Results 61 to 70 of about 1,834,359 (305)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Newborn Length of Stay and Risk of Readmission. [PDF]

, 2017
BACKGROUND: Evidence on the association between newborn length of hospital stay (LOS) and risk of readmission is conflicting. We compared methods for modelling this relationship, by gestational age, using population-level hospital data on births in ...
Cromwell, David, Gilbert, Ruth, Harron, Katie, Oddie, Sam, van der Meulen, Jan   +4 more
core   +2 more sources

Decreasing Length of Stay After Pancreatoduodenectomy [PDF]

Archives of Surgery, 2000
Decreased length of stay (LOS) after pancreatoduodenectomy is due to multiple factors, including a lower complication rate and more efficient perioperative care for all patients, with and without complications.A retrospective review, validation cohort.A single university hospital referral center.A consecutive sample of patients undergoing ...
A D, Brooks, S G, Marcus, C, Gradek, E, Newman, P, Shamamian, T H, Gouge, H L, Pachter, K, Eng   +7 more
openaire   +2 more sources

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Duration of Hospitalization in Association with Type of Inhalation Therapy Used in the Management of Children with Nonsevere, Acute Bronchiolitis

Pediatrics and Neonatology, 2016
Acute bronchiolitis is one of the main respiratory emergencies in young children. Although supportive therapy is recommended, substantial inconsistency in the clinical usage of inhaled treatments has been reported.
Jamie M. Pinto, Janet L. Schairer, Anna Petrova   +2 more
doaj   +1 more source

Internal Medicine [PDF]

, 2017
Our objective was to develop a model to predict the length of stay of patients using data from MCV. We conducted our analysis using a dataset of over 130,000 patients described by 66 features.
Hakem, Keroles, Trachy, Robert, Tran, Khanh   +2 more
core   +1 more source

Determinant factors of senior tourists’ length of stay [PDF]

, 2014
The current tendency to undertake more trips, but of shorter duration, throughout the year, has meant that the tourist industry has started to show greater interest in attracting those market segments that opt for more prolonged stays, as they are ...
Alén, Elisa, Domínguez, Trinidad, Losada, Nieves, Nicolau, Juan Luis   +3 more
core   +2 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Determining factors influencing hospital stay for individuals admitted with diabetes-related ketoacidosis – findings from DEKODE length of stay quality improvement project

Clinical Medicine
There are significant variations in discharge post-diabetes-related ketoacidosis (DKA) hospitalisation, yet there is a paucity of research to understand or minimise the reasons.
Ankita Gupta, Benedict Brazier, Lakshmi Rengarajan, Parth Narendran, Punith Kempegowda   +4 more
doaj   +1 more source

Length of Stay After Childbirth in 92 Countries and Associated Factors in 30 Low- and Middle-Income Countries: Compilation of Reported Data and a Cross-sectional Analysis from Nationally Representative Surveys [PDF]

, 2016
Background: Following childbirth, women need to stay sufficiently long in health facilities to receive adequate care. Little is known about length of stay following childbirth in low- and middle-income countries or its determinants.
B Chalmers, C Catz, CK Stanton, CK Stanton, D Bowser, David Macleod, DS Seidman, E Declercq, E Kulinskaya, E Schorr, FA Chervenak, J Martines, J Novak, J Rush, JD Malkin, Jenny E Myers, JL Hintze, JR Britton, L Benova, L Kumbani, Lenka Benova, LM Hellman, Luca Cegolon, M Miles, MG MacDonald, MJ Maisels, OM Campbell, Oona M. R. Campbell, P Braveman, S Brown, S Brown, S Brown, S Liu, U Waldenstrom   +33 more
core   +5 more sources