diógenes Aparício Garcia Cortez, Benedito Prado Dias Filho   +8 more
wiley   +1 more source

Epidemiological aspects of human and canine visceral leishmaniasis in State of Alagoas, Northeast, Brazil

Brazilian Journal of Biology, 2018
Zoonotic visceral leishmaniasis (ZVL), caused by protozoans of the genus Leishmania, it is a worldwide of great importance disease. In the northeast region of Brazil, the state of Alagoas has an endemic status for ZVL.
M. A. N. Rocha, T. J. Matos-Rocha, C. M. B. Ribeiro, S. R. O. Abreu   +3 more
doaj   +1 more source

The epidemiology of canine leishmaniasis: transmission rates estimated from a cohort study in Amazonian Brazil [PDF]

, 1997
We estimate the incidence rate, serological conversion rate and basic case reproduction number (R0) of Leishmania infantum from a cohort study of 126 domestic dogs exposed to natural infection rates over 2 years on Marajó Island, Pará State, Brazil.
Courtenay, O., Dye, C., Garcez, L.M., Quinnell, R.J.   +3 more
core   +1 more source