Results 61 to 70 of about 11,049,885 (285)

The relationship between the PICC tip position and weight gain, length growth of premature infants under ultrasonography: a correlation analysis study

Frontiers in Medicine, 2023
ObjectiveThis study aimed to analyze the correlation between PICC tip position and weight/length changes in preterm infants in different positions using ultrasonography.MethodsThe study is a prospective before and after self-control clinical trial.
Xiaojun Tao, Xianhong Zhang, Jianhui Wang, Yanhan Chen, Xuexiu Liu   +4 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

NONO, SFPQ, and PSPC1 promote telomerase recruitment to the telomere

Nature Communications
Telomerase is a ribonucleoprotein enzyme that maintains telomeric repeats on chromosome ends in continuously dividing cells. Telomere maintenance via telomerase is dependent on the correct assembly of the enzyme complex, complex stabilization by ...
Alexander P. Sobinoff, Jadon K. Wells, Maurice Chow, Christopher B. Nelson, Xinyi Wu, Scott B. Cohen, Yu Heng Lau, Tracy M. Bryan, Archa Fox, Hilda A. Pickett   +9 more
doaj   +1 more source

Reduction of oxygen content in laser powder bed fusion process atmosphere – Effects on stochastic defect formation and mechanical properties

Journal of Materials Research and Technology
Stochastic defects in materials manufactured via laser powder bed fusion (LPBF) can severely compromise mechanical performance and are challenging to predict and detect, thus motivating the development of defect mitigation strategies.
Claudia Schwerz, Johan Moverare, Alain Kung, Benjamin A. Bircher, Dmitri Riabov, Lars Nyborg   +5 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

DNA methylation and telomere length in 2–5 year olds with intrauterine preeclampsia exposure: a P4 sub-study

Clinical Epigenetics
Preeclampsia is a hypertensive disorder of pregnancy characterised by new onset hypertension at ≥ 20 weeks’ gestation accompanied by maternal organ dysfunction and/ or fetal compromise.
Jason P. Ross, Benjamin J. Varley, Jadon K. Wells, Robyn P. L. Yeh, Hilda A. Pickett, Raja S. Vasireddy, Lynne Roberts, Greg Davis, Amanda Henry, Maria E. Craig, Megan L. Gow   +10 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Mechanical properties of Hastelloy X produced by laser powder bed fusion and affected by spatter redeposition

Journal of Materials Research and Technology
Defects in materials manufactured via laser powder bed fusion challenge this manufacturing process' dependability and may prevent it from being comprehensively used for structural components, particularly those intended to operate under dynamic loading ...
Claudia Schwerz, Johan Moverare, Vishal Sundar, Benjamin A. Bircher, Alain Küng, Dmitri Riabov, Lars Nyborg   +6 more
doaj   +1 more source

Length functions of Hitchin representations

, 2013
Given a Hitchin representation $\rho \colon \pi_1(S) \to \PSL_n(\mathbb{R})$, we construct $n$ continuous functions $\ell_i^\rho \colon \mathcal \CH(S) \to \mathbb{R}$ defined on the space of H\"older geodesic currents $\CH(S)$ such that, for a closed ...
Bridson, Fathi, Ghys, Gromov, Guichard, Guillaume Dreyer, Margulis, Penner   +7 more
core   +1 more source