Results 71 to 80 of about 11,049,885 (285)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Bounding the homological finiteness length
, 2012 We give a criterion for bounding the homological finiteness length of certain HF-groups. This is used in two distinct contexts. Firstly, the homological finiteness length of a non-uniform lattice on a locally finite n-dimensional contractible CW-complex ...
Gandini, Giovanni
core +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
Length Functions for Semigroup Embeddings [PDF]
, 2010 Following the work done by Olshanskii for groups, we describe, for a given semigroup $S$, which functions $l : S \rightarrow \mathbb{N}$ can be realized up to equivalence as length functions $g \mapsto |g|_{H}$ by embedding $S$ into a finitely generated ...
Davis, Tara
core +2 more sources
Canonical transformations and minimal length
, 2015 We show how to modify the canonical transformations to make them compatible with non-commutative Poisson brackets.Comment: 11 pages, no ...
Valtancoli, P.
core +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Study of the Variability of the Physical and Mechanical Properties of Chinchilla Hair
Journal of Natural FibersThis study investigates the physical and mechanical properties of Chinchilla hair, renowned for their softness, warmth, and lightweight qualities, obtained from Chinchilla rodents. The exploration of Chinchilla hair’s textile potential remains relatively
Wafa Mahjoub +3 more
doaj +1 more source
Minimal Length, Measurability and Gravity
, 2016 The present work is a continuation of the previous papers written by the author on the subject. In terms of the measurability (or measurable quantities) notion introduced in a minimal length theory, first the consideration is given to a quantum theory in
Shalyt-Margolin, A. E.
core +2 more sources