Results 111 to 120 of about 2,246,388 (261)
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Length-dependent survival probability pooled over hauls.
, 2016 Circles represent experimentally observed survival probabilities. Thick solid line represents the modelled length-dependent survival rate at the end of the observation period.
Ludvig A. Krag (612072) +5 more
core +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Length-response curves of different neurons.
, 2018 The top plot depicts the modulus of the eigenvector corresponding to eigenfrequency ω = 1.92. The 4 panels below are plots of the length-response curves for 4 different neurons in the network.
Keith Hayton (5150327) +2 more
core +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
On the Term ‘Qita’ in Turkish Tezkires of the 16th–19th cc.
Oriental Studies, 2018 This article attempts to describe how the authors of Turkish tezkires of the 16th–19th centuries interpreted the term ‘qita’ and to trace changes of the term during the mentioned period.
Anastasia Semina
doaj +1 more source
Length-weight parameters in West Africa for Sardinella maderensis.
, 2016 The length is expressed as fork length.
Alioune Faye (2825966) +10 more
core +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Journal of Pharmacy and Bioallied SciencesThis present study has the purpose of determining how surface topography of implants affects the initial stability of miniscrew implants (MSIs). Electronic databases like PubMed Central, Scopus, Web of Science, Embase, and Cochrane Library, as well as ...
Shivani Singh +5 more
doaj +1 more source
PLANCK LENGTH AND COSMOLOGY [PDF]
Modern Physics Letters A, 2007 We show that an unification of quantum mechanics and general relativity implies that there is a fundamental length in Nature in the sense that no operational procedure would be able to measure distances shorter than the Planck length. Furthermore we give an explicit realization of an old proposal by Anderson and Finkelstein who argued that a ...
openaire +3 more sources