Results 81 to 90 of about 109,637 (271)

Disseminated perforating necrobiosis lipoidica: A case report and literature review

Clinical Case Reports, 2023
Key Clinical Message Necrobiosis lipoidica is a rare cutaneous granulomatous disease that mainly affects diabetic patients. The perforating type of the disease is an uncommon variant that is resistant to therapy and can be easily identified using ...
Mina Saber, Fatemeh Mohaghegh, Parisa Mohammadian   +2 more
doaj   +1 more source

Integrative proteomic analysis provides novel therapeutic insights for etiological subtypes of diabetes

Diabetes, Obesity and Metabolism, EarlyView.
Abstract Aims Type 2 diabetes (T2D) is a highly heterogeneous disease characterised by subtypes with variations in aetiology, disease progression, and risk of complications. However, potential drug targets for these subtypes have not been explored. This study aims to investigate potential drug targets by integrating proteomics.
Jiahe Wei, Hanzhang Wu, Ningjian Wang, Jiahao Zhu, Ranjit Mohan Anjana, Aleksandr V. Sokolov, Helgi B. Schiöth, Viswanathan Mohan, Xiao Tan   +8 more
wiley   +1 more source

Identification of CβS and ODC antimony resistance markers in anthroponotic cutaneous leishmaniasis field isolates by gene expression profiling

Parasite Epidemiology and Control
Antiparasitic resistance represents a serious global public health concern with tremendous economic and safety implications. This study intended to investigate the expression of the two major resistant markers: cystathionine β synthase (CβS) and ...
Farzaneh Zarrinkar, Iraj Sharifi, Razieh Tavakoli Oliaee, Ali Afgar, Elaheh Molaakbari, Mehdi Bamorovat, Zahra Babaei, Ebrahim Eskandari, Ehsan Salarkia, Marzieh Asadi   +9 more
doaj   +1 more source

Clinical and Epidemiological Features of Patients with Drug-Induced Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in Iran: Different Points of Children from Adults

International Journal of Pediatrics, 2022
Background. Different epidemiologic aspects of drug-induced Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) in children are scarce. Aim. To compare the clinical and epidemiological features of patients with drug-induced SJS and TEN in
Bahareh Abtahi-Naeini, Mohammad-sadegh Dehghan, Fatemeh Paknazar, Zabihollah Shahmoradi, Gita Faghihi, Ali Mohammad Sabzghabaee, Mojtaba Akbari, Mahdi Hadian, Tooba Momen   +8 more
doaj   +1 more source

Evolutionary divergence and functional insights into the heteromeric cis‐prenyltransferase of Paramecium tetraurelia

The FEBS Journal, EarlyView.
Heteromeric cis‐prenyltransferases (CPT) are indispensable for dolichol synthesis and protein N‐glycosylation in most eukaryotes. The catalytic subunits are strongly conserved throughout evolution, in contrast to the evolutionarily variable accessory subunits. The POC1 protein from Paramecium tetraurelia is the smallest identified CPT‐accessory subunit
Agnieszka Onysk, Kamil Steczkiewicz, Mariusz Radkiewicz, Paweł Link‐Lenczowski, Przemysław Surowiecki, Karolina Sztompka, Kariona A. Grabińska, Jacek K. Nowak, Liliana Surmacz   +8 more
wiley   +1 more source

Cutaneous Leishmaniasis

The Moldovan Medical Journal, 2018
Background: Leishmaniasis is a disease caused by parasites of the Leishmania type. Cutaneous leishmaniasis (CL) is a neglected worldwide, zoonotic, vector-borne, tropical disease. The clinical spectrum of leishmaniasis ranges from a self-resolving cutaneous ulcer to a mutilating mucocutaneous disease and even to a lethal systemic illness.
Placinta, Gheorghe, Pantea, Victor, Cebotarescu, Valentin, Cojuhari, Lilia, Paveliuc, Petru, Musteata, Tatiana, Panasiuc, Alexandru, Lungu, Victoria, Simonov, Ludmila   +8 more
openaire   +3 more sources

Evaluation of fluorimetry and direct visualization to interpret results of a loop-mediated isothermal amplification kit to detect Leishmania DNA

Parasites & Vectors, 2018
Background Nucleic acid amplification tests (NAATs) have proven to be advantageous in the diagnosis of leishmaniases, allowing sensitive diagnosis of: (i) cutaneous leishmaniasis in long duration lesions and (ii) visceral leishmaniasis using a less ...
Ana V. Ibarra-Meneses, Israel Cruz, Carmen Chicharro, Carmen Sánchez, Sylvain Biéler, Tobias Broger, Javier Moreno, Eugenia Carrillo   +7 more
doaj   +1 more source

Macrophage Polarization in Leishmaniasis: Broadening Horizons

Frontiers in Immunology, 2018
Leishmaniasis is a vector-borne neglected tropical disease that affects more than 700,000 people annually. Leishmania parasites cause the disease, and different species trigger a distinct immune response and clinical manifestations.
Fernanda Tomiotto-Pellissier, B. Bortoleti, J. P. Assolini, M. D. Gonçalves, A. Carloto, M. M. Miranda-Sapla, I. Conchon-Costa, J. Bordignon, W. Pavanelli   +8 more
semanticscholar   +1 more source

Major revision version 13.0 of the European AIDS Clinical Society guidelines 2025

HIV Medicine, EarlyView.
Abstract Background The European AIDS Clinical Society (EACS) guidelines were revised for the 21st time in 2025, with updates covering all aspects of HIV care. Key Points of the Guidelines Update The structure of the guidelines has been reorganized into two parts: Part I focuses on the management and prevention of HIV and related infections, and Part ...
Juan Ambrosioni, Laura I. Levi, Jasmini Alagaratnam, Abiu Sempere, Andrea Mastrangelo, Paolo Paioni, Cristina Mussini, Catia Marzolini, Susanne Dam Nielsen, Charles Béguelin, Steven Welch, Anna Koval, Luis Mendao, Alasdair Bamford, Alexandra Calmy, Giovanni Guaraldi, Cristiana Oprea, Esteban Martínez, Jürgen K. Rockstroh, The EACS Governing Board   +19 more
wiley   +1 more source

Diagnosis of leishmaniasis

The Journal of Infection in Developing Countries, 2014
Leishmaniasis is a clinically heterogeneous syndrome caused by intracellular protozoan parasites of the genus Leishmania. The clinical spectrum of leishmaniasis encompasses subclinical ( not apparent), localized (skin lesion), and disseminated (cutaneous, mucocutaneous, and visceral) infection.
Ehab Kotb Elmahallawy, Antonio Sampedro Martínez, Javier Rodríguez‐Granger, Yannick Hoyos-Mallecot, Ahmad Agil, José María Navarro‐Marí, José Gutiérrez Fernández   +6 more
openaire   +6 more sources