Results 71 to 80 of about 166,445,287 (303)
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Hospital-acquired, laboratory-confirmed bloodstream infection: increased hospital stay and direct costs. [PDF]
, 2002 OBJECTIVES: To determine increased hospital stay and direct costs attributable to hospital-acquired, laboratory-confirmed bloodstream infection (BSI), and to evaluate the matching variable length of stay (LOS).
NOAH N. +4 more
core +1 more source
The length of stay in tourism [PDF]
Annals of Tourism Research, 2010 Abstract Economic theory generally treats the duration of a vacation as a constraint on demand imposed by available time. In contrast, in this paper, it is shown that the length of stay is a determinant of destination demand rather than a demand characteristic.
Carlos Pestana Barros +1 more
openaire +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Emergency department crowding in the modern era: a systematic review (2018–2025) [PDF]
Clinical and Experimental Emergency MedicineObjective This study systematically reviews the causes, effects, and potential solutions to emergency department (ED) crowding, with emphasis on challenges amplified by the COVID-19 pandemic.
Jonathan J. Oskvarek +4 more
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Length-of-stay differentiated by mental comorbidity spectrum.
, 2023 μ: mean length-of-stay, plotted as diamonds; ci: 95% confidence interval; N: number of cases that have a diagnosis in the respective F-category (ICD-10 range starting with the characters F0-F6).
Christoph Nikendei (90906) +12 more
core +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Length-of-stay by age group and presence of mental comorbidity.
, 2023 These are the underlying numbers for Fig 3. N: number of cases; LOS: length-of-stay; CI95: 95% confidence interval. (DOCX)
Christoph Nikendei (90906) +12 more
core +1 more source
Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source